DegronMD

Uniprot ID: O43426

Source protein: Synaptojanin-1

Source gene: SYNJ1

Class: DEG_COP1_1

Location: 1341:1350

E3 ligase: COP1

DEGRON score: 0.9952

ASA_SCORE: 95.33

COIL: 0.9432

CONS_SCORE: 0.3158

DSS_SCORE: 0.5025

HELIX: 0.0179

FCONS_SCORE: 1.0105

RIG_SCORE: 0.6824

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1343L	TCGA-A5-A0G2	UCEC	TCGA	SVQTSPVPTP	DEG_COP1_1	0.7582
p.P1358L	TCGA-EE-A2MS	SKCM	TCGA	SVQTSPVPTP	DEG_COP1_1	0.1111
p.E1356Q	TCGA-SY-A9G5	BLCA	TCGA	SVQTSPVPTP	DEG_COP1_1	0.1667
p.P1352T	DO228978	LICA	ICGC	SVQTSPVPTP	DEG_COP1_1	0.2778
p.P1348L	DO218874	SKCA	ICGC	SVQTSPVPTP	DEG_COP1_1	0.7582
p.P1350L	DO47281	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	0.6471
p.P1350S	DO47281	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	0.6752
p.R1354K	DO37782	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	0.2222
p.P1348T	DO48665	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	0.7031
p.S1360F	DO219487	SKCM	ICGC	SVQTSPVPTP	DEG_COP1_1	0.0556
p.K1337N	DO41746	UCEC	ICGC	SVQTSPVPTP	DEG_COP1_1	0.3333
p.V1345I	SIDM01409	Bladder Carcinoma	GDSC	SVQTSPVPTP	DEG_COP1_1	0.7076
p.E1346Q	SIDM01520	Oral Cavity Carcinoma	GDSC	SVQTSPVPTP	DEG_COP1_1	0.6744
p.I1350S	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	SVQTSPVPTP	DEG_COP1_1	0.7341
p.P1346T	SNU-81	large_intestine	COSMIC	SVQTSPVPTP	DEG_COP1_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43426	Synaptojanin-1	DEG_COP1_1	1341:1350	SVQTSPVPTP	COP1	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons