DegronMD

Uniprot ID: Q8TBA6

Source protein: Golgin subfamily A member 5

Source gene: GOLGA5

Class: DEG_APCC_KENBOX_2

Location: 198:202

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9905

ASA_SCORE: 115.84

COIL: 0.7064

CONS_SCORE: 0.7991

DSS_SCORE: 0.7667

HELIX: 0.2694

FCONS_SCORE: 0.9894

RIG_SCORE: 0.5533

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K199E	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.7022
p.K199E	ACH-000463	Lung Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.7022
p.K199E	NCI-H460	lung	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.7022
p.V202L	TCGA-A8-A06Y	BRCA	TCGA	SKENV	DEG_APCC_KENBOX_2	0.5654
p.V202L	DO4872	BRCA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.5654
p.G193V	SIDM01752	Pancreatic Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1944
p.G193V	ACH-000685	Pancreatic Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1944
p.E192D	SIDM01770	Gastric Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1667
p.E192D	ACH-000908	Gastric Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1667
p.P209R	TCGA-CG-5719	STAD	TCGA	SKENV	DEG_APCC_KENBOX_2	0.1389
p.P209R	DO38827	STAD	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1389
p.S190I	DO222478	ESCA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1111
p.S190R	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1111
p.S190R	SIDM01569	Hepatocellular Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1111
p.S190R	ACH-000734	Liver Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1111
p.S190R	ACH-002062	Lymphoma	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1111
p.S190R	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.1111

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58F21	Bromodomain testis-specific protein	DEG_APCC_KENBOX_2	683:687	SKENV	APC,CDC20,FZR1	0.9942	More...
Q6ZU35	Capping protein-inhibiting regulator of actin dynamics	DEG_APCC_KENBOX_2	1123:1127	SKENV	APC,CDC20,FZR1	0.7191	More...
Q8TBA6	Golgin subfamily A member 5	DEG_APCC_KENBOX_2	198:202	SKENV	APC,CDC20,FZR1	0.9905	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_APCC_KENBOX_2	1525:1529	SKENV	APC,CDC20,FZR1	0.8967	More...
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_KENBOX_2	25:29	SKENV	APC,CDC20,FZR1	0.997	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	731:735	SKENV	APC,CDC20,FZR1	0.8214	More...
Q8NI27	THO complex subunit 2	DEG_APCC_KENBOX_2	1375:1379	SKENV	APC,CDC20,FZR1	0.5524	More...
Q2T9K0	Transmembrane protein 44	DEG_APCC_KENBOX_2	450:454	SKENV	APC,CDC20,FZR1	0.6922	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_APCC_KENBOX_2	442:446	SKENV	APC,CDC20,FZR1	0.9903	More...

Showing 1 to 9 of 9 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons