DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 949:953

E3 ligase: SPOP

DEGRON score: 0.867

ASA_SCORE: 94.7

COIL: 0.8884

CONS_SCORE: 0.5236

DSS_SCORE: 0.6551

HELIX: 0.0104

FCONS_SCORE: 1

RIG_SCORE: 0.6747

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A961V	TCGA-09-2051	OV	TCGA	VDTST	DEG_SPOP_SBC_1	0.1111
p.A961V	DO31450	OV	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111
p.R942T	TCGA-49-4494	LUAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.1389
p.R942T	TCGA-NK-A7XE	LUSC	TCGA	VDTST	DEG_SPOP_SBC_1	0.1389
p.R942T	DO24245	LUAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.R942T	DO219215	LUSC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.T951N	TCGA-70-6722	LUSC	TCGA	VDTST	DEG_SPOP_SBC_1	0.7055
p.T951N	DO27755	LUSC	ICGC	VDTST	DEG_SPOP_SBC_1	0.7055
p.T951N	SIDM00232	Kidney Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.7055
p.T951N	ACH-002168	Kidney Cancer	CCLE	VDTST	DEG_SPOP_SBC_1	0.7055
p.T951N	NCC021	kidney	COSMIC	VDTST	DEG_SPOP_SBC_1	0.7055
p.A961T	TCGA-A5-A0G2	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.1111
p.A961T	DO41235	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111
p.S952G	TCGA-BR-4370	STAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.6993
p.S952G	DO38499	STAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.6993
p.E940Q	TCGA-C8-A12T	BRCA	TCGA	VDTST	DEG_SPOP_SBC_1	0.0833
p.E940Q	DO5507	BRCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.E940V	DO227976	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.T959A	DO222755	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.T959A	DO222869	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.T959A	DO229013	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.T959A	DO229016	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.T959A	DO52365	LUSC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.T959A	DO52357	LUSC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.A941V	DO222849	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111
p.A941V	DO229013	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111
p.A941V	DO229016	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111
p.R942S	DO229013	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.R942S	DO229016	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.R942S	DO52365	LUSC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.E940G	DO229013	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.E940G	DO229016	COCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.T962S	DO228943	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.T962S	DO228948	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.T962S	DO229030	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.T962S	DO229053	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.V949I	DO229462	SKCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.7076
p.D950N	SIDM00477	Esophageal Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.5821
p.D950N	ACH-000383	Esophageal Cancer	CCLE	VDTST	DEG_SPOP_SBC_1	0.5821
p.D950N	OE33	oesophagus	COSMIC	VDTST	DEG_SPOP_SBC_1	0.5821
p.A941D	SIDM00148	Breast Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.1111
p.A941D	MCF7	breast	COSMIC	VDTST	DEG_SPOP_SBC_1	0.1111
p.T943K	ACH-001321	Thyroid Cancer	CCLE	VDTST	DEG_SPOP_SBC_1	0.6111
p.T943K	TT	thyroid	COSMIC	VDTST	DEG_SPOP_SBC_1	0.6111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VDTST

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of VDTST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04264	Keratin, type II cytoskeletal 1	DEG_SPOP_SBC_1	218:222	VDTST	SPOP	0.7287	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	536:540	VDTST	SPOP	0.8736	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	713:717	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	949:953	VDTST	SPOP	0.867	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1421:1425	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2717:2721	VDTST	SPOP	0.7959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2835:2839	VDTST	SPOP	0.8986	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	836:840	VDTST	SPOP	0.9896	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	424:428	VDTST	SPOP	0.9474	More...