DegronMD - Q8HWS3(RFX6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R866G	TCGA-43-2576	LUSC	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866G	DO27005	LUSC	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R829H	TCGA-A5-A0G2	UCEC	TCGA	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2778
p.R829H	DO41235	UCEC	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2778
p.G638S	TCGA-A8-A08X	BRCA	TCGA	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.2778
p.G638S	DO2347	BRCA	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.2778
p.S646Y	TCGA-AA-3510	COAD	TCGA	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation altering degron motif	0.712
p.S646Y	DO7783	COAD	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation altering degron motif	0.712
p.R866Q	TCGA-AA-A00N	COAD	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	TCGA-AG-A002	READ	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	TCGA-B5-A11N	UCEC	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	TCGA-EI-6917	READ	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	DO9876	COAD	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	DO36881	READ	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	DO229459	SKCA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	DO41458	UCEC	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	SIDM00503	Gastric Carcinoma	GDSC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	ACH-000633	Gastric Cancer	CCLE	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.R866Q	FU97	stomach	COSMIC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.C885R	TCGA-AR-A1AI	BRCA	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1944
p.C885R	TCGA-AR-A1AI	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.C885R	TCGA-B5-A3FA	UCEC	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1944
p.C885R	TCGA-B5-A3FA	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.C885R	DO4689	BRCA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1944
p.C885R	DO4689	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.C885R	DO231977	LICA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1944
p.C885R	DO231977	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.C885R	DO52402	UCEC	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1944
p.C885R	DO52402	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.2778
p.L633I	TCGA-AX-A2HC	UCEC	TCGA	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.1389
p.L633I	DO41572	UCEC	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.1389
p.V706M	TCGA-AZ-6601	COAD	TCGA	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1944
p.V706M	DO8119	COAD	ICGC	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1944
p.P840L	TCGA-CV-7255	HNSC	TCGA	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2222
p.P840L	DO14718	HNSC	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2222
p.H639N	TCGA-CX-7086	HNSC	TCGA	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.H639N	DO15046	HNSC	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.H639N	SIDM00392	Melanoma	GDSC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.H639N	ACH-000810	Skin Cancer	CCLE	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.H639N	SK-MEL-30	skin	COSMIC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.G888E	TCGA-D3-A1Q7	SKCM	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.G888E	TCGA-D3-A1Q7	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.G888E	TCGA-EB-A431	SKCM	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.G888E	TCGA-EB-A431	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.G888E	DO37671	SKCM	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.G888E	DO37671	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.G888E	DO37981	SKCM	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.1111
p.G888E	DO37981	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1944
p.P833L	TCGA-D3-A3ML	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation altering degron motif	0.6471
p.P833L	DO47413	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation altering degron motif	0.6471
p.D839N	TCGA-D3-A8GI	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.25
p.D839N	DO50284	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.25
p.D839N	SIDM00080	Melanoma	GDSC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.25
p.D839N	ACH-000730	Skin Cancer	CCLE	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.25
p.D839N	SK-MEL-5	skin	COSMIC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.25
p.P879S	TCGA-D9-A3Z4	SKCM	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation altering degron motif	0.5641
p.P879S	TCGA-D9-A3Z4	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.6752
p.P879S	DO37623	SKCM	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation altering degron motif	0.5641
p.P879S	DO37623	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.6752
p.S646P	TCGA-DI-A1BU	UCEC	TCGA	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation altering degron motif	0.6752
p.S646P	DO42023	UCEC	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation altering degron motif	0.6752
p.S890F	TCGA-EE-A29E	SKCM	TCGA	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.0556
p.S890F	TCGA-EE-A29E	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1389
p.S890F	DO37831	SKCM	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.0556
p.S890F	DO37831	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1389
p.P644S	TCGA-EE-A29V	SKCM	TCGA	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation altering degron motif	0.5641
p.P644S	DO38006	SKCM	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation altering degron motif	0.5641
p.R829C	TCGA-EE-A2GS	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2778
p.R829C	TCGA-WE-A8ZX	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2778
p.R829C	DO37465	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2778
p.R829C	DO51291	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2778
p.H720Y	TCGA-ER-A19F	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1944
p.H720Y	DO37679	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1944
p.H720Y	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1944
