DegronMD

Uniprot ID: Q15070

Source protein: Mitochondrial inner membrane protein OXA1L

Source gene: OXA1L

Class: DEG_COP1_1

Location: 85:94

E3 ligase: COP1

DEGRON score: 0.5931

ASA_SCORE: 76.03

COIL: 0.9155

CONS_SCORE: 0.2306

DSS_SCORE: 0.4675

HELIX: 0.0354

FCONS_SCORE: 0.911

RIG_SCORE: 0.7035

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W91C	TCGA-B5-A3FA	UCEC	TCGA	TPSPTAVPEV	DEG_COP1_1	0.7
p.E93D	OV-90	ovary	COSMIC	TPSPTAVPEV	DEG_COP1_1	0.5647
p.A96T	DO228390	LICA	ICGC	TPSPTAVPEV	DEG_COP1_1	0.2778
p.L100F	SIDM00871	Non-Cancerous	GDSC	TPSPTAVPEV	DEG_COP1_1	0.1667
p.L100F	SIDM00872	Breast Carcinoma	GDSC	TPSPTAVPEV	DEG_COP1_1	0.1667
p.Q77R	SIDM02030	Colorectal Carcinoma	GDSC	TPSPTAVPEV	DEG_COP1_1	0.1111
p.E77D	OV-90	ovary	COSMIC	TPSPTAVPEV	DEG_COP1_1	0.1111
p.V103I	ACH-001751	Sarcoma	CCLE	TPSPTAVPEV	DEG_COP1_1	0.0833
p.V75I	DO229346	LAML	ICGC	TPSPTAVPEV	DEG_COP1_1	0.0556
p.V75I	DO230659	LAML	ICGC	TPSPTAVPEV	DEG_COP1_1	0.0556
p.V75I	DO52365	LUSC	ICGC	TPSPTAVPEV	DEG_COP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15070	Mitochondrial inner membrane protein OXA1L	DEG_COP1_1	85:94	TPSPTAVPEV	COP1	0.5931	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons