DegronMD

Uniprot ID: Q8HWS3

Source protein: DNA-binding protein RFX6

Source gene: RFX6

Class: DEG_SCF_FBW7_1

Location: 874:880

E3 ligase: FBXW7

DEGRON score: 0.9478

ASA_SCORE: 84.2571

COIL: 0.9136

CONS_SCORE: 0.2569

DSS_SCORE: 0.4508

HELIX: 0.0504

FCONS_SCORE: 1.0539

RIG_SCORE: 0.6858

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R866G	TCGA-43-2576	LUSC	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866G	DO27005	LUSC	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	TCGA-AA-A00N	COAD	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	TCGA-AG-A002	READ	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	TCGA-B5-A11N	UCEC	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	TCGA-EI-6917	READ	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	DO9876	COAD	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	DO36881	READ	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	DO229459	SKCA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	DO41458	UCEC	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	SIDM00503	Gastric Carcinoma	GDSC	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	ACH-000633	Gastric Cancer	CCLE	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.R866Q	FU97	stomach	COSMIC	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.C885R	TCGA-AR-A1AI	BRCA	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.1944
p.C885R	TCGA-B5-A3FA	UCEC	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.1944
p.C885R	DO4689	BRCA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1944
p.C885R	DO231977	LICA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1944
p.C885R	DO52402	UCEC	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1944
p.G888E	TCGA-D3-A1Q7	SKCM	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.G888E	TCGA-EB-A431	SKCM	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.G888E	DO37671	SKCM	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.G888E	DO37981	SKCM	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.1111
p.P879S	TCGA-D9-A3Z4	SKCM	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.5641
p.P879S	DO37623	SKCM	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.5641
p.S890F	TCGA-EE-A29E	SKCM	TCGA	LQTPIPS	DEG_SCF_FBW7_1	0.0556
p.S890F	DO37831	SKCM	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.0556
p.S890P	DO48413	BLCA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.0556
p.L874F	DO228971	LICA	ICGC	LQTPIPS	DEG_SCF_FBW7_1	0.6981
p.Q875K	SIDM00672	Hepatocellular Carcinoma	GDSC	LQTPIPS	DEG_SCF_FBW7_1	0.5833
p.Q875K	ACH-000625	Liver Cancer	CCLE	LQTPIPS	DEG_SCF_FBW7_1	0.5833
p.Q875K	Hep_3B2_1-7	NS	COSMIC	LQTPIPS	DEG_SCF_FBW7_1	0.5833
p.S872F	SIDM01175	Other Sarcomas	GDSC	LQTPIPS	DEG_SCF_FBW7_1	0.2778
p.S872F	ACH-002309	Sarcoma	CCLE	LQTPIPS	DEG_SCF_FBW7_1	0.2778
p.S872F	SW684	soft_tissue	COSMIC	LQTPIPS	DEG_SCF_FBW7_1	0.2778
p.L870P	SIDM01060	Melanoma	GDSC	LQTPIPS	DEG_SCF_FBW7_1	0.2222
p.L870P	ACH-000882	Skin Cancer	CCLE	LQTPIPS	DEG_SCF_FBW7_1	0.2222
p.L870P	IGR-1	skin	COSMIC	LQTPIPS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQTPIPS

Degron related mutations and impact score

Drug responses associated with RFX6 mutations

All proteins holding degron of LQTPIPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8HWS3	DNA-binding protein RFX6	DEG_SCF_FBW7_1	874:880	LQTPIPS	FBXW7	0.9478	More...