DegronMD

Uniprot ID: Q9P1A6

Source protein: Disks large-associated protein 2

Source gene: DLGAP2

Class: DEG_SPOP_SBC_1

Location: 836:840

E3 ligase: SPOP

DEGRON score: 0.9896

ASA_SCORE: 87.46

COIL: 0.9236

CONS_SCORE: 0.4116

DSS_SCORE: 0.5842

HELIX: 0.0484

FCONS_SCORE: 0.9569

RIG_SCORE: 0.7288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V830I	TCGA-AB-2806	LAML	TCGA	VDTST	DEG_SPOP_SBC_1	0.1667
p.V830I	DO21283	LAML	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.M837V	TCGA-D1-A17D	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.7208
p.M837V	DO41746	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.7208
p.F844L	TCGA-D1-A17Q	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.2222
p.F844L	DO41903	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.2222
p.W846C	TCGA-DX-AB2Q	SARC	TCGA	VDTST	DEG_SPOP_SBC_1	0.1667
p.W846C	DO220087	SARC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.Q834K	TCGA-ER-A19P	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	0.2778
p.Q834K	DO47623	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	0.2778
p.Y845H	DO233621	GACA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1944
p.Q839H	DO221540	PACA	ICGC	VDTST	DEG_SPOP_SBC_1	0.7582
p.F844C	DO36556	READ	ICGC	VDTST	DEG_SPOP_SBC_1	0.2222
p.R834W	SIDM00974	Melanoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2778
p.R834W	WM35	skin	COSMIC	VDTST	DEG_SPOP_SBC_1	0.2778
p.F827L	SIDM01187	Breast Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.5278
p.F827L	UACC-812	breast	COSMIC	VDTST	DEG_SPOP_SBC_1	0.5278
p.C848S	ACH-001991	Primary	CCLE	VDTST	DEG_SPOP_SBC_1	0.1111
p.T841A	NCI-H630	large_intestine	COSMIC	VDTST	DEG_SPOP_SBC_1	0.3056
p.F826L	UACC-812	breast	COSMIC	VDTST	DEG_SPOP_SBC_1	0.0556
p.T840A	NCI-H630	large_intestine	COSMIC	VDTST	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04264	Keratin, type II cytoskeletal 1	DEG_SPOP_SBC_1	218:222	VDTST	SPOP	0.7287	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	536:540	VDTST	SPOP	0.8736	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	713:717	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	949:953	VDTST	SPOP	0.867	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1421:1425	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2717:2721	VDTST	SPOP	0.7959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2835:2839	VDTST	SPOP	0.8986	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	836:840	VDTST	SPOP	0.9896	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	424:428	VDTST	SPOP	0.9474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons