DegronMD - Q8NI27(THOC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R555L	TCGA-49-AARE	LUAD	TCGA	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.2778
p.K1218I	TCGA-A4-8311	KIRP	TCGA	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation substituting flanking lysine	0.2778
p.K1218I	DO44523	KIRP	ICGC	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation substituting flanking lysine	0.2778
p.D1368G	TCGA-AJ-A3EK	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1389
p.D1368G	DO41584	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1389
p.S1222I	TCGA-AP-A1DV	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.5
p.S1222I	DO43186	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.5
p.M1373T	TCGA-AX-A2HD	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.2778
p.M1373T	DO42608	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.2778
p.R555C	TCGA-AX-A2HJ	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.2778
p.S1219L	TCGA-BS-A0UV	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219L	TCGA-WE-A8ZT	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219L	DO51290	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219L	DO42793	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219L	SIDM00105	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219L	ACH-000001	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.5833
p.S1219L	OVCAR-3	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.5833
p.S1388T	TCGA-D3-A8GR	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation blocking phosphorylation signal	0.5278
p.S1388T	DO51247	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation blocking phosphorylation signal	0.5278
p.S1388Y	TCGA-E6-A1LX	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation blocking phosphorylation signal	0.5278
p.S1388Y	DO41020	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation blocking phosphorylation signal	0.5278
p.P1249L	TCGA-EB-A5UN	SKCM	TCGA	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.3056
p.P1249L	DO47267	SKCM	ICGC	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.3056
p.P1249S	TCGA-EB-A5UN	SKCM	TCGA	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.3056
p.P1249S	DO47267	SKCM	ICGC	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.3056
p.S1217F	TCGA-EE-A2M5	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.6389
p.S1217F	DO37425	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.6389
p.P1386Q	TCGA-EE-A3AA	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1389
p.P1386Q	DO37571	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1389
p.I552M	TCGA-EK-A3GK	CESC	TCGA	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.1944
p.G1251E	TCGA-ER-A194	SKCM	TCGA	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.25
p.G1251E	DO47646	SKCM	ICGC	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.25
p.G1382R	TCGA-FI-A2D0	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.25
p.G1382R	DO43891	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.25
p.S1375P	TCGA-HU-A4GU	STAD	TCGA	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation altering degron motif	0.5641
p.S1375P	DO47849	STAD	ICGC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation altering degron motif	0.5641
p.L553Q	DO1118	BRCA	ICGC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.2222
p.Q1235H	DO223157	ESCA	ICGC	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.0833
p.I563V	DO14926	HNSC	ICGC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.2778
p.I563V	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.2778
p.L561M	DO229026	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation altering degron motif	0.711
p.P1249H	DO229031	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.3056
p.T1248K	DO229031	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation altering degron motif	0.7306
p.E1372K	DO220857	MELA	ICGC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.25
p.A550V	DO41871	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation substituting flanking lysine	0.25
p.L564F	DO52426	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation blocking phosphorylation signal	0.6944
p.A555V	DO43971	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.2778
p.P563S	SIDM00084	Glioblastoma	GDSC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.2778
p.P563S	ACH-000376	Brain Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.2778
p.P563S	SF295	central nervous system	COSMIC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation rewiring degron network	0.2778
p.I1369V	SIDM00845	Burkitt's Lymphoma	GDSC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1667
p.I1369V	SIDM00461	Acute Myeloid Leukemia	GDSC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1667
p.I1369V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1667
p.I1369V	SIDM01519	Head and Neck Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1667
p.I1369V	ACH-000786	Lymphoma	CCLE	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1667
p.I1369V	ACH-000992	Head and Neck Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1667
p.I1369V	ACH-001067	Brain Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1667
p.G1389A	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.0556
p.G1389A	ACH-000893	Lung Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.0556
p.G1389A	NCI-H1651	lung	COSMIC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.0556
p.K1380E	SIDM00518	Mesothelioma	GDSC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.3056
p.K1380E	ACH-002136	Lung Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.3056
p.K1380E	H290	pleura	COSMIC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.3056
p.V1387L	SIDM00936	Bladder Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1111
p.V1387L	ACH-000142	Bladder Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1111
p.V1387L	CAL-29	urinary tract	COSMIC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1111
p.V561M	ACH-000299	Leukemia	CCLE	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation altering degron motif	0.6097
p.P1249R	ACH-000524	Ovarian Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.3056
p.I1213M	ACH-001608	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation rewiring degron network	0.3056
p.S1217Y	ACH-002021	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1208:1212	Mutation blocking phosphorylation signal	0.6389
p.P1386S	ACH-002349	Non-Cancerous	CCLE	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation rewiring degron network	0.1389
p.E1235K	NCI-H835	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation rewiring degron network	0.0833
p.E1245D	CL-11	large intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	1244:1248	Mutation altering degron motif	0.6758
p.R1375S	HT-1197	urinary tract	COSMIC	SKENV	DEG_APCC_KENBOX_2	1375:1379	Mutation altering degron motif	0.7427
p.A550T	CW-2	large intestine	COSMIC	TKENV	DEG_APCC_KENBOX_2	557:561	Mutation substituting flanking lysine	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THOC2

UniProt ID: Q8NI27

Entrez ID: 57187

Protein name: THO complex subunit 2 (Tho2) (hTREX120)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THOC2 in