DegronMD

Uniprot ID: Q9NR99

Source protein: Matrix-remodeling-associated protein 5

Source gene: MXRA5

Class: DEG_APCC_KENBOX_2

Location: 1525:1529

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8967

ASA_SCORE: 72.72

COIL: 0.6014

CONS_SCORE: 0.3435

DSS_SCORE: 0.5633

HELIX: 0.0652

FCONS_SCORE: 1.1204

RIG_SCORE: 0.7162

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1517I	TCGA-BS-A0UF	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	0.1111
p.R1517I	DO41488	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1111
p.E1538K	TCGA-D9-A1JW	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	0.0833
p.E1538K	DO37786	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	0.0833
p.N1532K	TCGA-EE-A2GO	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	0.25
p.N1532K	DO37823	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	0.25
p.S1515C	TCGA-HU-A4GF	STAD	TCGA	SKENV	DEG_APCC_KENBOX_2	0.0556
p.S1515C	DO47885	STAD	ICGC	SKENV	DEG_APCC_KENBOX_2	0.0556
p.S1519F	TCGA-W3-A825	SKCM	TCGA	SKENV	DEG_APCC_KENBOX_2	0.1667
p.S1519F	DO51272	SKCM	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1667
p.Q1520E	DO229493	LAML	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1944
p.E1527K	DO222714	MELA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.7022
p.E1527K	DO229446	SKCA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.7022
p.Y1533C	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.2222
p.Y1533C	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.2222
p.F1530L	SIDM01577	Plasma Cell Myeloma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.3056
p.F1530L	ACH-000889	Myeloma	CCLE	SKENV	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_KENBOX_2	25:29	SKENV	APC,CDC20,FZR1	0.997	More...
Q58F21	Bromodomain testis-specific protein	DEG_APCC_KENBOX_2	683:687	SKENV	APC,CDC20,FZR1	0.9942	More...
Q6ZU35	Capping protein-inhibiting regulator of actin dynamics	DEG_APCC_KENBOX_2	1123:1127	SKENV	APC,CDC20,FZR1	0.7191	More...
Q8NI27	THO complex subunit 2	DEG_APCC_KENBOX_2	1375:1379	SKENV	APC,CDC20,FZR1	0.5524	More...
Q8TBA6	Golgin subfamily A member 5	DEG_APCC_KENBOX_2	198:202	SKENV	APC,CDC20,FZR1	0.9905	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_APCC_KENBOX_2	1525:1529	SKENV	APC,CDC20,FZR1	0.8967	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_APCC_KENBOX_2	442:446	SKENV	APC,CDC20,FZR1	0.9903	More...
Q2T9K0	Transmembrane protein 44	DEG_APCC_KENBOX_2	450:454	SKENV	APC,CDC20,FZR1	0.6922	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	731:735	SKENV	APC,CDC20,FZR1	0.8214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons