DegronMD

Uniprot ID: P22607

Source protein: Fibroblast growth factor receptor 3

Source gene: FGFR3

Class: DEG_SPOP_SBC_1

Location: 778:782

E3 ligase: SPOP

DEGRON score: 0.9964

ASA_SCORE: 85.36

COIL: 0.9574

CONS_SCORE: 0.4495

DSS_SCORE: 0.7664

HELIX: 0.0246

FCONS_SCORE: 1.1197

RIG_SCORE: 0.5088

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S781R	TCGA-53-7813	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	0.7427
p.S781R	DO24349	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	0.7427
p.D788N	TCGA-CV-5442	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	0.1667
p.D788N	DO14678	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1667
p.S789F	TCGA-EE-A2A2	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	0.1389
p.S789F	DO220852	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1389
p.S789F	DO37583	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1389
p.F769L	DO222431	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.0833
p.V784M	DO10443	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	0.2778
p.T779N	DO233892	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.7055
p.G774S	DO37782	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	0.2222
p.A792V	DO229084	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.0556
p.S773F	SIDM01160	Bladder Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.1944
p.P780H	SIDM00498	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.7694
p.P780H	SNU-C5	large_intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.7694
p.S771F	ACH-000384	Bladder Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.5833
p.P778H	ACH-000970	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.7694
p.P778H	SNU-C5	large_intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.7694
p.P768T	ACH-001061	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.0556

Drug responses associated with FGFR3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.T79S (No)	GDSC	PD173074	45.0999
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.T79S (No)	GDSC	AZD4547	77.292
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.T79S (No)	GDSC	FGFR_3831	147.043
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.T79S (No)	GDSC	AZD4547	13.514
SIDM00240	CESC\|cervix	p.P763S (No)	GDSC	PD173074	32.0519
SIDM00240	CESC\|cervix	p.P763S (No)	GDSC	AZD4547	21.0992
SIDM00240	CESC\|cervix	p.P763S (No)	GDSC	FGFR_3831	30.6595
SIDM00240	CESC\|cervix	p.P763S (No)	GDSC	AZD4547	13.9722
SIDM00309	MESO\|mesothelioma	p.A717T (No)	GDSC	AZD4547	4.9622
SIDM00309	MESO\|mesothelioma	p.A717T (No)	GDSC	FGFR_3831	21.8102
SIDM01024	ESCA\|oesophagus	p.N718S (No)	GDSC	PD173074	7.2957
SIDM01024	ESCA\|oesophagus	p.N718S (No)	GDSC	AZD4547	28.4351
SIDM01024	ESCA\|oesophagus	p.N718S (No)	GDSC	FGFR_3831	43.5641
SIDM01024	ESCA\|oesophagus	p.N718S (No)	GDSC	AZD4547	19.0856
SIDM01024	ESCA\|oesophagus	p.N718S (No)	GDSC	PD173074	298.69
SIDM01024	ESCA\|oesophagus	p.N718S (No)	GDSC	AZD4547	131.68
SIDM00498	COREAD\|large_intestine	p.K403fs*93 (No)	GDSC	PD173074	37.3246
SIDM00498	COREAD\|large_intestine	p.K403fs*93 (No)	GDSC	AZD4547	99.762
SIDM00498	COREAD\|large_intestine	p.K403fs*93 (No)	GDSC	FGFR_3831	59.5653
SIDM00498	COREAD\|large_intestine	p.K403fs*93 (No)	GDSC	AZD4547	16.0237
SIDM00498	COREAD\|large_intestine	p.K403fs*93 (No)	GDSC	PD173074	44.671
SIDM00498	COREAD\|large_intestine	p.K403fs*93 (No)	GDSC	AZD4547	76.354
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.A558V (No)	GDSC	PD173074	8.2667
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.A558V (No)	GDSC	AZD4547	8.4327
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.A558V (No)	GDSC	FGFR_3831	4.7567
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.A558V (No)	GDSC	AZD4547	4.0624
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.A558V (No)	GDSC	PD173074	14.186
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.A558V (No)	GDSC	AZD4547	1.8498
SIDM00970	BLCA\|bladder	p.G65R (No)	GDSC	PD173074	14.868
SIDM00970	BLCA\|bladder	p.G65R (No)	GDSC	AZD4547	5.6416
SIDM00970	BLCA\|bladder	p.G65R (No)	GDSC	FGFR_3831	45.8738
SIDM00970	BLCA\|bladder	p.G65R (No)	GDSC	AZD4547	8.5458
SIDM00970	BLCA\|bladder	p.G65R (No)	GDSC	PD173074	43.719
SIDM00970	BLCA\|bladder	p.G65R (No)	GDSC	AZD4547	27.671
SIDM00315	GBM\|glioma	p.G44S (No)	GDSC	PD173074	8.2904
SIDM00315	GBM\|glioma	p.G44S (No)	GDSC	AZD4547	26.1634
SIDM00315	GBM\|glioma	p.G44S (No)	GDSC	FGFR_3831	8.0344
SIDM00315	GBM\|glioma	p.G44S (No)	GDSC	AZD4547	9.1608
SIDM01045	UCEC\|endometrium	p.K403fs*30 (No)	GDSC	PD173074	44.3252
SIDM01045	UCEC\|endometrium	p.K403fs*30 (No)	GDSC	AZD4547	42.1888
SIDM01045	UCEC\|endometrium	p.K403fs*30 (No)	GDSC	FGFR_3831	22.6992
SIDM01045	UCEC\|endometrium	p.K403fs*30 (No)	GDSC	AZD4547	21.9324
SIDM01045	UCEC\|endometrium	p.K403fs*30 (No)	GDSC	PD173074	162.85
SIDM01045	UCEC\|endometrium	p.K403fs*30 (No)	GDSC	AZD4547	89.598
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.V411M (No)	GDSC	PD173074	13.7665
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.V411M (No)	GDSC	AZD4547	9.3977
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.V411M (No)	GDSC	FGFR_3831	6.0668
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.V411M (No)	GDSC	AZD4547	6.3054
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.V411M (No)	GDSC	PD173074	25.513
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.V411M (No)	GDSC	AZD4547	1.3619
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	PD173074	5.3529
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	AZD4547	5.9409
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	FGFR_3831	1.2012
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	AZD4547	1.9435
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	PD173074	36.262
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	AZD4547	24.727
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	PD173074	5.3529
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	AZD4547	5.9409
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	FGFR_3831	1.2012
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	AZD4547	1.9435
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	PD173074	36.262
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	AZD4547	24.727
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	PD173074	5.3529
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	AZD4547	5.9409
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	FGFR_3831	1.2012
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	AZD4547	1.9435
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	PD173074	36.262
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	AZD4547	24.727
SIDM00145	ALL\|lymphoblastic_leukemia	p.R712H (No)	GDSC	PD173074	5.3529
SIDM00145	ALL\|lymphoblastic_leukemia	p.R712H (No)	GDSC	AZD4547	5.9409
SIDM00145	ALL\|lymphoblastic_leukemia	p.R712H (No)	GDSC	FGFR_3831	1.2012
