DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1421:1425

E3 ligase: SPOP

DEGRON score: 0.7955

ASA_SCORE: 92.38

COIL: 0.9204

CONS_SCORE: 0.5236

DSS_SCORE: 0.6462

HELIX: 0.0102

FCONS_SCORE: 1

RIG_SCORE: 0.6576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1421F	TCGA-55-8616	LUAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.7068
p.V1421F	DO23566	LUAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.7068
p.A1431D	TCGA-62-A46O	LUAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.1667
p.A1431D	DO26240	LUAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.S1414T	TCGA-95-7043	LUAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.1389
p.S1414T	DO24739	LUAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.A1433T	TCGA-AP-A059	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.1111
p.A1433T	DO41361	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111
p.E1432K	DO220875	MELA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.A1431T	SIDM00884	Breast Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04264	Keratin, type II cytoskeletal 1	DEG_SPOP_SBC_1	218:222	VDTST	SPOP	0.7287	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	536:540	VDTST	SPOP	0.8736	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	713:717	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	949:953	VDTST	SPOP	0.867	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1421:1425	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2717:2721	VDTST	SPOP	0.7959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2835:2839	VDTST	SPOP	0.8986	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	836:840	VDTST	SPOP	0.9896	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	424:428	VDTST	SPOP	0.9474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons