DegronMD

Uniprot ID: Q15070

Source protein: Mitochondrial inner membrane protein OXA1L

Source gene: OXA1L

Class: DEG_SCF_FBW7_1

Location: 82:89

E3 ligase: FBXW7

DEGRON score: 0.8718

ASA_SCORE: 79.9625

COIL: 0.937

CONS_SCORE: 0.2291

DSS_SCORE: 0.4491

HELIX: 0.0165

FCONS_SCORE: 0.9077

RIG_SCORE: 0.693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P72L	DO14160	HNSC	ICGC	VAATPSPT	DEG_SCF_FBW7_1	0.0556
p.V75I	DO229346	LAML	ICGC	VAATPSPT	DEG_SCF_FBW7_1	0.1389
p.V75I	DO230659	LAML	ICGC	VAATPSPT	DEG_SCF_FBW7_1	0.1389
p.V75I	DO52365	LUSC	ICGC	VAATPSPT	DEG_SCF_FBW7_1	0.1389
p.A96T	DO228390	LICA	ICGC	VAATPSPT	DEG_SCF_FBW7_1	0.1389
p.A74S	DO229041	LICA	ICGC	VAATPSPT	DEG_SCF_FBW7_1	0.1111
p.T83A	DO42472	UCEC	ICGC	VAATPSPT	DEG_SCF_FBW7_1	0.7139
p.Q77R	SIDM02030	Colorectal Carcinoma	GDSC	VAATPSPT	DEG_SCF_FBW7_1	0.1944
p.R74C	SIDM00217	Colorectal Carcinoma	GDSC	VAATPSPT	DEG_SCF_FBW7_1	0.1111
p.R74C	SNU-1040	large_intestine	COSMIC	VAATPSPT	DEG_SCF_FBW7_1	0.1111
p.E77D	OV-90	ovary	COSMIC	VAATPSPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15070	Mitochondrial inner membrane protein OXA1L	DEG_SCF_FBW7_1	82:89	VAATPSPT	FBXW7	0.8718	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons