DegronMD

Uniprot ID: Q8HWS3

Source protein: DNA-binding protein RFX6

Source gene: RFX6

Class: LIG_APCC_ABBA_1

Location: 831:836

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9682

ASA_SCORE: 75.85

COIL: 0.8338

CONS_SCORE: 0.2461

DSS_SCORE: 0.3229

HELIX: 0.0522

FCONS_SCORE: 0.8101

RIG_SCORE: 0.6921

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R829H	TCGA-A5-A0G2	UCEC	TCGA	LPPYSD	LIG_APCC_ABBA_1	0.2778
p.R829H	DO41235	UCEC	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.2778
p.P840L	TCGA-CV-7255	HNSC	TCGA	LPPYSD	LIG_APCC_ABBA_1	0.2222
p.P840L	DO14718	HNSC	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.2222
p.P833L	TCGA-D3-A3ML	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	0.6471
p.P833L	DO47413	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.6471
p.D839N	TCGA-D3-A8GI	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	0.25
p.D839N	DO50284	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.25
p.D839N	SIDM00080	Melanoma	GDSC	LPPYSD	LIG_APCC_ABBA_1	0.25
p.D839N	ACH-000730	Skin Cancer	CCLE	LPPYSD	LIG_APCC_ABBA_1	0.25
p.D839N	SK-MEL-5	skin	COSMIC	LPPYSD	LIG_APCC_ABBA_1	0.25
p.R829C	TCGA-EE-A2GS	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	0.2778
p.R829C	TCGA-WE-A8ZX	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	0.2778
p.R829C	DO37465	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.2778
p.R829C	DO51291	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.2778
p.H838Y	TCGA-FS-A1YY	SKCM	TCGA	LPPYSD	LIG_APCC_ABBA_1	0.2778
p.H838Y	DO37415	SKCM	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.2778
p.D846Y	TCGA-L5-A4OE	ESCA	TCGA	LPPYSD	LIG_APCC_ABBA_1	0.0556
p.S823F	TCGA-L5-A8NQ	ESCA	TCGA	LPPYSD	LIG_APCC_ABBA_1	0.1111
p.S823F	DO220885	MELA	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.1111
p.D839V	DO50437	ESAD	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.25
p.L841P	DO218863	SKCA	ICGC	LPPYSD	LIG_APCC_ABBA_1	0.1944
p.S830P	SIDM00789	Colorectal Carcinoma	GDSC	LPPYSD	LIG_APCC_ABBA_1	0.3056
p.S830P	ACH-000997	Colon/Colorectal Cancer	CCLE	LPPYSD	LIG_APCC_ABBA_1	0.3056
p.S830P	ACH-001061	Colon/Colorectal Cancer	CCLE	LPPYSD	LIG_APCC_ABBA_1	0.3056
p.S830P	HCT-15	large_intestine	COSMIC	LPPYSD	LIG_APCC_ABBA_1	0.3056
p.V822I	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	LPPYSD	LIG_APCC_ABBA_1	0.0833
p.V822I	ACH-000061	Lymphoma	CCLE	LPPYSD	LIG_APCC_ABBA_1	0.0833
p.V822I	HH	haematopoietic_and_lymphoid_tissue	COSMIC	LPPYSD	LIG_APCC_ABBA_1	0.0833
p.H821Q	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	LPPYSD	LIG_APCC_ABBA_1	0.0556
p.H821Q	ACH-000853	Lung Cancer	CCLE	LPPYSD	LIG_APCC_ABBA_1	0.0556
p.H821Q	NCI-H661	lung	COSMIC	LPPYSD	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPPYSD

Degron related mutations and impact score

Drug responses associated with RFX6 mutations

All proteins holding degron of LPPYSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8HWS3	DNA-binding protein RFX6	LIG_APCC_ABBA_1	831:836	LPPYSD	APC,CDC20,FZR1	0.9682	More...