DegronMD

Uniprot ID: Q92576

Source protein: PHD finger protein 3

Source gene: PHF3

Class: DEG_SPOP_SBC_1

Location: 424:428

E3 ligase: SPOP

DEGRON score: 0.9474

ASA_SCORE: 80.32

COIL: 0.7764

CONS_SCORE: 0.3067

DSS_SCORE: 0.4417

HELIX: 0.1526

FCONS_SCORE: 0.9426

RIG_SCORE: 0.763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T428S	TCGA-44-A4SS	LUAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.6005
p.T428S	DO24227	LUAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.6005
p.K418E	TCGA-A6-6142	COAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.2778
p.K418E	DO9988	COAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.2778
p.I435T	TCGA-AA-A010	COAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.1389
p.I435V	TCGA-BA-A6DD	HNSC	TCGA	VDTST	DEG_SPOP_SBC_1	0.1389
p.I435V	DO44452	HNSC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.S419L	TCGA-D3-A2J6	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	0.1944
p.S419L	DO37901	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	0.1944
p.L421F	DO49140	PACA	ICGC	VDTST	DEG_SPOP_SBC_1	0.25
p.E432K	SIDM00672	Hepatocellular Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E432K	SIDM01117	Small Cell Lung Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E432K	SIDM00878	Breast Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E432K	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E432K	SIDM00844	Burkitt's Lymphoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E432K	SIDM00863	Burkitt's Lymphoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E432K	SIDM00628	Breast Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E432K	SIDM01318	Hepatocellular Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E432K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E432K	SIDM01752	Pancreatic Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.2222
p.S427R	SIDM00340	Plasma Cell Myeloma	GDSC	VDTST	DEG_SPOP_SBC_1	0.7427
p.S427R	ACH-000204	Myeloma	CCLE	VDTST	DEG_SPOP_SBC_1	0.7427
p.S427R	LP-1	haematopoietic_and_lymphoid_tissue	COSMIC	VDTST	DEG_SPOP_SBC_1	0.7427
p.D425H	ACH-000836	Head and Neck Cancer	CCLE	VDTST	DEG_SPOP_SBC_1	0.6577

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04264	Keratin, type II cytoskeletal 1	DEG_SPOP_SBC_1	218:222	VDTST	SPOP	0.7287	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	536:540	VDTST	SPOP	0.8736	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	713:717	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	949:953	VDTST	SPOP	0.867	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1421:1425	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2717:2721	VDTST	SPOP	0.7959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2835:2839	VDTST	SPOP	0.8986	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	836:840	VDTST	SPOP	0.9896	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	424:428	VDTST	SPOP	0.9474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VDTST

Degron related mutations and impact score

Drug responses associated with PHF3 mutations

All proteins holding degron of VDTST