DegronMD

Uniprot ID: O43426

Source protein: Synaptojanin-1

Source gene: SYNJ1

Class: DEG_COP1_1

Location: 1055:1064

E3 ligase: COP1

DEGRON score: 0.979

ASA_SCORE: 87.99

COIL: 0.9551

CONS_SCORE: 0.3163

DSS_SCORE: 0.7572

HELIX: 0.018

FCONS_SCORE: 0.979

RIG_SCORE: 0.5811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1062D	TCGA-AX-A3FT	UCEC	TCGA	TISEGPVPSL	DEG_COP1_1	0.6758
p.S1058I	TCGA-DU-6392	LGG	TCGA	TISEGPVPSL	DEG_COP1_1	0.7341
p.L1065F	TCGA-EE-A3AG	SKCM	TCGA	TISEGPVPSL	DEG_COP1_1	0.3056
p.L1065F	TCGA-GU-A767	BLCA	TCGA	TISEGPVPSL	DEG_COP1_1	0.3056
p.D1049H	TCGA-GV-A6ZA	BLCA	TCGA	TISEGPVPSL	DEG_COP1_1	0.6111
p.S1073L	TCGA-ZS-A9CF	LIHC	TCGA	TISEGPVPSL	DEG_COP1_1	0.0833
p.R1047Q	DO8842	COAD	ICGC	TISEGPVPSL	DEG_COP1_1	0.1111
p.G1059C	DO14250	HNSC	ICGC	TISEGPVPSL	DEG_COP1_1	0.6489
p.P1050S	DO229459	SKCA	ICGC	TISEGPVPSL	DEG_COP1_1	0.1944
p.R1070G	DO37567	SKCM	ICGC	TISEGPVPSL	DEG_COP1_1	0.1667
p.P1065S	DO47309	SKCM	ICGC	TISEGPVPSL	DEG_COP1_1	0.3056
p.I1056M	DO43971	UCEC	ICGC	TISEGPVPSL	DEG_COP1_1	0.6507
p.S1058G	SIDM00216	Colorectal Carcinoma	GDSC	TISEGPVPSL	DEG_COP1_1	0.6993
p.S1058G	ACH-000989	Colon/Colorectal Cancer	CCLE	TISEGPVPSL	DEG_COP1_1	0.6993
p.S1058G	SNU-175	large_intestine	COSMIC	TISEGPVPSL	DEG_COP1_1	0.6993
p.A1046V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	TISEGPVPSL	DEG_COP1_1	0.0833
p.A1046V	ACH-000980	Lung Cancer	CCLE	TISEGPVPSL	DEG_COP1_1	0.0833
p.A1046V	NCI-H1155	lung	COSMIC	TISEGPVPSL	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43426	Synaptojanin-1	DEG_COP1_1	1055:1064	TISEGPVPSL	COP1	0.979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons