DegronMD

Uniprot ID: Q9H3Q1

Source protein: Cdc42 effector protein 4

Source gene: CDC42EP4

Class: DEG_APCC_DBOX_1

Location: 99:107

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7678

ASA_SCORE: 78.4444

COIL: 0.5618

CONS_SCORE: 0.6825

DSS_SCORE: 0.5188

HELIX: 0.4033

FCONS_SCORE: 0.9361

RIG_SCORE: 0.7261

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R107L	TCGA-37-3789	LUSC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	0.7316
p.R107L	TCGA-D3-A2JL	SKCM	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	0.7316
p.R107L	DO26743	LUSC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.7316
p.R107L	DO47278	SKCM	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.7316
p.R94S	TCGA-95-7567	LUAD	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	0.1944
p.R94S	DO25564	LUAD	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.1944
p.S109L	TCGA-A5-A0G2	UCEC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	0.7222
p.S109L	TCGA-MA-AA41	CESC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	0.7222
p.S109L	DO219723	CESC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.7222
p.S109L	DO41235	UCEC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.7222
p.E96G	TCGA-CK-6747	COAD	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	0.25
p.E96G	DO10156	COAD	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.25
p.S91L	TCGA-CN-4739	HNSC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	0.5556
p.S91L	DO14478	HNSC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.5556
p.R97Q	TCGA-PG-A6IB	UCEC	TCGA	QRDMLGSLR	DEG_APCC_DBOX_1	0.2778
p.R97Q	DO52419	UCEC	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.2778
p.A116V	DO227976	COCA	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.0833
p.A116V	DO220878	MELA	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.0833
p.M102I	DO229250	THCA	ICGC	QRDMLGSLR	DEG_APCC_DBOX_1	0.6507
p.R100H	SIDM00958	Chronic Myelogenous Leukemia	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	0.8244
p.R100H	ACH-000920	Leukemia	CCLE	QRDMLGSLR	DEG_APCC_DBOX_1	0.8244
p.M102V	SIDM00656	Burkitt's Lymphoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	0.6097
p.M102V	SIDM00849	Kidney Carcinoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	0.6097
p.M102V	SIDM01107	Melanoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	0.6097
p.M102V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	0.6097
p.M102V	SIDM01173	Rhabdomyosarcoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	0.6097
p.M102V	SIDM00641	Burkitt's Lymphoma	GDSC	QRDMLGSLR	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3Q1	Cdc42 effector protein 4	DEG_APCC_DBOX_1	99:107	QRDMLGSLR	APC,CDC20,FZR1	0.7678	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRDMLGSLR

Degron related mutations and impact score

Drug responses associated with CDC42EP4 mutations

All proteins holding degron of QRDMLGSLR