DegronMD

Uniprot ID: Q8HWS3

Source protein: DNA-binding protein RFX6

Source gene: RFX6

Class: DEG_SPOP_SBC_1

Location: 711:715

E3 ligase: SPOP

DEGRON score: 0.9944

ASA_SCORE: 72.72

COIL: 0.9104

CONS_SCORE: 0.3377

DSS_SCORE: 0.4607

HELIX: 0.0368

FCONS_SCORE: 1.1609

RIG_SCORE: 0.6235

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V706M	TCGA-AZ-6601	COAD	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1944
p.V706M	DO8119	COAD	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.H720Y	TCGA-ER-A19F	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.1944
p.H720Y	DO37679	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.H720Y	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.H720Y	ACH-000951	Lung Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	0.1944
p.H720Y	NCI-H2342	lung	COSMIC	PHSTS	DEG_SPOP_SBC_1	0.1944
p.R708M	TCGA-OL-A6VO	BRCA	TCGA	PHSTS	DEG_SPOP_SBC_1	0.25
p.R708M	DO51213	BRCA	ICGC	PHSTS	DEG_SPOP_SBC_1	0.25
p.S715L	TCGA-W3-A824	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.7667
p.S715L	DO51271	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.7667
p.L717F	TCGA-YD-A9TA	SKCM	TCGA	PHSTS	DEG_SPOP_SBC_1	0.2778
p.L717F	DO219503	SKCM	ICGC	PHSTS	DEG_SPOP_SBC_1	0.2778
p.E723K	SIDM01608	Endometrial Carcinoma	GDSC	PHSTS	DEG_SPOP_SBC_1	0.1111
p.E723K	ACH-000990	Endometrial/Uterine Cancer	CCLE	PHSTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2975:2979	PHSTS	SPOP	0.9883	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	379:383	PHSTS	SPOP	0.8054	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	874:878	PHSTS	SPOP	0.9468	More...
Q8HWS3	DNA-binding protein RFX6	DEG_SPOP_SBC_1	711:715	PHSTS	SPOP	0.9944	More...
Q8NG27	E3 ubiquitin-protein ligase Praja-1	DEG_SPOP_SBC_1	284:288	PHSTS	SPOP	0.7228	More...
Q9P2P5	E3 ubiquitin-protein ligase HECW2	DEG_SPOP_SBC_1	905:909	PHSTS	SPOP	0.9068	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons