DegronMD

Uniprot ID: Q8NI27

Source protein: THO complex subunit 2

Source gene: THOC2

Class: DEG_APCC_KENBOX_2

Location: 1375:1379

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5524

ASA_SCORE: 99.14

COIL: 0.656

CONS_SCORE: 0.2483

DSS_SCORE: 0.6832

HELIX: 0.3324

FCONS_SCORE: 0.906

RIG_SCORE: 0.6175

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1368G	TCGA-AJ-A3EK	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	0.1389
p.D1368G	DO41584	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1389
p.M1373T	TCGA-AX-A2HD	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	0.2778
p.M1373T	DO42608	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	0.2778
p.S1388T	TCGA-D3-A8GR	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	0.5278
p.S1388T	DO51247	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	0.5278
p.S1388Y	TCGA-E6-A1LX	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	0.5278
p.S1388Y	DO41020	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	0.5278
p.P1386Q	TCGA-EE-A3AA	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	0.1389
p.P1386Q	DO37571	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1389
p.G1382R	TCGA-FI-A2D0	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	0.25
p.G1382R	DO43891	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	0.25
p.S1375P	TCGA-HU-A4GU	STAD	TCGA	SKENV	DEG_APCC_KENBOX_2	0.5641
p.S1375P	DO47849	STAD	ICGC	SKENV	DEG_APCC_KENBOX_2	0.5641
p.E1372K	DO220857	MELA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.25
p.I1369V	SIDM00845	Burkitt's Lymphoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1667
p.I1369V	SIDM00461	Acute Myeloid Leukemia	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1667
p.I1369V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1667
p.I1369V	SIDM01519	Head and Neck Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1667
p.I1369V	ACH-000786	Lymphoma	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1667
p.I1369V	ACH-000992	Head and Neck Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1667
p.I1369V	ACH-001067	Brain Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1667
p.G1389A	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.0556
p.G1389A	ACH-000893	Lung Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.0556
p.G1389A	NCI-H1651	lung	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.0556
p.K1380E	SIDM00518	Mesothelioma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.3056
p.K1380E	ACH-002136	Lung Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.3056
p.K1380E	H290	pleura	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.3056
p.V1387L	SIDM00936	Bladder Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1111
p.V1387L	ACH-000142	Bladder Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1111
p.V1387L	CAL-29	urinary_tract	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.1111
p.P1386S	ACH-002349	Non-Cancerous	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1389
p.R1375S	HT-1197	urinary_tract	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_KENBOX_2	25:29	SKENV	APC,CDC20,FZR1	0.997	More...
Q58F21	Bromodomain testis-specific protein	DEG_APCC_KENBOX_2	683:687	SKENV	APC,CDC20,FZR1	0.9942	More...
Q6ZU35	Capping protein-inhibiting regulator of actin dynamics	DEG_APCC_KENBOX_2	1123:1127	SKENV	APC,CDC20,FZR1	0.7191	More...
Q8NI27	THO complex subunit 2	DEG_APCC_KENBOX_2	1375:1379	SKENV	APC,CDC20,FZR1	0.5524	More...
Q8TBA6	Golgin subfamily A member 5	DEG_APCC_KENBOX_2	198:202	SKENV	APC,CDC20,FZR1	0.9905	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_APCC_KENBOX_2	1525:1529	SKENV	APC,CDC20,FZR1	0.8967	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_APCC_KENBOX_2	442:446	SKENV	APC,CDC20,FZR1	0.9903	More...
Q2T9K0	Transmembrane protein 44	DEG_APCC_KENBOX_2	450:454	SKENV	APC,CDC20,FZR1	0.6922	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	731:735	SKENV	APC,CDC20,FZR1	0.8214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENV

Degron related mutations and impact score

Drug responses associated with THOC2 mutations

All proteins holding degron of SKENV