DegronMD - O43426(SYNJ1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E997Q	TCGA-22-4601	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.2778
p.P1343L	TCGA-A5-A0G2	UCEC	TCGA	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation altering degron motif	0.7582
p.R1001Q	TCGA-AA-A010	COAD	TCGA	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.1667
p.A987T	TCGA-AP-A051	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.2222
p.E1062D	TCGA-AX-A3FT	UCEC	TCGA	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation altering degron motif	0.6758
p.L1022V	TCGA-BS-A0UF	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.0556
p.S1058I	TCGA-DU-6392	LGG	TCGA	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation altering degron motif	0.7341
p.T1321I	TCGA-EE-A2GO	SKCM	TCGA	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation rewiring degron network	0.3056
p.P1358L	TCGA-EE-A2MS	SKCM	TCGA	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation rewiring degron network	0.1111
p.L1065F	TCGA-EE-A3AG	SKCM	TCGA	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.3056
p.L1065F	TCGA-GU-A767	BLCA	TCGA	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.3056
p.D1049H	TCGA-GV-A6ZA	BLCA	TCGA	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation blocking phosphorylation signal	0.6111
p.E1356Q	TCGA-SY-A9G5	BLCA	TCGA	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation rewiring degron network	0.1667
p.S1073L	TCGA-ZS-A9CF	LIHC	TCGA	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.0833
p.E1317Q	DO51906	BLCA	ICGC	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation rewiring degron network	0.1944
p.L1026F	DO51892	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.1667
p.L1026F	DO37471	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.1667
p.M981I	DO44097	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.0556
p.G1039C	DO5583	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.25
p.R1047Q	DO8842	COAD	ICGC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.1111
p.P1324S	DO8264	COAD	ICGC	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation altering degron motif	0.6752
p.G1059C	DO14250	HNSC	ICGC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation altering degron motif	0.6489
p.P1352T	DO228978	LICA	ICGC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation rewiring degron network	0.2778
p.P1032T	DO229022	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation altering degron motif	0.7031
p.S1034L	DO49722	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation altering degron motif	0.7667
p.S982N	DO22962	LIHC	ICGC	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.0833
p.L1328P	DO30080	OV	ICGC	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation rewiring degron network	0.3056
p.T1040I	DO28190	OV	ICGC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.2222
p.P1050S	DO229459	SKCA	ICGC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.1944
p.P1348L	DO218874	SKCA	ICGC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation altering degron motif	0.7582
p.R1070G	DO37567	SKCM	ICGC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.1667
p.P1319L	DO37567	SKCM	ICGC	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation rewiring degron network	0.25
p.P1350L	DO47281	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation altering degron motif	0.6471
p.P1350S	DO47281	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation altering degron motif	0.6752
p.R1354K	DO37782	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation rewiring degron network	0.2222
p.P1348T	DO48665	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation altering degron motif	0.7031
p.P1065S	DO47309	SKCM	ICGC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.3056
p.S1360F	DO219487	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation rewiring degron network	0.0556
p.E1023D	DO40801	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.0833
p.G1037D	DO42320	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.3056
p.K1337N	DO41746	UCEC	ICGC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation substituting flanking lysine	0.3333
p.K1337N	DO41746	UCEC	ICGC	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation substituting flanking lysine	0.1667
p.S1044F	DO41211	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation blocking phosphorylation signal	0.5556
p.L983V	DO41488	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.1111
p.I1056M	DO43971	UCEC	ICGC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation altering degron motif	0.6507
p.S1058G	SIDM00216	Colorectal Carcinoma	GDSC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation altering degron motif	0.6993
p.S1058G	ACH-000989	Colon/Colorectal Cancer	CCLE	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation altering degron motif	0.6993
p.S1058G	SNU-175	large intestine	COSMIC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation altering degron motif	0.6993
p.V990A	SIDM00845	Burkitt's Lymphoma	GDSC	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.3056
p.V990A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.3056
p.V990A	SIDM00461	Acute Myeloid Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.3056
p.V990A	SIDM01519	Head and Neck Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.3056
p.V990A	ACH-000786	Lymphoma	CCLE	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.3056
p.V990A	ACH-000992	Head and Neck Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.3056
p.A1046V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.0833
p.A1046V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.0556
p.A1046V	ACH-000980	Lung Cancer	CCLE	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.0833
p.A1046V	ACH-000980	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.0556
p.A1046V	NCI-H1155	lung	COSMIC	TISEGPVPSL	DEG_COP1_1	1055:1064	Mutation rewiring degron network	0.0833
p.A1046V	NCI-H1155	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.0556
p.V1345I	SIDM01409	Bladder Carcinoma	GDSC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation altering degron motif	0.7076
p.E1346Q	SIDM01520	Oral Cavity Carcinoma	GDSC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation altering degron motif	0.6744
p.Q1316P	ACH-000153	Lung Cancer	CCLE	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation rewiring degron network	0.1667
p.Q1316P	ACH-000252	Colon/Colorectal Cancer	CCLE	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation rewiring degron network	0.1667
p.Q1316P	ACH-000491	Colon/Colorectal Cancer	CCLE	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation rewiring degron network	0.1667
p.E1320K	ACH-000900	Lung Cancer	CCLE	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation rewiring degron network	0.2778
p.E1320K	NCI-H23	lung	COSMIC	IDPFED	LIG_APCC_ABBA_1	1322:1327	Mutation rewiring degron network	0.2778
p.A1002V	NCI-H1155	lung	COSMIC	PSSTS	DEG_SPOP_SBC_1	991:995	Mutation rewiring degron network	0.1389
p.S1031F	SW684	soft tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation rewiring degron network	0.3056
p.I1350S	JVM-3	haematopoietic and lymphoid tissue	COSMIC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation altering degron motif	0.7341
p.P1346T	SNU-81	large intestine	COSMIC	SVQTSPVPTP	DEG_COP1_1	1341:1350	Mutation altering degron motif	0.5919
p.S1036F	SW684	soft tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	1032:1036	Mutation altering degron motif	0.7982

Kaplan plot for SYNJ1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYNJ1

UniProt ID: O43426

Entrez ID: 8867

Protein name: Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYNJ1 in