SIDM00145	ALL\|lymphoblastic_leukemia	p.R712H (No)	GDSC	AZD4547	1.9435
SIDM00145	ALL\|lymphoblastic_leukemia	p.R712H (No)	GDSC	PD173074	36.262
SIDM00145	ALL\|lymphoblastic_leukemia	p.R712H (No)	GDSC	AZD4547	24.727
SIDM00145	ALL\|lymphoblastic_leukemia	p.M713I (No)	GDSC	PD173074	5.3529
SIDM00145	ALL\|lymphoblastic_leukemia	p.M713I (No)	GDSC	AZD4547	5.9409
SIDM00145	ALL\|lymphoblastic_leukemia	p.M713I (No)	GDSC	FGFR_3831	1.2012
SIDM00145	ALL\|lymphoblastic_leukemia	p.M713I (No)	GDSC	AZD4547	1.9435
SIDM00145	ALL\|lymphoblastic_leukemia	p.M713I (No)	GDSC	PD173074	36.262
SIDM00145	ALL\|lymphoblastic_leukemia	p.M713I (No)	GDSC	AZD4547	24.727
SIDM00145	ALL\|lymphoblastic_leukemia	p.A717T (No)	GDSC	PD173074	5.3529
SIDM00145	ALL\|lymphoblastic_leukemia	p.A717T (No)	GDSC	AZD4547	5.9409
SIDM00145	ALL\|lymphoblastic_leukemia	p.A717T (No)	GDSC	FGFR_3831	1.2012
SIDM00145	ALL\|lymphoblastic_leukemia	p.A717T (No)	GDSC	AZD4547	1.9435
SIDM00145	ALL\|lymphoblastic_leukemia	p.A717T (No)	GDSC	PD173074	36.262
SIDM00145	ALL\|lymphoblastic_leukemia	p.A717T (No)	GDSC	AZD4547	24.727
SIDM01139	PAAD\|pancreas	p.R151W (No)	GDSC	PD173074	14.6327
SIDM01139	PAAD\|pancreas	p.R151W (No)	GDSC	FGFR_3831	62.2144
SIDM01139	PAAD\|pancreas	p.R151W (No)	GDSC	AZD4547	12.6924
SIDM01139	PAAD\|pancreas	p.R151W (No)	GDSC	PD173074	213.73
SIDM01139	PAAD\|pancreas	p.R151W (No)	GDSC	AZD4547	67.248
SIDM00121	ALL\|lymphoblastic_leukemia	p.R359* (No)	GDSC	PD173074	2.6702
SIDM00121	ALL\|lymphoblastic_leukemia	p.R359* (No)	GDSC	AZD4547	3.6579
SIDM00121	ALL\|lymphoblastic_leukemia	p.R359* (No)	GDSC	FGFR_3831	1.1749
SIDM00121	ALL\|lymphoblastic_leukemia	p.R359* (No)	GDSC	AZD4547	8.3074
SIDM00121	ALL\|lymphoblastic_leukemia	p.R359* (No)	GDSC	PD173074	17.683
SIDM00121	ALL\|lymphoblastic_leukemia	p.R359* (No)	GDSC	AZD4547	10.725
SIDM00108	SKCM\|melanoma	p.V834I (No)	GDSC	PD173074	35.8564
SIDM00108	SKCM\|melanoma	p.V834I (No)	GDSC	AZD4547	11.073
SIDM00108	SKCM\|melanoma	p.V834I (No)	GDSC	FGFR_3831	37.2997
SIDM00108	SKCM\|melanoma	p.V834I (No)	GDSC	AZD4547	8.6181
SIDM00108	SKCM\|melanoma	p.V834I (No)	GDSC	PD173074	229.87
SIDM00108	SKCM\|melanoma	p.V834I (No)	GDSC	AZD4547	43.442
SIDM01181	LIHC\|liver	p.G65R (No)	GDSC	PD173074	22.7028
SIDM01181	LIHC\|liver	p.G65R (No)	GDSC	AZD4547	19.9266
SIDM01181	LIHC\|liver	p.G65R (No)	GDSC	FGFR_3831	5.1488
SIDM01181	LIHC\|liver	p.G65R (No)	GDSC	AZD4547	4.1705
SIDM01181	LIHC\|liver	p.G65R (No)	GDSC	PD173074	104.02
SIDM01181	LIHC\|liver	p.G65R (No)	GDSC	AZD4547	9.3728
SIDM00174	HNSC\|head_and_neck	p.V266G (No)	GDSC	PD173074	13.916
SIDM00174	HNSC\|head_and_neck	p.V266G (No)	GDSC	AZD4547	10.906
SIDM00174	HNSC\|head_and_neck	p.V266G (No)	GDSC	FGFR_3831	4.6052
SIDM00174	HNSC\|head_and_neck	p.V266G (No)	GDSC	AZD4547	5.3027
SIDM00174	HNSC\|head_and_neck	p.V266G (No)	GDSC	PD173074	12.009
SIDM00174	HNSC\|head_and_neck	p.V266G (No)	GDSC	AZD4547	1.2254
SIDM01051	UNCLASSIFIED\|ovary	p.A374T (No)	GDSC	PD173074	11.2634
SIDM01051	UNCLASSIFIED\|ovary	p.A374T (No)	GDSC	AZD4547	16.5801
SIDM01051	UNCLASSIFIED\|ovary	p.A374T (No)	GDSC	FGFR_3831	1.0641
SIDM01051	UNCLASSIFIED\|ovary	p.A374T (No)	GDSC	AZD4547	0.0435
SIDM00591	HNSC\|head_and_neck	p.G65R (No)	GDSC	PD173074	19.0718
SIDM00591	HNSC\|head_and_neck	p.G65R (No)	GDSC	AZD4547	18.3917
SIDM00591	HNSC\|head_and_neck	p.G65R (No)	GDSC	FGFR_3831	9.6269
SIDM00591	HNSC\|head_and_neck	p.G65R (No)	GDSC	AZD4547	8.771
SIDM00591	HNSC\|head_and_neck	p.G65R (No)	GDSC	PD173074	7.5719
SIDM00591	HNSC\|head_and_neck	p.G65R (No)	GDSC	AZD4547	24.203
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	PD173074	24.9616
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	AZD4547	26.9896
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	FGFR_3831	24.9073
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	AZD4547	4.2987
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	PD173074	43.608
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	AZD4547	5.5316
SIDM00945	COREAD\|large_intestine	p.V630M (No)	GDSC	PD173074	66.9404
SIDM00945	COREAD\|large_intestine	p.V630M (No)	GDSC	AZD4547	140.9982
SIDM00945	COREAD\|large_intestine	p.V630M (No)	GDSC	FGFR_3831	6.1426
SIDM00945	COREAD\|large_intestine	p.V630M (No)	GDSC	AZD4547	18.6265
SIDM00945	COREAD\|large_intestine	p.V630M (No)	GDSC	AZD4547	42.931
SIDM00945	COREAD\|large_intestine	p.E122K (No)	GDSC	PD173074	66.9404
SIDM00945	COREAD\|large_intestine	p.E122K (No)	GDSC	AZD4547	140.9982
SIDM00945	COREAD\|large_intestine	p.E122K (No)	GDSC	FGFR_3831	6.1426
SIDM00945	COREAD\|large_intestine	p.E122K (No)	GDSC	AZD4547	18.6265
SIDM00945	COREAD\|large_intestine	p.E122K (No)	GDSC	AZD4547	42.931
SIDM00498	COREAD\|large_intestine	p.P778H (Yes)	GDSC	PD173074	37.3246
SIDM00498	COREAD\|large_intestine	p.P778H (Yes)	GDSC	AZD4547	99.762
SIDM00498	COREAD\|large_intestine	p.P778H (Yes)	GDSC	FGFR_3831	59.5653
SIDM00498	COREAD\|large_intestine	p.P778H (Yes)	GDSC	AZD4547	16.0237
SIDM00498	COREAD\|large_intestine	p.P778H (Yes)	GDSC	PD173074	44.671
SIDM00498	COREAD\|large_intestine	p.P778H (Yes)	GDSC	AZD4547	76.354
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G103fs*13 (No)	GDSC	PD173074	4.6704
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G103fs*13 (No)	GDSC	AZD4547	6.7207
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G103fs*13 (No)	GDSC	FGFR_3831	5.089
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G103fs*13 (No)	GDSC	AZD4547	8.8687
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G103fs*13 (No)	GDSC	PD173074	41.987
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.G103fs*13 (No)	GDSC	AZD4547	3.4416
SIDM00529	BRCA\|breast	p.G44S (No)	GDSC	PD173074	10.4897
SIDM00529	BRCA\|breast	p.G44S (No)	GDSC	AZD4547	44.5142
SIDM00529	BRCA\|breast	p.G44S (No)	GDSC	FGFR_3831	31.0257
SIDM00529	BRCA\|breast	p.G44S (No)	GDSC	AZD4547	11.2651
SIDM00529	BRCA\|breast	p.G44S (No)	GDSC	PD173074	72.481
SIDM00529	BRCA\|breast	p.G44S (No)	GDSC	AZD4547	20.239
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.T79S (No)	GDSC	PD173074	32.5031
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.T79S (No)	GDSC	AZD4547	21.4374
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.T79S (No)	GDSC	FGFR_3831	12.0986
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.T79S (No)	GDSC	AZD4547	10.3675
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.T79S (No)	GDSC	PD173074	73.698
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.T79S (No)	GDSC	AZD4547	48.518
SIDM01028	ESCA\|oesophagus	p.G65R (No)	GDSC	PD173074	24.6282
SIDM01028	ESCA\|oesophagus	p.G65R (No)	GDSC	AZD4547	26.6499
SIDM01028	ESCA\|oesophagus	p.G65R (No)	GDSC	FGFR_3831	25.2391
SIDM01028	ESCA\|oesophagus	p.G65R (No)	GDSC	PD173074	329.48
SIDM01028	ESCA\|oesophagus	p.G65R (No)	GDSC	AZD4547	39.9
SIDM00999	BLCA\|bladder	p.R248C (No)	GDSC	PD173074	5.3505
SIDM00999	BLCA\|bladder	p.R248C (No)	GDSC	AZD4547	38.7847
SIDM00999	BLCA\|bladder	p.R248C (No)	GDSC	FGFR_3831	5.2316
SIDM00999	BLCA\|bladder	p.R248C (No)	GDSC	AZD4547	8.0354
SIDM00999	BLCA\|bladder	p.R248C (No)	GDSC	PD173074	26.793
SIDM00999	BLCA\|bladder	p.R248C (No)	GDSC	AZD4547	4.6515
SIDM00140	SKCM\|melanoma	p.P62L (No)	GDSC	PD173074	35.9563
SIDM00140	SKCM\|melanoma	p.P62L (No)	GDSC	AZD4547	23.8191
SIDM00140	SKCM\|melanoma	p.P62L (No)	GDSC	FGFR_3831	47.3548
SIDM00140	SKCM\|melanoma	p.P62L (No)	GDSC	AZD4547	4.5991
SIDM00140	SKCM\|melanoma	p.P62L (No)	GDSC	PD173074	75.114
SIDM00140	SKCM\|melanoma	p.P62L (No)	GDSC	AZD4547	4.8212
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.S736Y (No)	GDSC	PD173074	4.7145
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.S736Y (No)	GDSC	AZD4547	12.5458
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.S736Y (No)	GDSC	FGFR_3831	9.6759
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.S736Y (No)	GDSC	AZD4547	13.9238
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.S736Y (No)	GDSC	PD173074	85.834
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.S736Y (No)	GDSC	AZD4547	37.855
SIDM00839	COREAD\|large_intestine	p.I532V (No)	GDSC	PD173074	16.0519
SIDM00839	COREAD\|large_intestine	p.I532V (No)	GDSC	AZD4547	28.8397
SIDM00839	COREAD\|large_intestine	p.I532V (No)	GDSC	FGFR_3831	38.5556
SIDM00839	COREAD\|large_intestine	p.I532V (No)	GDSC	AZD4547	12.3397
SIDM00839	COREAD\|large_intestine	p.I532V (No)	GDSC	PD173074	91.526
SIDM00839	COREAD\|large_intestine	p.I532V (No)	GDSC	AZD4547	9.1111
SIDM00216	COREAD\|large_intestine	p.T689M (No)	GDSC	PD173074	48.945
SIDM00216	COREAD\|large_intestine	p.T689M (No)	GDSC	AZD4547	8.4295
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.R359P (No)	GDSC	PD173074	8.2922
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.R359P (No)	GDSC	AZD4547	4.7361
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.R359P (No)	GDSC	FGFR_3831	67.6987
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.R359P (No)	GDSC	AZD4547	13.2102
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.R359P (No)	GDSC	PD173074	15.213
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.R359P (No)	GDSC	AZD4547	22.192
SIDM00282	COREAD\|large_intestine	p.G65R (No)	GDSC	PD173074	50.1085
SIDM00282	COREAD\|large_intestine	p.G65R (No)	GDSC	AZD4547	293.7118
SIDM00282	COREAD\|large_intestine	p.G65R (No)	GDSC	FGFR_3831	250.0093
SIDM00282	COREAD\|large_intestine	p.G65R (No)	GDSC	AZD4547	19.8521
SIDM00282	COREAD\|large_intestine	p.G65R (No)	GDSC	PD173074	36.484
SIDM00282	COREAD\|large_intestine	p.G65R (No)	GDSC	AZD4547	260.29
SIDM00150	COREAD\|large_intestine	p.E332K (No)	GDSC	PD173074	21.0757
SIDM00150	COREAD\|large_intestine	p.E332K (No)	GDSC	AZD4547	0.3941
SIDM00150	COREAD\|large_intestine	p.E332K (No)	GDSC	FGFR_3831	148.5934
SIDM00150	COREAD\|large_intestine	p.E332K (No)	GDSC	AZD4547	1.8301
SIDM00150	COREAD\|large_intestine	p.E332K (No)	GDSC	PD173074	85.978
SIDM00150	COREAD\|large_intestine	p.E332K (No)	GDSC	AZD4547	0.1982
SIDM00928	BRCA\|breast	p.Q161K (No)	GDSC	PD173074	61.5662
SIDM00928	BRCA\|breast	p.Q161K (No)	GDSC	AZD4547	48.4302
SIDM00928	BRCA\|breast	p.Q161K (No)	GDSC	FGFR_3831	52.5738
SIDM00928	BRCA\|breast	p.Q161K (No)	GDSC	AZD4547	9.5834
SIDM00928	BRCA\|breast	p.Q161K (No)	GDSC	PD173074	204.7
SIDM00928	BRCA\|breast	p.Q161K (No)	GDSC	AZD4547	71.391
SIDM01000	SKCM\|melanoma	p.P402L (No)	GDSC	PD173074	9.0602
SIDM01000	SKCM\|melanoma	p.P402L (No)	GDSC	AZD4547	96.2267
SIDM01000	SKCM\|melanoma	p.P402L (No)	GDSC	FGFR_3831	51.8836
SIDM01000	SKCM\|melanoma	p.P402L (No)	GDSC	AZD4547	23.1167
SIDM01000	SKCM\|melanoma	p.P402L (No)	GDSC	PD173074	111.43
SIDM01000	SKCM\|melanoma	p.P402L (No)	GDSC	AZD4547	94.782
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V321A (No)	GDSC	PD173074	17.5879
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V321A (No)	GDSC	AZD4547	7.0484
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V321A (No)	GDSC	FGFR_3831	14.9865
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V321A (No)	GDSC	AZD4547	5.5019
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V321A (No)	GDSC	PD173074	9.2098
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V321A (No)	GDSC	AZD4547	6.9866
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G103fs*13 (No)	GDSC	PD173074	8.513
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G103fs*13 (No)	GDSC	AZD4547	99.382
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G103fs*13 (No)	GDSC	FGFR_3831	45.9587
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G103fs*13 (No)	GDSC	AZD4547	33.6758
SIDM00257	NB\|neuroblastoma	p.D580N (No)	GDSC	PD173074	18.6257
SIDM00257	NB\|neuroblastoma	p.D580N (No)	GDSC	AZD4547	11.3194
SIDM00257	NB\|neuroblastoma	p.D580N (No)	GDSC	FGFR_3831	21.1446
SIDM00257	NB\|neuroblastoma	p.D580N (No)	GDSC	AZD4547	8.1187
SIDM00257	NB\|neuroblastoma	p.D580N (No)	GDSC	PD173074	16.191
SIDM00257	NB\|neuroblastoma	p.D580N (No)	GDSC	AZD4547	2.04
SIDM00340	MM\|myeloma	p.F384L (No)	GDSC	PD173074	11.8517
SIDM00340	MM\|myeloma	p.F384L (No)	GDSC	AZD4547	63.8682
SIDM00340	MM\|myeloma	p.F384L (No)	GDSC	FGFR_3831	77.205
SIDM00340	MM\|myeloma	p.F384L (No)	GDSC	AZD4547	5.0241
SIDM00609	KIRC\|kidney	p.G65R (No)	GDSC	PD173074	13.1841
SIDM00609	KIRC\|kidney	p.G65R (No)	GDSC	AZD4547	33.0204
SIDM00609	KIRC\|kidney	p.G65R (No)	GDSC	FGFR_3831	24.7187
SIDM00609	KIRC\|kidney	p.G65R (No)	GDSC	AZD4547	2.9625
SIDM00609	KIRC\|kidney	p.G65R (No)	GDSC	PD173074	100.27
SIDM00609	KIRC\|kidney	p.G65R (No)	GDSC	AZD4547	6.7754
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.P550H (No)	GDSC	PD173074	18.0801
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.P550H (No)	GDSC	AZD4547	8.3507
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.P550H (No)	GDSC	FGFR_3831	77.6246
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.P550H (No)	GDSC	AZD4547	8.4025
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.P550H (No)	GDSC	PD173074	4.9084
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.P550H (No)	GDSC	AZD4547	3.8606
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.D77N (No)	GDSC	PD173074	74.0172
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.D77N (No)	GDSC	AZD4547	427.9494
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.D77N (No)	GDSC	FGFR_3831	234.6272
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.D77N (No)	GDSC	AZD4547	31.6269
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.D77N (No)	GDSC	PD173074	409.48
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.D77N (No)	GDSC	AZD4547	255.6
SIDM00217	COREAD\|large_intestine	p.K403fs*93 (No)	GDSC	FGFR_3831	59.9387
SIDM00217	COREAD\|large_intestine	p.K403fs*93 (No)	GDSC	AZD4547	23.8098
SIDM00217	COREAD\|large_intestine	p.K403fs*93 (No)	GDSC	AZD4547	58.886
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R151Q (No)	GDSC	PD173074	22.4241
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R151Q (No)	GDSC	AZD4547	32.3485
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R151Q (No)	GDSC	FGFR_3831	6.9506
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R151Q (No)	GDSC	AZD4547	10.1606
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R151Q (No)	GDSC	PD173074	61.751
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R151Q (No)	GDSC	AZD4547	12.123
SIDM00407	DLBC\|B_cell_lymphoma	p.V266G (No)	GDSC	PD173074	7.5389
SIDM00407	DLBC\|B_cell_lymphoma	p.V266G (No)	GDSC	AZD4547	4.7367
SIDM00407	DLBC\|B_cell_lymphoma	p.V266G (No)	GDSC	FGFR_3831	28.6997
SIDM00407	DLBC\|B_cell_lymphoma	p.V266G (No)	GDSC	AZD4547	3.9851
SIDM00407	DLBC\|B_cell_lymphoma	p.V266G (No)	GDSC	PD173074	10.383
SIDM00407	DLBC\|B_cell_lymphoma	p.V266G (No)	GDSC	AZD4547	4.5421
SIDM00290	STAD\|stomach	p.G65R (No)	GDSC	PD173074	5.7419
SIDM00290	STAD\|stomach	p.G65R (No)	GDSC	AZD4547	5.1234
SIDM00290	STAD\|stomach	p.G65R (No)	GDSC	AZD4547	6.0558
SIDM00290	STAD\|stomach	p.G65R (No)	GDSC	PD173074	34.638
SIDM00290	STAD\|stomach	p.G65R (No)	GDSC	AZD4547	7.608
SIDM00446	LAML\|acute_myeloid_leukaemia	p.V266G (No)	GDSC	PD173074	7.0982
SIDM00446	LAML\|acute_myeloid_leukaemia	p.V266G (No)	GDSC	AZD4547	9.0943
SIDM00446	LAML\|acute_myeloid_leukaemia	p.V266G (No)	GDSC	FGFR_3831	3.0981
SIDM00446	LAML\|acute_myeloid_leukaemia	p.V266G (No)	GDSC	AZD4547	2.7252
SIDM00446	LAML\|acute_myeloid_leukaemia	p.V266G (No)	GDSC	PD173074	15.159
SIDM00446	LAML\|acute_myeloid_leukaemia	p.V266G (No)	GDSC	AZD4547	1.9505
SIDM00328	ESCA\|oesophagus	p.G561S (No)	GDSC	PD173074	2.975
SIDM00328	ESCA\|oesophagus	p.G561S (No)	GDSC	AZD4547	36.6929
SIDM00328	ESCA\|oesophagus	p.G561S (No)	GDSC	FGFR_3831	203.3188
SIDM00328	ESCA\|oesophagus	p.G561S (No)	GDSC	AZD4547	15.0464
SIDM00328	ESCA\|oesophagus	p.G561S (No)	GDSC	PD173074	48.999
SIDM00328	ESCA\|oesophagus	p.G561S (No)	GDSC	AZD4547	7.9718
SIDM00949	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V266G (No)	GDSC	PD173074	6.7288
SIDM00949	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V266G (No)	GDSC	AZD4547	4.2982
SIDM00949	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V266G (No)	GDSC	FGFR_3831	17.2979
SIDM00949	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V266G (No)	GDSC	AZD4547	7.0576
SIDM00949	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V266G (No)	GDSC	PD173074	5.4031
SIDM00949	UNCLASSIFIED\|lymphoid_neoplasm_other	p.V266G (No)	GDSC	AZD4547	1.3902
SIDM00528	BRCA\|breast	p.Q132H (No)	GDSC	PD173074	25.6764
SIDM00528	BRCA\|breast	p.Q132H (No)	GDSC	AZD4547	133.0736
SIDM00528	BRCA\|breast	p.Q132H (No)	GDSC	FGFR_3831	49.8666
SIDM00528	BRCA\|breast	p.Q132H (No)	GDSC	AZD4547	12.5764
SIDM00528	BRCA\|breast	p.Q132H (No)	GDSC	PD173074	62.907
SIDM00528	BRCA\|breast	p.Q132H (No)	GDSC	AZD4547	14.636
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.R568W (No)	GDSC	PD173074	19.0852
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.R568W (No)	GDSC	AZD4547	109.9556
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.R568W (No)	GDSC	FGFR_3831	59.0465
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.R568W (No)	GDSC	AZD4547	17.0163
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.R568W (No)	GDSC	PD173074	90.585
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.R568W (No)	GDSC	AZD4547	14.012
SIDM00803	KIRC\|kidney	p.V266G (No)	GDSC	PD173074	17.7385
SIDM00803	KIRC\|kidney	p.V266G (No)	GDSC	AZD4547	68.9815
SIDM00803	KIRC\|kidney	p.V266G (No)	GDSC	FGFR_3831	11.9031
SIDM00803	KIRC\|kidney	p.V266G (No)	GDSC	AZD4547	11.1157
SIDM00803	KIRC\|kidney	p.V266G (No)	GDSC	PD173074	35.302
SIDM00803	KIRC\|kidney	p.V266G (No)	GDSC	AZD4547	64.608
SIDM00815	OV\|ovary	p.P763S (No)	GDSC	PD173074	41.1684
SIDM00815	OV\|ovary	p.P763S (No)	GDSC	AZD4547	322.342
SIDM00815	OV\|ovary	p.P763S (No)	GDSC	FGFR_3831	95.5799
SIDM00815	OV\|ovary	p.P763S (No)	GDSC	AZD4547	23.4444
SIDM01169	OV\|ovary	p.K403fs*29 (No)	GDSC	PD173074	9.6885
SIDM01169	OV\|ovary	p.K403fs*29 (No)	GDSC	AZD4547	10.5139
SIDM01169	OV\|ovary	p.K403fs*29 (No)	GDSC	FGFR_3831	4.3072
SIDM01169	OV\|ovary	p.K403fs*29 (No)	GDSC	AZD4547	13.0923
SIDM01169	OV\|ovary	p.K403fs*29 (No)	GDSC	PD173074	32.4
SIDM01169	OV\|ovary	p.K403fs*29 (No)	GDSC	AZD4547	55.769
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.Q161* (No)	GDSC	PD173074	1.253
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.Q161* (No)	GDSC	AZD4547	1.0583
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.Q161* (No)	GDSC	FGFR_3831	1.6543
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.Q161* (No)	GDSC	AZD4547	0.2387
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.Q161* (No)	GDSC	PD173074	2.6095
SIDM00367	SCLC\|lung_small_cell_carcinoma	p.Q161* (No)	GDSC	AZD4547	0.4422
SIDM00457	MM\|myeloma	p.K650E (No)	GDSC	PD173074	0.5689
SIDM00457	MM\|myeloma	p.K650E (No)	GDSC	AZD4547	0.679
SIDM00457	MM\|myeloma	p.K650E (No)	GDSC	FGFR_3831	11.609
SIDM00457	MM\|myeloma	p.K650E (No)	GDSC	AZD4547	1.5178
SIDM00457	MM\|myeloma	p.K650E (No)	GDSC	PD173074	0.5241
SIDM00457	MM\|myeloma	p.K650E (No)	GDSC	AZD4547	0.2715
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.G103fs*13 (No)	GDSC	PD173074	15.9852
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.G103fs*13 (No)	GDSC	AZD4547	18.9614
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.G103fs*13 (No)	GDSC	FGFR_3831	17.7852
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.G103fs*13 (No)	GDSC	AZD4547	12.3313
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.G103fs*13 (No)	GDSC	PD173074	21.672
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.G103fs*13 (No)	GDSC	AZD4547	4.3
SIDM00693	BLCA\|bladder	p.K650E (No)	GDSC	PD173074	4.9952
SIDM00693	BLCA\|bladder	p.K650E (No)	GDSC	AZD4547	34.5488
SIDM00693	BLCA\|bladder	p.K650E (No)	GDSC	FGFR_3831	20.1949
SIDM00693	BLCA\|bladder	p.K650E (No)	GDSC	AZD4547	5.7221
SIDM00693	BLCA\|bladder	p.K650E (No)	GDSC	PD173074	251.69
SIDM00693	BLCA\|bladder	p.K650E (No)	GDSC	AZD4547	3.9361
SIDM00608	MM\|myeloma	p.Y373C (No)	GDSC	PD173074	9.0584
SIDM00608	MM\|myeloma	p.Y373C (No)	GDSC	AZD4547	11.7443
SIDM00608	MM\|myeloma	p.Y373C (No)	GDSC	FGFR_3831	4.8221
SIDM00608	MM\|myeloma	p.Y373C (No)	GDSC	AZD4547	1.6561

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MTQ0	Homeobox protein notochord	DEG_SPOP_SBC_1	232:236	PSSSS	SPOP	0.9058	More...
O15040	Tectonin beta-propeller repeat-containing protein 2	DEG_SPOP_SBC_1	763:767	PSSSS	SPOP	0.9823	More...
O15146	Muscle, skeletal receptor tyrosine-protein kinase	DEG_SPOP_SBC_1	479:483	PSSSS	SPOP	0.8323	More...
O15197	Ephrin type-B receptor 6	DEG_SPOP_SBC_1	165:169	PSSSS	SPOP	0.6462	More...
O15209	Zinc finger and BTB domain-containing protein 22	DEG_SPOP_SBC_1	430:434	PSSSS	SPOP	0.9122	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	841:845	PSSSS	SPOP	0.9975	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	39:43	PSSSS	SPOP	0.972	More...
O15524	Suppressor of cytokine signaling 1	DEG_SPOP_SBC_1	25:29	PSSSS	SPOP	0.9817	More...
O43298	Zinc finger and BTB domain-containing protein 43	DEG_SPOP_SBC_1	143:147	PSSSS	SPOP	0.9926	More...
O43426	Synaptojanin-1	DEG_SPOP_SBC_1	1032:1036	PSSSS	SPOP	0.9976	More...
O43900	Prickle planar cell polarity protein 3	DEG_SPOP_SBC_1	549:553	PSSSS	SPOP	0.9245	More...
O60307	Microtubule-associated serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	1142:1146	PSSSS	SPOP	0.9881	More...
O60318	Germinal-center associated nuclear protein	DEG_SPOP_SBC_1	99:103	PSSSS	SPOP	0.9421	More...
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1115:1119	PSSSS	SPOP	0.9486	More...
O75052	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	DEG_SPOP_SBC_1	272:276	PSSSS	SPOP	0.9973	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1276:1280	PSSSS	SPOP	0.9293	More...
O94885	SAM and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	336:340	PSSSS	SPOP	0.9977	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	290:294	PSSSS	SPOP	0.9979	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	DEG_SPOP_SBC_1	129:133	PSSSS	SPOP	0.9965	More...
O95716	Ras-related protein Rab-3D	DEG_SPOP_SBC_1	193:197	PSSSS	SPOP	0.7948	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1144:1148	PSSSS	SPOP	0.9971	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1872:1876	PSSSS	SPOP	0.9707	More...
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	231:235	PSSSS	SPOP	0.98	More...
P20393	Nuclear receptor subfamily 1 group D member 1	DEG_SPOP_SBC_1	81:85	PSSSS	SPOP	0.9588	More...
P22607	Fibroblast growth factor receptor 3	DEG_SPOP_SBC_1	778:782	PSSSS	SPOP	0.9964	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	832:836	PSSSS	SPOP	0.995	More...
P29120	Neuroendocrine convertase 1	DEG_SPOP_SBC_1	646:650	PSSSS	SPOP	0.8406	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_SPOP_SBC_1	1242:1246	PSSSS	SPOP	0.9873	More...
P30405	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	DEG_SPOP_SBC_1	37:41	PSSSS	SPOP	0.8163	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	679:683	PSSSS	SPOP	0.9979	More...
P38432	Coilin	DEG_SPOP_SBC_1	244:248	PSSSS	SPOP	0.9884	More...
P45983	Mitogen-activated protein kinase 8	DEG_SPOP_SBC_1	390:394	PSSSS	SPOP	0.988	More...
P48751	Anion exchange protein 3	DEG_SPOP_SBC_1	441:445	PSSSS	SPOP	0.9863	More...
P48995	Short transient receptor potential channel 1	DEG_SPOP_SBC_1	23:27	PSSSS	SPOP	0.8905	More...
P55201	Peregrin	DEG_SPOP_SBC_1	950:954	PSSSS	SPOP	0.9386	More...
Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	DEG_SPOP_SBC_1	2117:2121	PSSSS	SPOP	0.9923	More...
Q01538	Myelin transcription factor 1	DEG_SPOP_SBC_1	684:688	PSSSS	SPOP	0.9826	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	358:362	PSSSS	SPOP	0.8546	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	101:105	PSSSS	SPOP	0.9367	More...
Q12837	POU domain, class 4, transcription factor 2	DEG_SPOP_SBC_1	47:51	PSSSS	SPOP	0.9987	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	698:702	PSSSS	SPOP	0.9524	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	1568:1572	PSSSS	SPOP	0.9832	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	146:150	PSSSS	SPOP	0.9966	More...
Q14694	Ubiquitin carboxyl-terminal hydrolase 10	DEG_SPOP_SBC_1	351:355	PSSSS	SPOP	0.9991	More...
Q15070	Mitochondrial inner membrane protein OXA1L	DEG_SPOP_SBC_1	418:422	PSSSS	SPOP	0.9452	More...
Q16585	Beta-sarcoglycan	DEG_SPOP_SBC_1	269:273	PSSSS	SPOP	0.5268	More...
Q17R98	Zinc finger protein 827	DEG_SPOP_SBC_1	966:970	PSSSS	SPOP	0.9308	More...
Q3MII6	TBC1 domain family member 25	DEG_SPOP_SBC_1	560:564	PSSSS	SPOP	0.9952	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1281:1285	PSSSS	SPOP	0.6698	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	939:943	PSSSS	SPOP	0.9287	More...
Q58A45	PAN2-PAN3 deadenylation complex subunit PAN3	DEG_SPOP_SBC_1	16:20	PSSSS	SPOP	0.9796	More...
Q59H18	Serine/threonine-protein kinase TNNI3K	DEG_SPOP_SBC_1	742:746	PSSSS	SPOP	0.9797	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	6363:6367	PSSSS	SPOP	0.9426	More...
Q6GYQ0	Ral GTPase-activating protein subunit alpha-1	DEG_SPOP_SBC_1	378:382	PSSSS	SPOP	0.9981	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	446:450	PSSSS	SPOP	0.9956	More...
Q6P2E9	Enhancer of mRNA-decapping protein 4	DEG_SPOP_SBC_1	612:616	PSSSS	SPOP	0.9966	More...
Q6Q0C0	E3 ubiquitin-protein ligase TRAF7	DEG_SPOP_SBC_1	60:64	PSSSS	SPOP	0.9996	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	251:255	PSSSS	SPOP	0.8853	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2217:2221	PSSSS	SPOP	0.9687	More...
Q6ZUT1	Uncharacterized protein NKAPD1	DEG_SPOP_SBC_1	53:57	PSSSS	SPOP	0.997	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	1070:1074	PSSSS	SPOP	0.8717	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	453:457	PSSSS	SPOP	0.9938	More...
Q765P7	Protein MTSS 2	DEG_SPOP_SBC_1	265:269	PSSSS	SPOP	0.7755	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	531:535	PSSSS	SPOP	0.864	More...
Q7KZ85	Transcription elongation factor SPT6	DEG_SPOP_SBC_1	1524:1528	PSSSS	SPOP	0.9296	More...
Q7KZ85	Transcription elongation factor SPT6	DEG_SPOP_SBC_1	1653:1657	PSSSS	SPOP	0.989	More...
Q8HWS3	DNA-binding protein RFX6	DEG_SPOP_SBC_1	879:883	PSSSS	SPOP	0.889	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1254:1258	PSSSS	SPOP	0.5133	More...
Q8IWT3	Cullin-9	DEG_SPOP_SBC_1	579:583	PSSSS	SPOP	0.9855	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	2295:2299	PSSSS	SPOP	0.9846	More...
Q8IX15	Homeobox and leucine zipper protein Homez	DEG_SPOP_SBC_1	283:287	PSSSS	SPOP	0.9911	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	202:206	PSSSS	SPOP	0.9944	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	151:155	PSSSS	SPOP	0.9715	More...
Q8IZD9	Dedicator of cytokinesis protein 3	DEG_SPOP_SBC_1	1740:1744	PSSSS	SPOP	0.9951	More...
Q8N1F7	Nuclear pore complex protein Nup93	DEG_SPOP_SBC_1	768:772	PSSSS	SPOP	0.7728	More...
Q8N5G2	Macoilin	DEG_SPOP_SBC_1	344:348	PSSSS	SPOP	0.9634	More...
Q8NE35	Cytoplasmic polyadenylation element-binding protein 3	DEG_SPOP_SBC_1	220:224	PSSSS	SPOP	0.8709	More...
Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	DEG_SPOP_SBC_1	24:28	PSSSS	SPOP	0.9971	More...
Q8NI27	THO complex subunit 2	DEG_SPOP_SBC_1	1208:1212	PSSSS	SPOP	0.9583	More...
