DegronMD - Q9Y6N7(ROBO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1062H	TCGA-13-1491	OV	TCGA	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1111
p.R1062H	TCGA-HW-8322	LGG	TCGA	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1111
p.G1103R	TCGA-18-5595	LUSC	TCGA	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1389
p.S1609T	TCGA-23-1116	OV	TCGA	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.2222
p.G1068R	TCGA-24-1426	OV	TCGA	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.2778
p.S1605N	TCGA-50-6595	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation altering degron motif	0.7069
p.P1101S	TCGA-5M-AAT6	COAD	TCGA	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1944
p.A1074S	TCGA-86-7713	LUAD	TCGA	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation altering degron motif	0.6477
p.P1598S	TCGA-90-A4ED	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.25
p.L1122M	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.25
p.R1062C	TCGA-A5-A0G2	UCEC	TCGA	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1111
p.R1062C	TCGA-AX-A3FT	UCEC	TCGA	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1111
p.A972V	TCGA-AA-3837	COAD	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.A972V	TCGA-VR-AA4D	ESCA	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.A972V	SIDM00817	Kidney Carcinoma	GDSC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.A972V	ACH-002191	Kidney Cancer	CCLE	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.A972V	RCC-JW	kidney	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.S1608P	TCGA-AJ-A3EL	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.25
p.R961M	TCGA-AP-A1DH	UCEC	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.8632
p.T1367M	TCGA-AX-A0J1	UCEC	TCGA	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0833
p.T1367M	TCGA-F5-6861	READ	TCGA	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0833
p.D1361G	TCGA-AX-A1CE	UCEC	TCGA	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.25
p.R1349C	TCGA-B5-A3FC	UCEC	TCGA	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.2778
p.R1349C	TCGA-EO-A3AZ	UCEC	TCGA	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.2778
p.E954K	TCGA-BG-A18B	UCEC	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1667
p.N1120S	TCGA-BG-A222	UCEC	TCGA	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.1944
p.Q1105R	TCGA-BR-A4QM	STAD	TCGA	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.0833
p.A972T	TCGA-C8-A8HR	BRCA	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.A972T	SIDM01942	Colorectal Carcinoma	GDSC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.Q1105H	TCGA-CC-A7IH	LIHC	TCGA	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.0833
p.D1600N	TCGA-D3-A5GO	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.3056
p.G952E	TCGA-D8-A1JA	BRCA	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1111
p.N1596S	TCGA-DI-A1BU	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.1944
p.R1615T	TCGA-DK-A3WW	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.0556
p.A1074V	TCGA-DM-A28F	COAD	TCGA	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation altering degron motif	0.5825
p.G960E	TCGA-EB-A3XB	SKCM	TCGA	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.6087
p.G1068W	TCGA-EE-A2GN	SKCM	TCGA	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.2778
p.P1133L	TCGA-EE-A3JA	SKCM	TCGA	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.1667
p.E1352K	TCGA-ER-A199	SKCM	TCGA	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation altering degron motif	0.591
p.S1357Y	TCGA-F2-A8YN	PAAD	TCGA	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation altering degron motif	0.6009
p.D1600Y	TCGA-F5-6814	READ	TCGA	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.3056
p.D1600Y	SIDM00534	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.3056
p.D1600Y	ACH-000986	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.3056
p.D1600Y	HT-115	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.3056
p.V1064G	TCGA-FD-A6TG	BLCA	TCGA	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1667
p.E1367Q	DO49795	BLCA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0833
p.G1341E	DO468	BLCA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0556
p.V1129A	DO222986	BTCA	ICGC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.2778
p.D1347H	DO51612	CESC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.2222
p.S1343C	DO49939	CESC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.1111
p.R1342C	DO8119	COAD	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0833
p.R1342C	DO10076	COAD	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0833
p.R1342C	DO227996	COCA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0833
p.G1341R	DO7950	COAD	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0556
p.G1341R	DO52652	MALY	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0556
p.S1119G	DO8224	COAD	ICGC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.1667
p.A1083T	DO230343	COCA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1111
p.A1083T	DO230343	COCA	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1111
p.P967Q	DO50341	ESAD	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.7035
p.G1064E	DO234191	ESAD	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1667
