DegronMD

Uniprot ID: P22607

Source protein: Fibroblast growth factor receptor 3

Source gene: FGFR3

Class: DEG_SPOP_SBC_1

Location: 778:782

E3 ligase: SPOP

DEGRON score: 0.9964

ASA_SCORE: 85.36

COIL: 0.9574

CONS_SCORE: 0.4495

DSS_SCORE: 0.7664

HELIX: 0.0246

FCONS_SCORE: 1.1197

RIG_SCORE: 0.5088

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P780H	SIDM00498	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.7694
p.P780H	SNU-C5	large_intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.7694
p.P778H	ACH-000970	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.7694
p.P778H	SNU-C5	large_intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	0.7694
p.S781R	TCGA-53-7813	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	0.7427
p.S781R	DO24349	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	0.7427
p.T779N	DO233892	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.7055
p.S771F	ACH-000384	Bladder Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.5833
p.V784M	DO10443	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	0.2778
p.G774S	DO37782	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	0.2222
p.S773F	SIDM01160	Bladder Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	0.1944
p.D788N	TCGA-CV-5442	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	0.1667
p.D788N	DO14678	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1667
p.S789F	TCGA-EE-A2A2	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	0.1389
p.S789F	DO220852	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1389
p.S789F	DO37583	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	0.1389
p.F769L	DO222431	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.0833
p.A792V	DO229084	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	0.0556
p.P768T	ACH-001061	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 19 of 19 entries

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Drug responses associated with FGFR3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	PD173074	24.9616
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	AZD4547	26.9896
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	FGFR_3831	24.9073
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	AZD4547	4.2987
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	PD173074	43.608
SIDM00814	ACC\|adrenal_gland	p.T504S (No)	GDSC	AZD4547	5.5316
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	PD173074	5.3529
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	AZD4547	5.9409
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	FGFR_3831	1.2012
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	AZD4547	1.9435
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	PD173074	36.262
SIDM00145	ALL\|lymphoblastic_leukemia	p.Y226H (No)	GDSC	AZD4547	24.727
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	PD173074	5.3529
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	AZD4547	5.9409
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	FGFR_3831	1.2012
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	AZD4547	1.9435
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	PD173074	36.262
SIDM00145	ALL\|lymphoblastic_leukemia	p.R621H (No)	GDSC	AZD4547	24.727
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	PD173074	5.3529
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	AZD4547	5.9409
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	FGFR_3831	1.2012
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	AZD4547	1.9435
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	PD173074	36.262
SIDM00145	ALL\|lymphoblastic_leukemia	p.V759I (No)	GDSC	AZD4547	24.727
SIDM00145	ALL\|lymphoblastic_leukemia	p.R712H (No)	GDSC	PD173074	5.3529

Showing 1 to 25 of 358 entries

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All proteins holding degron of PSSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1276:1280	PSSSS	SPOP	0.9293	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	698:702	PSSSS	SPOP	0.9524	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	832:836	PSSSS	SPOP	0.995	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1144:1148	PSSSS	SPOP	0.9971	More...
O95996	Adenomatous polyposis coli protein 2	DEG_SPOP_SBC_1	1872:1876	PSSSS	SPOP	0.9707	More...
Q9Y4X0	AMME syndrome candidate gene 1 protein	DEG_SPOP_SBC_1	108:112	PSSSS	SPOP	0.7876	More...
P48751	Anion exchange protein 3	DEG_SPOP_SBC_1	441:445	PSSSS	SPOP	0.9863	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	2295:2299	PSSSS	SPOP	0.9846	More...
Q9ULH1	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1	DEG_SPOP_SBC_1	863:867	PSSSS	SPOP	0.9942	More...
P29374	AT-rich interactive domain-containing protein 4A	DEG_SPOP_SBC_1	1242:1246	PSSSS	SPOP	0.9873	More...
Q4LE39	AT-rich interactive domain-containing protein 4B	DEG_SPOP_SBC_1	1281:1285	PSSSS	SPOP	0.6698	More...
Q99700	Ataxin-2	DEG_SPOP_SBC_1	214:218	PSSSS	SPOP	0.7612	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	841:845	PSSSS	SPOP	0.9975	More...
Q16585	Beta-sarcoglycan	DEG_SPOP_SBC_1	269:273	PSSSS	SPOP	0.5268	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	290:294	PSSSS	SPOP	0.9979	More...
Q9UDT6	CAP-Gly domain-containing linker protein 2	DEG_SPOP_SBC_1	315:319	PSSSS	SPOP	0.9467	More...
O75052	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein	DEG_SPOP_SBC_1	272:276	PSSSS	SPOP	0.9973	More...
Q9NQ75	Cas scaffolding protein family member 4	DEG_SPOP_SBC_1	273:277	PSSSS	SPOP	0.999	More...
Q9H3Q1	Cdc42 effector protein 4	DEG_SPOP_SBC_1	69:73	PSSSS	SPOP	0.9451	More...
Q76N32	Centrosomal protein of 68 kDa	DEG_SPOP_SBC_1	531:535	PSSSS	SPOP	0.864	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2080:2084	PSSSS	SPOP	0.9952	More...
Q8IYX3	Coiled-coil domain-containing protein 116	DEG_SPOP_SBC_1	151:155	PSSSS	SPOP	0.9715	More...
P38432	Coilin	DEG_SPOP_SBC_1	244:248	PSSSS	SPOP	0.9884	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	358:362	PSSSS	SPOP	0.8546	More...
Q92879	CUGBP Elav-like family member 1	DEG_SPOP_SBC_1	301:305	PSSSS	SPOP	0.6405	More...

Showing 1 to 25 of 159 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSSS

Degron related mutations and impact score

Drug responses associated with FGFR3 mutations

All proteins holding degron of PSSSS