p.H720Y	ACH-000951	Lung Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1944
p.H720Y	NCI-H2342	lung	COSMIC	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1944
p.S881F	TCGA-FR-A3YN	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7982
p.S881F	DO229177	LMS	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7982
p.S881F	DO38111	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7982
p.H838Y	TCGA-FS-A1YY	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2778
p.H838Y	DO37415	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.2778
p.D846Y	TCGA-L5-A4OE	ESCA	TCGA	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.0556
p.S823F	TCGA-L5-A8NQ	ESCA	TCGA	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.1111
p.S823F	DO220885	MELA	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.1111
p.R708M	TCGA-OL-A6VO	BRCA	TCGA	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.25
p.R708M	DO51213	BRCA	ICGC	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.25
p.S715L	TCGA-W3-A824	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation altering degron motif	0.7667
p.S715L	DO51271	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation altering degron motif	0.7667
p.E632K	TCGA-WE-A8K5	SKCM	TCGA	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.1111
p.E632K	DO51282	SKCM	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.1111
p.L717F	TCGA-YD-A9TA	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.2778
p.L717F	DO219503	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.2778
p.S890P	DO48413	BLCA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.0556
p.S890P	DO48413	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1389
p.D839V	DO50437	ESAD	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.25
p.M631T	DO234288	ESAD	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.0833
p.H639Y	DO48292	ESCA	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.A637S	DO228330	LICA	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.25
p.L874F	DO228971	LICA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation altering degron motif	0.6981
p.G638V	DO229015	LICA	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.2778
p.G638V	SIDM01118	Small Cell Lung Carcinoma	GDSC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.2778
p.G638V	ACH-002175	Lung Cancer	CCLE	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.2778
p.G638V	NCI-H740	lung	COSMIC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.2778
p.S882L	DO229058	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7667
p.V655I	DO221125	MALY	ICGC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.0833
p.S883F	DO222868	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation altering degron motif	0.7982
p.L841P	DO218863	SKCA	ICGC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.1944
p.Q875K	SIDM00672	Hepatocellular Carcinoma	GDSC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation altering degron motif	0.5833
p.Q875K	ACH-000625	Liver Cancer	CCLE	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation altering degron motif	0.5833
p.Q875K	Hep_3B2_1-7	NS	COSMIC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation altering degron motif	0.5833
p.P647S	SIDM00973	Melanoma	GDSC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.P647S	ACH-000827	Skin Cancer	CCLE	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.P647S	WM793B	skin	COSMIC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.S872F	SIDM01175	Other Sarcomas	GDSC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.2778
p.S872F	SIDM01175	Other Sarcomas	GDSC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1389
p.S872F	ACH-002309	Sarcoma	CCLE	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.2778
p.S872F	ACH-002309	Sarcoma	CCLE	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1389
p.S872F	SW684	soft tissue	COSMIC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.2778
p.S872F	SW684	soft tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.1389
p.S830P	SIDM00789	Colorectal Carcinoma	GDSC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.3056
p.S830P	ACH-000997	Colon/Colorectal Cancer	CCLE	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.3056
p.S830P	ACH-001061	Colon/Colorectal Cancer	CCLE	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.3056
p.S830P	HCT-15	large intestine	COSMIC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.3056
p.V822I	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.0833
p.V822I	ACH-000061	Lymphoma	CCLE	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.0833
p.V822I	HH	haematopoietic and lymphoid tissue	COSMIC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.0833
p.H821Q	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.0556
p.H821Q	ACH-000853	Lung Cancer	CCLE	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.0556
p.H821Q	NCI-H661	lung	COSMIC	LPPYSD	LIG_APCC_ABBA_1	831:836	Mutation rewiring degron network	0.0556
p.L870P	SIDM01060	Melanoma	GDSC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.2222
p.L870P	SIDM01060	Melanoma	GDSC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0833
p.L870P	ACH-000882	Skin Cancer	CCLE	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.2222
p.L870P	ACH-000882	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0833
p.L870P	IGR-1	skin	COSMIC	LQTPIPS	DEG_SCF_FBW7_1	874:880	Mutation rewiring degron network	0.2222
p.L870P	IGR-1	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	879:883	Mutation rewiring degron network	0.0833
p.H639L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.H639L	ACH-002222	Leukemia	CCLE	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.H639L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LMTPPIS	DEG_SCF_FBW7_1	640:646	Mutation rewiring degron network	0.3056
p.E723K	SIDM01608	Endometrial Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1111
p.E723K	ACH-000990	Endometrial/Uterine Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFX6

UniProt ID: Q8HWS3

Entrez ID: 222546

Protein name: DNA-binding protein RFX6 (Regulatory factor X 6) (Regulatory factor X domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFX6 in