p.K1137R	DO234363	ESAD	ICGC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.0556
p.N956I	DO234377	ESAD	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.K1127R	DO233096	GACA	ICGC	DYR	CBL_MET	1125:1127	Mutation altering degron motif	0.7237
p.K1127R	DO233901	GACA	ICGC	DYR	CBL_MET	1125:1127	Mutation altering degron motif	0.7237
p.Q977H	DO233239	GACA	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.0833
p.K1121M	DO233245	GACA	ICGC	DYR	CBL_MET	1125:1127	Mutation blocking ubiquitination signal	0.6667
p.K1121M	DO38591	STAD	ICGC	DYR	CBL_MET	1125:1127	Mutation blocking ubiquitination signal	0.6667
p.M1350T	DO233876	GACA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.3056
p.G1123V	DO14302	HNSC	ICGC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.2778
p.H1120N	DO49807	KIRP	ICGC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.1944
p.I971L	DO228487	LICA	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.25
p.Q1101K	DO229019	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1944
p.P1094T	DO229019	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation altering degron motif	0.7031
p.A1089E	DO229019	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.2778
p.A1089E	DO229034	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.2778
p.P1360T	DO229034	LICA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.2778
p.N1081K	DO229037	LICA	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.0556
p.N1081K	DO229037	LICA	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1667
p.S959R	DO229045	LICA	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.3056
p.A1361V	DO50976	LICA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.25
p.E1367D	DO44883	LIHC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0833
p.Q1060H	DO52181	LIHC	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.I971V	DO23290	LINC	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.25
p.D975G	DO23146	LINC	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1389
p.D975G	DO45071	LINC	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1389
p.S1104P	DO45139	LIRI	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1111
p.V1344L	DO23711	LUAD	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.1389
p.A1083S	DO231204	LUSC	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1111
p.A1083S	DO231204	LUSC	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1111
p.Y1093H	DO26587	LUSC	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation altering degron motif	0.7229
p.E1367V	DO26479	LUSC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.0833
p.G1064R	DO27373	LUSC	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1667
p.Q1074H	DO46366	OV	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation altering degron motif	0.7582
p.R1131I	DO46657	PAAD	ICGC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.2222
p.R966C	DO36394	READ	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.8301
p.R1116Q	DO218841	SKCA	ICGC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.0833
p.Q1124H	DO47407	SKCM	ICGC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.3056
p.P1088L	DO47625	SKCM	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.25
p.G1061W	DO38623	STAD	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0833
p.Q1060R	DO47871	STAD	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.A972S	DO47853	STAD	ICGC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.R1125G	DO47853	STAD	ICGC	DYR	CBL_MET	1125:1127	Mutation altering degron motif	0.7568
p.S1351P	DO42977	UCEC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation altering degron motif	0.6752
p.N1075S	DO42977	UCEC	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation altering degron motif	0.7069
p.G1061V	DO41999	UCEC	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0833
p.L1083M	DO41235	UCEC	ICGC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1111
p.L1083M	DO41235	UCEC	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1111
p.Q1063K	DO41373	UCEC	ICGC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1389
p.S1091I	SIDM00499	Prostate Carcinoma	GDSC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation altering degron motif	0.7341
p.S1091I	22RV1	prostate	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation altering degron motif	0.7341
p.N1085S	SIDM01175	Other Sarcomas	GDSC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1667
p.N1085S	SIDM01175	Other Sarcomas	GDSC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.N1085S	ACH-002309	Sarcoma	CCLE	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1667
p.N1085S	ACH-002309	Sarcoma	CCLE	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.N1085S	SW684	soft tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1667
p.N1085S	SW684	soft tissue	COSMIC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.S1602N	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation altering degron motif	0.5958
p.S1602N	SIDM00238	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation altering degron motif	0.5958
p.S1602N	SLVL	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation altering degron motif	0.5958
p.S1602N	OVK-18	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation altering degron motif	0.5958
