DegronMD

Uniprot ID: Q9Y6N7

Source protein: Roundabout homolog 1

Source gene: ROBO1

Class: DEG_SPOP_SBC_1

Location: 1601:1605

E3 ligase: SPOP

DEGRON score: 0.9801

ASA_SCORE: 78.28

COIL: 0.8854

CONS_SCORE: 0.2725

DSS_SCORE: 0.7897

HELIX: 0.0962

FCONS_SCORE: 1.0083

RIG_SCORE: 0.5191

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1603F	ACH-001523	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.9093
p.S1605N	TCGA-50-6595	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	0.7069
p.S1602N	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.5958
p.S1602N	SIDM00238	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.5958
p.S1602N	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.5958
p.S1602N	OVK-18	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.5958
p.D1600N	TCGA-D3-A5GO	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	0.3056
p.D1600Y	TCGA-F5-6814	READ	TCGA	PSSSS	DEG_SPOP_SBC_1	0.3056
p.D1600Y	SIDM00534	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.3056
p.D1600Y	ACH-000986	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.3056
p.D1600Y	HT-115	large_intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.3056
p.P1598S	TCGA-90-A4ED	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	0.25
p.S1608P	TCGA-AJ-A3EL	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	0.25
p.S1609T	TCGA-23-1116	OV	TCGA	PSSSS	DEG_SPOP_SBC_1	0.2222
p.N1596S	TCGA-DI-A1BU	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	0.1944
p.R1610K	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.1944
p.R1610K	ACH-002215	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	0.1944
p.R1610K	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.1944
p.T1594I	ACH-000170	Non-Cancerous	CCLE	PSSSS	DEG_SPOP_SBC_1	0.1389
p.R1615T	TCGA-DK-A3WW	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	0.0556
p.T1591S	ACH-000617	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 21 of 21 entries

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Drug responses associated with ROBO1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PSSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1276:1280	PSSSS	SPOP	0.9293	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	698:702	PSSSS	SPOP	0.9524	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	832:836	PSSSS	SPOP	0.995	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1144:1148	PSSSS	SPOP	0.9971	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1872:1876	PSSSS	SPOP	0.9707	More...
Q9Y4X0	AMME syndrome candidate gene 1 protein	DEG_SPOP_SBC_1	108:112	PSSSS	SPOP	0.7876	More...
P48751	Anion exchange protein 3	DEG_SPOP_SBC_1	441:445	PSSSS	SPOP	0.9863	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	2295:2299	PSSSS	SPOP	0.9846	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	863:867	PSSSS	SPOP	0.9942	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_SPOP_SBC_1	1242:1246	PSSSS	SPOP	0.9873	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1281:1285	PSSSS	SPOP	0.6698	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	214:218	PSSSS	SPOP	0.7612	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	841:845	PSSSS	SPOP	0.9975	More...
Q16585	Beta-sarcoglycan	DEG_SPOP_SBC_1	269:273	PSSSS	SPOP	0.5268	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	290:294	PSSSS	SPOP	0.9979	More...
Q9UDT6	CAP-Gly domain-containing linker protein 2	DEG_SPOP_SBC_1	315:319	PSSSS	SPOP	0.9467	More...
O75052	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	DEG_SPOP_SBC_1	272:276	PSSSS	SPOP	0.9973	More...
Q9NQ75	Cas scaffolding protein family member 4	DEG_SPOP_SBC_1	273:277	PSSSS	SPOP	0.999	More...
Q9H3Q1	Cdc42 effector protein 4	DEG_SPOP_SBC_1	69:73	PSSSS	SPOP	0.9451	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	531:535	PSSSS	SPOP	0.864	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2080:2084	PSSSS	SPOP	0.9952	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	151:155	PSSSS	SPOP	0.9715	More...
P38432	Coilin	DEG_SPOP_SBC_1	244:248	PSSSS	SPOP	0.9884	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	358:362	PSSSS	SPOP	0.8546	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	301:305	PSSSS	SPOP	0.6405	More...

Showing 1 to 25 of 159 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSSS

Degron related mutations and impact score

Drug responses associated with ROBO1 mutations

All proteins holding degron of PSSSS