DegronMD - P22607(FGFR3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S781R	TCGA-53-7813	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.7427
p.S781R	DO24349	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.7427
p.D788N	TCGA-CV-5442	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1667
p.D788N	DO14678	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1667
p.S789F	TCGA-EE-A2A2	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1389
p.S789F	DO220852	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1389
p.S789F	DO37583	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1389
p.F769L	DO222431	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0833
p.V784M	DO10443	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2778
p.T779N	DO233892	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.7055
p.G774S	DO37782	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.2222
p.A792V	DO229084	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556
p.S773F	SIDM01160	Bladder Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.1944
p.P780H	SIDM00498	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.7694
p.P780H	SNU-C5	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.7694
p.S771F	ACH-000384	Bladder Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation blocking phosphorylation signal	0.5833
p.P778H	ACH-000970	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.7694
p.P778H	SNU-C5	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation altering degron motif	0.7694
p.P768T	ACH-001061	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	778:782	Mutation rewiring degron network	0.0556

Kaplan plot for FGFR3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FGFR3

UniProt ID: P22607

Entrez ID: 2261

Protein name: Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FGFR3 in