p.R1610K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.1944
p.R1610K	ACH-002215	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.1944
p.R1610K	BC-3	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.1944
p.V956A	SIDM00537	Colorectal Carcinoma	GDSC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.V956A	ACH-000982	Colon/Colorectal Cancer	CCLE	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.V956A	ACH-001345	Colon/Colorectal Cancer	CCLE	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.V956A	GP5d	large intestine	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2222
p.D1060V	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.D1060V	NCI-H1703	lung	COSMIC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.D1060Y	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.D1060Y	ACH-000747	Lung Cancer	CCLE	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.D1060Y	NCI-H1703	lung	COSMIC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.Q973R	SIDM00534	Colorectal Carcinoma	GDSC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1944
p.Q973R	ACH-000986	Colon/Colorectal Cancer	CCLE	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1944
p.Q973R	HT-115	large intestine	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1944
p.L1346F	SIDM01254	Burkitt's Lymphoma	GDSC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.1944
p.L1346F	ACH-000707	Lymphoma	CCLE	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.1944
p.T1594I	ACH-000170	Non-Cancerous	CCLE	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.1389
p.T1591S	ACH-000617	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation rewiring degron network	0.0556
p.D1060F	ACH-000747	Lung Cancer	CCLE	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.0556
p.P1070S	ACH-000941	Endometrial/Uterine Cancer	CCLE	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation altering degron motif	0.6752
p.S1603F	ACH-001523	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1601:1605	Mutation altering degron motif	0.9093
p.L1083P	ACH-002256	Leukemia	CCLE	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1111
p.L1083P	ACH-002256	Leukemia	CCLE	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1111
p.L1083P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1111
p.L1083P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1111
p.D958N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.2778
p.V1064M	RL95-2	endometrium	COSMIC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1667
p.V1098M	PSN1	pancreas	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.2778
p.V1098M	OVKATE	ovary	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.2778
p.G1118D	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.1389
p.V1092M	PSN1	pancreas	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation altering degron motif	0.7208
p.V1092M	OVKATE	ovary	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation altering degron motif	0.7208
p.N965S	SW684	soft tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.7069
p.S965I	22RV1	prostate	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.7341
p.L963P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.7582
p.V1118M	PSN1	pancreas	COSMIC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.1389
p.V1118M	OVKATE	ovary	COSMIC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.1389
p.R1346C	CCK-81	large intestine	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.1944
p.R1352C	CCK-81	large intestine	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation altering degron motif	0.8301
p.E1348Q	NCI-H2126	lung	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.25
p.N1094K	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation altering degron motif	0.6918
p.N959S	SW684	soft tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.3056
p.T1346A	MZ7-mel	skin	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.1944
p.L957P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.25
p.S971I	22RV1	prostate	COSMIC	GRPGLLNIS	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.25
p.Y1102C	MN-60	haematopoietic and lymphoid tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.1667
p.P1130L	MCC13	skin	COSMIC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.25
p.P1124L	MCC13	skin	COSMIC	DYR	CBL_MET	1125:1127	Mutation rewiring degron network	0.3056
p.L1360I	NCI-H28	pleura	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation rewiring degron network	0.2778
p.Y1082C	MN-60	haematopoietic and lymphoid tissue	COSMIC	SGDSGE	DEG_Kelch_Keap1_1	1091:1096	Mutation rewiring degron network	0.0833
p.Y1082C	MN-60	haematopoietic and lymphoid tissue	COSMIC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.1389
p.Y1076C	MN-60	haematopoietic and lymphoid tissue	COSMIC	PTPYAT	DEG_SCF_FBW7_1	1070:1075	Mutation rewiring degron network	0.3056
p.L1354I	NCI-H28	pleura	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation altering degron motif	0.7174
p.E1354Q	NCI-H2126	lung	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	1351:1358	Mutation altering degron motif	0.6744

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ROBO1

UniProt ID: Q9Y6N7

Entrez ID: 6091

Protein name: Roundabout homolog 1 (Deleted in U twenty twenty) (H-Robo-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ROBO1 in