Q8WUH2	Transforming growth factor-beta receptor-associated protein 1	DEG_SPOP_SBC_1	851:855	PSSSS	SPOP	0.9525	More...
Q8WUI4	Histone deacetylase 7	DEG_SPOP_SBC_1	199:203	PSSSS	SPOP	0.9441	More...
Q8WX93	Palladin	DEG_SPOP_SBC_1	756:760	PSSSS	SPOP	0.999	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	301:305	PSSSS	SPOP	0.6405	More...
Q96F45	Zinc finger protein 503	DEG_SPOP_SBC_1	556:560	PSSSS	SPOP	0.984	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1270:1274	PSSSS	SPOP	0.9193	More...
Q99102	Mucin-4	DEG_SPOP_SBC_1	3702:3706	PSSSS	SPOP	0.941	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	214:218	PSSSS	SPOP	0.7612	More...
Q9BWQ8	Protein lifeguard 2	DEG_SPOP_SBC_1	70:74	PSSSS	SPOP	0.948	More...
Q9BYZ6	Rho-related BTB domain-containing protein 2	DEG_SPOP_SBC_1	720:724	PSSSS	SPOP	0.7707	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	1201:1205	PSSSS	SPOP	0.9775	More...
Q9H0H5	Rac GTPase-activating protein 1	DEG_SPOP_SBC_1	589:593	PSSSS	SPOP	0.9995	More...
Q9H3Q1	Cdc42 effector protein 4	DEG_SPOP_SBC_1	69:73	PSSSS	SPOP	0.9451	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	722:726	PSSSS	SPOP	0.9704	More...
Q9H6B4	CXADR-like membrane protein	DEG_SPOP_SBC_1	287:291	PSSSS	SPOP	0.9262	More...
Q9H7D7	WD repeat-containing protein 26	DEG_SPOP_SBC_1	44:48	PSSSS	SPOP	0.9923	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	201:205	PSSSS	SPOP	0.8985	More...
Q9H7Z3	Nuclear exosome regulator NRDE2	DEG_SPOP_SBC_1	104:108	PSSSS	SPOP	0.6574	More...
Q9HCG8	Pre-mRNA-splicing factor CWC22 homolog	DEG_SPOP_SBC_1	668:672	PSSSS	SPOP	0.9061	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2080:2084	PSSSS	SPOP	0.9952	More...
Q9NP79	Vacuolar protein sorting-associated protein VTA1 homolog	DEG_SPOP_SBC_1	193:197	PSSSS	SPOP	0.9408	More...
Q9NQ75	Cas scaffolding protein family member 4	DEG_SPOP_SBC_1	273:277	PSSSS	SPOP	0.999	More...
Q9NRC6	Spectrin beta chain, non-erythrocytic 5	DEG_SPOP_SBC_1	3553:3557	PSSSS	SPOP	0.9237	More...
Q9NRL3	Striatin-4	DEG_SPOP_SBC_1	573:577	PSSSS	SPOP	0.8479	More...
Q9NVW2	E3 ubiquitin-protein ligase RLIM	DEG_SPOP_SBC_1	477:481	PSSSS	SPOP	0.9976	More...
Q9P0U3	Sentrin-specific protease 1	DEG_SPOP_SBC_1	103:107	PSSSS	SPOP	0.9571	More...
Q9UDT6	CAP-Gly domain-containing linker protein 2	DEG_SPOP_SBC_1	315:319	PSSSS	SPOP	0.9467	More...
Q9UHF7	Zinc finger transcription factor Trps1	DEG_SPOP_SBC_1	67:71	PSSSS	SPOP	0.997	More...
Q9UJ14	Glutathione hydrolase 7	DEG_SPOP_SBC_1	71:75	PSSSS	SPOP	0.9905	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	687:691	PSSSS	SPOP	0.7908	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	863:867	PSSSS	SPOP	0.9942	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	211:215	PSSSS	SPOP	0.9945	More...
Q9UMR3	T-box transcription factor TBX20	DEG_SPOP_SBC_1	75:79	PSSSS	SPOP	0.9839	More...
Q9Y388	RNA-binding motif protein, X-linked 2	DEG_SPOP_SBC_1	184:188	PSSSS	SPOP	0.9419	More...
Q9Y3Q4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	DEG_SPOP_SBC_1	852:856	PSSSS	SPOP	0.945	More...
Q9Y3Q4	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	DEG_SPOP_SBC_1	876:880	PSSSS	SPOP	0.9112	More...
Q9Y4X0	AMME syndrome candidate gene 1 protein	DEG_SPOP_SBC_1	108:112	PSSSS	SPOP	0.7876	More...
Q9Y6F6	Inositol 1,4,5-triphosphate receptor associated 1	DEG_SPOP_SBC_1	706:710	PSSSS	SPOP	0.7952	More...
Q9Y6N7	Roundabout homolog 1	DEG_SPOP_SBC_1	1601:1605	PSSSS	SPOP	0.9801	More...
A7MBM2	Protein dispatched homolog 2	DEG_SPOP_SBC_1	66:70	PSSSS	SPOP	0.9819	More...
P43363	Melanoma-associated antigen 10	DEG_SPOP_SBC_1	53:57	PSSSS	SPOP	0.9954	More...
Q2MJR0	Sprouty-related, EVH1 domain-containing protein 3	DEG_SPOP_SBC_1	120:124	PSSSS	SPOP	0.9463	More...
Q4G0A6	Probable ubiquitin carboxyl-terminal hydrolase MINDY-4	DEG_SPOP_SBC_1	234:238	PSSSS	SPOP	0.9862	More...
Q6PJQ5	Forkhead box protein R2	DEG_SPOP_SBC_1	132:136	PSSSS	SPOP	0.9182	More...
Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	DEG_SPOP_SBC_1	635:639	PSSSS	SPOP	0.965	More...
Q70EK8	Inactive ubiquitin carboxyl-terminal hydrolase 53	DEG_SPOP_SBC_1	999:1003	PSSSS	SPOP	0.7913	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	720:724	PSSSS	SPOP	0.9863	More...
Q96LD1	Zeta-sarcoglycan	DEG_SPOP_SBC_1	258:262	PSSSS	SPOP	0.6136	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	2191:2195	PSSSS	SPOP	0.9783	More...
Q9NR64	Kelch-like protein 1	DEG_SPOP_SBC_1	72:76	PSSSS	SPOP	0.9967	More...
Q9NR64	Kelch-like protein 1	DEG_SPOP_SBC_1	82:86	PSSSS	SPOP	0.9951	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	350:354	PSSSS	SPOP	0.9977	More...
A2CJ06	Dystrotelin	DEG_SPOP_SBC_1	388:392	PSSSS	SPOP	0.9314	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	239:243	PSSSS	SPOP	0.9332	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1461:1465	PSSSS	SPOP	0.9413	More...
Q5TF21	Protein SOGA3	DEG_SPOP_SBC_1	218:222	PSSSS	SPOP	0.8918	More...
Q5VXU3	Cysteine-rich hydrophobic domain-containing protein 1	DEG_SPOP_SBC_1	32:36	PSSSS	SPOP	0.8518	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	1089:1093	PSSSS	SPOP	0.9912	More...
Q8IXS8	Protein FAM126B	DEG_SPOP_SBC_1	366:370	PSSSS	SPOP	0.9237	More...
Q96C57	Protein CUSTOS	DEG_SPOP_SBC_1	147:151	PSSSS	SPOP	0.9565	More...
A6NKL6	Transmembrane protein 200C	DEG_SPOP_SBC_1	142:146	PSSSS	SPOP	0.7478	More...
A6NNA2	Serine/arginine repetitive matrix protein 3	DEG_SPOP_SBC_1	25:29	PSSSS	SPOP	0.6341	More...
A8MXT2	Melanoma-associated antigen B17	DEG_SPOP_SBC_1	39:43	PSSSS	SPOP	0.9755	More...
O95177	Uncharacterized protein GAS8-AS1	DEG_SPOP_SBC_1	113:117	PSSSS	SPOP	0.8372	More...
Q5VZ18	SH2 domain-containing adapter protein E	DEG_SPOP_SBC_1	162:166	PSSSS	SPOP	0.9955	More...
Q6P2S7	Putative tetratricopeptide repeat protein 41	DEG_SPOP_SBC_1	201:205	PSSSS	SPOP	0.5805	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	56:60	PSSSS	SPOP	0.8763	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	83:87	PSSSS	SPOP	0.7647	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	92:96	PSSSS	SPOP	0.8932	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	118:122	PSSSS	SPOP	0.8649	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	129:133	PSSSS	SPOP	0.8649	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	136:140	PSSSS	SPOP	0.8566	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	147:151	PSSSS	SPOP	0.8676	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	154:158	PSSSS	SPOP	0.8727	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	168:172	PSSSS	SPOP	0.7751	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	194:198	PSSSS	SPOP	0.6915	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	208:212	PSSSS	SPOP	0.7	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	223:227	PSSSS	SPOP	0.7624	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	228:232	PSSSS	SPOP	0.742	More...
Q9H693	Uncharacterized protein C16orf95	DEG_SPOP_SBC_1	133:137	PSSSS	SPOP	0.6485	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSSS

Degron related mutations and impact score

Drug responses associated with FGFR3 mutations

All proteins holding degron of PSSSS