DegronMD

Uniprot ID: Q9Y6N7

Source protein: Roundabout homolog 1

Source gene: ROBO1

Class: DEG_SCF_FBW7_1

Location: 1351:1358

E3 ligase: FBXW7

DEGRON score: 0.9396

ASA_SCORE: 75.65

COIL: 0.8396

CONS_SCORE: 0.4734

DSS_SCORE: 0.4908

HELIX: 0.1056

FCONS_SCORE: 1.459

RIG_SCORE: 0.6984

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1367M	TCGA-AX-A0J1	UCEC	TCGA	LEQTPASS	DEG_SCF_FBW7_1	0.0833
p.T1367M	TCGA-F5-6861	READ	TCGA	LEQTPASS	DEG_SCF_FBW7_1	0.0833
p.D1361G	TCGA-AX-A1CE	UCEC	TCGA	LEQTPASS	DEG_SCF_FBW7_1	0.25
p.R1349C	TCGA-B5-A3FC	UCEC	TCGA	LEQTPASS	DEG_SCF_FBW7_1	0.2778
p.R1349C	TCGA-EO-A3AZ	UCEC	TCGA	LEQTPASS	DEG_SCF_FBW7_1	0.2778
p.E1352K	TCGA-ER-A199	SKCM	TCGA	LEQTPASS	DEG_SCF_FBW7_1	0.591
p.S1357Y	TCGA-F2-A8YN	PAAD	TCGA	LEQTPASS	DEG_SCF_FBW7_1	0.6009
p.E1367Q	DO49795	BLCA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.0833
p.G1341E	DO468	BLCA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.0556
p.D1347H	DO51612	CESC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.2222
p.S1343C	DO49939	CESC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.1111
p.R1342C	DO8119	COAD	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.0833
p.R1342C	DO10076	COAD	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.0833
p.R1342C	DO227996	COCA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.0833
p.G1341R	DO7950	COAD	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.0556
p.G1341R	DO52652	MALY	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.0556
p.M1350T	DO233876	GACA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.3056
p.P1360T	DO229034	LICA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.2778
p.A1361V	DO50976	LICA	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.25
p.E1367D	DO44883	LIHC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.0833
p.V1344L	DO23711	LUAD	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.1389
p.E1367V	DO26479	LUSC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.0833
p.S1351P	DO42977	UCEC	ICGC	LEQTPASS	DEG_SCF_FBW7_1	0.6752
p.L1346F	SIDM01254	Burkitt's Lymphoma	GDSC	LEQTPASS	DEG_SCF_FBW7_1	0.1944
p.L1346F	ACH-000707	Lymphoma	CCLE	LEQTPASS	DEG_SCF_FBW7_1	0.1944
p.R1346C	CCK-81	large_intestine	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	0.1944
p.R1352C	CCK-81	large_intestine	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	0.8301
p.E1348Q	NCI-H2126	lung	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	0.25
p.T1346A	MZ7-mel	skin	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	0.1944
p.L1360I	NCI-H28	pleura	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	0.2778
p.L1354I	NCI-H28	pleura	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	0.7174
p.E1354Q	NCI-H2126	lung	COSMIC	LEQTPASS	DEG_SCF_FBW7_1	0.6744

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LEQTPASS

Degron related mutations and impact score

Drug responses associated with ROBO1 mutations

All proteins holding degron of LEQTPASS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6N7	Roundabout homolog 1	DEG_SCF_FBW7_1	1351:1358	LEQTPASS	FBXW7	0.9396	More...