DegronMD

Uniprot ID: O43426

Source protein: Synaptojanin-1

Source gene: SYNJ1

Class: LIG_APCC_ABBA_1

Location: 1322:1327

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7548

ASA_SCORE: 67.0667

COIL: 0.6267

CONS_SCORE: 0.316

DSS_SCORE: 0.3695

HELIX: 0.347

FCONS_SCORE: 1.0071

RIG_SCORE: 0.8007

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1321I	TCGA-EE-A2GO	SKCM	TCGA	IDPFED	LIG_APCC_ABBA_1	0.3056
p.E1317Q	DO51906	BLCA	ICGC	IDPFED	LIG_APCC_ABBA_1	0.1944
p.P1324S	DO8264	COAD	ICGC	IDPFED	LIG_APCC_ABBA_1	0.6752
p.L1328P	DO30080	OV	ICGC	IDPFED	LIG_APCC_ABBA_1	0.3056
p.P1319L	DO37567	SKCM	ICGC	IDPFED	LIG_APCC_ABBA_1	0.25
p.K1337N	DO41746	UCEC	ICGC	IDPFED	LIG_APCC_ABBA_1	0.1667
p.Q1316P	ACH-000153	Lung Cancer	CCLE	IDPFED	LIG_APCC_ABBA_1	0.1667
p.Q1316P	ACH-000252	Colon/Colorectal Cancer	CCLE	IDPFED	LIG_APCC_ABBA_1	0.1667
p.Q1316P	ACH-000491	Colon/Colorectal Cancer	CCLE	IDPFED	LIG_APCC_ABBA_1	0.1667
p.E1320K	ACH-000900	Lung Cancer	CCLE	IDPFED	LIG_APCC_ABBA_1	0.2778
p.E1320K	NCI-H23	lung	COSMIC	IDPFED	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43426	Synaptojanin-1	LIG_APCC_ABBA_1	1322:1327	IDPFED	APC,CDC20,FZR1	0.7548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons