DegronMD - Q15070(OXA1L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W91C	TCGA-B5-A3FA	UCEC	TCGA	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation altering degron motif	0.7
p.R418L	TCGA-DA-A1I1	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.8428
p.R418W	TCGA-EY-A1H0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.8634
p.W429R	TCGA-P4-A5EB	KIRP	TCGA	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1389
p.P72L	DO14160	HNSC	ICGC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.0556
p.V75I	DO229346	LAML	ICGC	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation rewiring degron network	0.0556
p.V75I	DO229346	LAML	ICGC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.1389
p.V75I	DO230659	LAML	ICGC	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation rewiring degron network	0.0556
p.V75I	DO230659	LAML	ICGC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.1389
p.V75I	DO52365	LUSC	ICGC	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation rewiring degron network	0.0556
p.V75I	DO52365	LUSC	ICGC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.1389
p.A96T	DO228390	LICA	ICGC	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation rewiring degron network	0.2778
p.A96T	DO228390	LICA	ICGC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.1389
p.A74S	DO229041	LICA	ICGC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.1111
p.D416G	DO41638	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.T83A	DO42472	UCEC	ICGC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation altering degron motif	0.7139
p.Q77R	SIDM02030	Colorectal Carcinoma	GDSC	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation rewiring degron network	0.1111
p.Q77R	SIDM02030	Colorectal Carcinoma	GDSC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.1944
p.P416A	SIDM00672	Hepatocellular Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.P416A	SIDM00656	Burkitt's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.P416A	SIDM00654	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.P416A	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.P416A	SIDM00690	Head and Neck Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.P416A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.P416A	SIDM00641	Burkitt's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.P416A	SIDM01752	Pancreatic Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.L100F	SIDM00871	Non-Cancerous	GDSC	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation rewiring degron network	0.1667
p.L100F	SIDM00872	Breast Carcinoma	GDSC	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation rewiring degron network	0.1667
p.R74C	SIDM00217	Colorectal Carcinoma	GDSC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.1111
p.R74C	SNU-1040	large intestine	COSMIC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.1111
p.D413E	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1944
p.D413E	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1944
p.K426T	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2222
p.K426T	NCI-H1793	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2222
p.P418S	ACH-000917	Esophageal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.6752
p.P418S	TE-4	oesophagus	COSMIC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.6752
p.S419N	ACH-000980	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.5958
p.S419N	NCI-H1155	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	418:422	Mutation altering degron motif	0.5958
p.V103I	ACH-001751	Sarcoma	CCLE	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation rewiring degron network	0.0833
p.E77D	OV-90	ovary	COSMIC	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation rewiring degron network	0.1111
p.E77D	OV-90	ovary	COSMIC	VAATPSPT	DEG_SCF_FBW7_1	82:89	Mutation rewiring degron network	0.1944
p.E93D	OV-90	ovary	COSMIC	TPSPTAVPEV	DEG_COP1_1	85:94	Mutation altering degron motif	0.5647

Kaplan plot for OXA1L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OXA1L

UniProt ID: Q15070

Entrez ID: 5018

Protein name: Mitochondrial inner membrane protein OXA1L (Hsa) (OXA1Hs) (Oxidase assembly 1-like protein) (OXA1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OXA1L in