DegronMD - P29374(ARID4A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K738N	TCGA-BK-A6W3	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation substituting flanking lysine	0.2778
p.K738N	DO50076	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation substituting flanking lysine	0.2778
p.S1233F	TCGA-CV-A45V	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.0833
p.S1233F	DO52059	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.0833
p.E756D	TCGA-EO-A3B0	UCEC	TCGA	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation rewiring degron network	0.1111
p.E756D	DO219773	UCEC	ICGC	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation rewiring degron network	0.1111
p.A1253T	TCGA-IB-7651	PAAD	TCGA	PSSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.1389
p.E1255Q	TCGA-IR-A3LA	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.0833
p.E1255Q	DO1132	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.0833
p.E1255Q	DO44377	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.0833
p.P1247S	TCGA-NC-A5HH	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	1242:1246	Mutation rewiring degron network	0.3056
p.P737S	SIDM00216	Colorectal Carcinoma	GDSC	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation rewiring degron network	0.1389
p.P737S	ACH-000989	Colon/Colorectal Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation rewiring degron network	0.1389
p.P737S	SNU-175	large intestine	COSMIC	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation rewiring degron network	0.1389
p.Q751K	SIDM00887	Other Solid Cancers	GDSC	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation rewiring degron network	0.25
p.Q751K	ACH-000211	Brain Cancer	CCLE	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation rewiring degron network	0.25
p.Q751K	Daoy	central nervous system	COSMIC	LKEND	DEG_APCC_KENBOX_2	744:748	Mutation rewiring degron network	0.25
p.P1242H	ACH-001061	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1242:1246	Mutation altering degron motif	0.7694

Kaplan plot for ARID4A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARID4A

UniProt ID: P29374

Entrez ID: 5926

Protein name: AT-rich interactive domain-containing protein 4A (ARID domain-containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARID4A in