DegronMD - Q9H3Q1(CDC42EP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R107L	TCGA-37-3789	LUSC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.7316
p.R107L	TCGA-D3-A2JL	SKCM	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.7316
p.R107L	DO26743	LUSC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.7316
p.R107L	DO47278	SKCM	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.7316
p.S77G	TCGA-66-2781	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation blocking phosphorylation signal	0.6667
p.S77G	DO26422	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation blocking phosphorylation signal	0.6667
p.R94S	TCGA-95-7567	LUAD	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation rewiring degron network	0.1944
p.R94S	DO25564	LUAD	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation rewiring degron network	0.1944
p.S109L	TCGA-A5-A0G2	UCEC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation blocking phosphorylation signal	0.7222
p.S109L	TCGA-MA-AA41	CESC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation blocking phosphorylation signal	0.7222
p.S109L	DO219723	CESC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation blocking phosphorylation signal	0.7222
p.S109L	DO41235	UCEC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation blocking phosphorylation signal	0.7222
p.E96G	TCGA-CK-6747	COAD	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation rewiring degron network	0.25
p.E96G	DO10156	COAD	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation rewiring degron network	0.25
p.S91L	TCGA-CN-4739	HNSC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation blocking phosphorylation signal	0.5556
p.S91L	DO14478	HNSC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation blocking phosphorylation signal	0.5556
p.R76H	TCGA-D1-A17D	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R76H	DO41746	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.E67K	TCGA-HD-A633	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.2778
p.E67K	DO49061	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.2778
p.R97Q	TCGA-PG-A6IB	UCEC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation rewiring degron network	0.2778
p.R97Q	DO52419	UCEC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation rewiring degron network	0.2778
p.A116V	DO227976	COCA	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation rewiring degron network	0.0833
p.A116V	DO220878	MELA	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation rewiring degron network	0.0833
p.G61R	DO233731	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1111
p.L77F	DO220851	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation blocking phosphorylation signal	0.6667
p.R76C	DO35442	PACA	ICGC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.G62C	DO36062	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.H78Y	DO219482	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944
p.M102I	DO229250	THCA	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.6507
p.R100H	SIDM00958	Chronic Myelogenous Leukemia	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.8244
p.R100H	ACH-000920	Leukemia	CCLE	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.8244
p.M102V	SIDM00656	Burkitt's Lymphoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.6097
p.M102V	SIDM00849	Kidney Carcinoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.6097
p.M102V	SIDM01107	Melanoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.6097
p.M102V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.6097
p.M102V	SIDM01173	Rhabdomyosarcoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.6097
p.M102V	SIDM00641	Burkitt's Lymphoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	99:107	Mutation altering degron motif	0.6097
p.F83L	SIDM00449	B-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.F83L	ACH-000922	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.F83L	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.E59K	SIDM00537	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.E59K	ACH-000982	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.E59K	ACH-001345	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.E59K	GP5d	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.G62S	SIDM01000	Melanoma	GDSC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.G62S	ACH-000304	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.G62S	WM-115	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.S70C	SIDM01412	Oral Cavity Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.7541
p.S70C	ACH-000762	Head and Neck Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.7541
p.H78R	GP5d	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944
p.S63G	HCC-56	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1667
p.S63G	KMS-11	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1667
p.S63G	HUH-6-clone5	liver	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1667
p.S63G	BHY	upper aerodigestive tract	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1667
p.G83S	SNU-1040	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.K75N	NCI-H2347	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	69:73	Mutation blocking ubiquitination signal	0.7222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC42EP4

UniProt ID: Q9H3Q1

Entrez ID: 23580

Protein name: Cdc42 effector protein 4 (Binder of Rho GTPases 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC42EP4 in