DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2717:2721

E3 ligase: SPOP

DEGRON score: 0.7959

ASA_SCORE: 92.58

COIL: 0.8934

CONS_SCORE: 0.5236

DSS_SCORE: 0.5925

HELIX: 0.0112

FCONS_SCORE: 1

RIG_SCORE: 0.6944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2718E	TCGA-B5-A11O	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.5647
p.D2718E	DO41650	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.5647
p.S2720C	DO27484	LUSC	ICGC	VDTST	DEG_SPOP_SBC_1	0.7541
p.A2727T	DO228349	MALY	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.A2727T	SK-UT-1	soft_tissue	COSMIC	VDTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04264	Keratin, type II cytoskeletal 1	DEG_SPOP_SBC_1	218:222	VDTST	SPOP	0.7287	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	536:540	VDTST	SPOP	0.8736	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	713:717	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	949:953	VDTST	SPOP	0.867	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1421:1425	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2717:2721	VDTST	SPOP	0.7959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2835:2839	VDTST	SPOP	0.8986	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	836:840	VDTST	SPOP	0.9896	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	424:428	VDTST	SPOP	0.9474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons