DegronMD

Uniprot ID: Q8HWS3

Source protein: DNA-binding protein RFX6

Source gene: RFX6

Class: DEG_SCF_FBW7_1

Location: 640:646

E3 ligase: FBXW7

DEGRON score: 0.9524

ASA_SCORE: 68.3143

COIL: 0.9139

CONS_SCORE: 0.3159

DSS_SCORE: 0.4999

HELIX: 0.0311

FCONS_SCORE: 1.072

RIG_SCORE: 0.6915

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G638S	TCGA-A8-A08X	BRCA	TCGA	LMTPPIS	DEG_SCF_FBW7_1	0.2778
p.G638S	DO2347	BRCA	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.2778
p.S646Y	TCGA-AA-3510	COAD	TCGA	LMTPPIS	DEG_SCF_FBW7_1	0.712
p.S646Y	DO7783	COAD	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.712
p.L633I	TCGA-AX-A2HC	UCEC	TCGA	LMTPPIS	DEG_SCF_FBW7_1	0.1389
p.L633I	DO41572	UCEC	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.1389
p.H639N	TCGA-CX-7086	HNSC	TCGA	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.H639N	DO15046	HNSC	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.H639N	SIDM00392	Melanoma	GDSC	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.H639N	ACH-000810	Skin Cancer	CCLE	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.H639N	SK-MEL-30	skin	COSMIC	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.S646P	TCGA-DI-A1BU	UCEC	TCGA	LMTPPIS	DEG_SCF_FBW7_1	0.6752
p.S646P	DO42023	UCEC	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.6752
p.P644S	TCGA-EE-A29V	SKCM	TCGA	LMTPPIS	DEG_SCF_FBW7_1	0.5641
p.P644S	DO38006	SKCM	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.5641
p.E632K	TCGA-WE-A8K5	SKCM	TCGA	LMTPPIS	DEG_SCF_FBW7_1	0.1111
p.E632K	DO51282	SKCM	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.1111
p.M631T	DO234288	ESAD	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.0833
p.H639Y	DO48292	ESCA	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.A637S	DO228330	LICA	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.25
p.G638V	DO229015	LICA	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.2778
p.G638V	SIDM01118	Small Cell Lung Carcinoma	GDSC	LMTPPIS	DEG_SCF_FBW7_1	0.2778
p.G638V	ACH-002175	Lung Cancer	CCLE	LMTPPIS	DEG_SCF_FBW7_1	0.2778
p.G638V	NCI-H740	lung	COSMIC	LMTPPIS	DEG_SCF_FBW7_1	0.2778
p.V655I	DO221125	MALY	ICGC	LMTPPIS	DEG_SCF_FBW7_1	0.0833
p.P647S	SIDM00973	Melanoma	GDSC	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.P647S	ACH-000827	Skin Cancer	CCLE	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.P647S	WM793B	skin	COSMIC	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.H639L	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.H639L	ACH-002222	Leukemia	CCLE	LMTPPIS	DEG_SCF_FBW7_1	0.3056
p.H639L	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LMTPPIS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LMTPPIS

Degron related mutations and impact score

Drug responses associated with RFX6 mutations

All proteins holding degron of LMTPPIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8HWS3	DNA-binding protein RFX6	DEG_SCF_FBW7_1	640:646	LMTPPIS	FBXW7	0.9524	More...