DegronMD

Uniprot ID: Q8NI27

Source protein: THO complex subunit 2

Source gene: THOC2

Class: DEG_APCC_KENBOX_2

Location: 557:561

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5025

ASA_SCORE: 84.9

COIL: 0.537

CONS_SCORE: 0.5958

DSS_SCORE: 0.4193

HELIX: 0.4544

FCONS_SCORE: 1.0847

RIG_SCORE: 0.7873

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R555L	TCGA-49-AARE	LUAD	TCGA	TKENV	DEG_APCC_KENBOX_2	0.2778
p.R555C	TCGA-AX-A2HJ	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	0.2778
p.I552M	TCGA-EK-A3GK	CESC	TCGA	TKENV	DEG_APCC_KENBOX_2	0.1944
p.L553Q	DO1118	BRCA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.2222
p.I563V	DO14926	HNSC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.2778
p.I563V	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	TKENV	DEG_APCC_KENBOX_2	0.2778
p.L561M	DO229026	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.711
p.A550V	DO41871	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.25
p.L564F	DO52426	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.6944
p.A555V	DO43971	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.2778
p.P563S	SIDM00084	Glioblastoma	GDSC	TKENV	DEG_APCC_KENBOX_2	0.2778
p.P563S	ACH-000376	Brain Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	0.2778
p.P563S	SF295	central_nervous_system	COSMIC	TKENV	DEG_APCC_KENBOX_2	0.2778
p.V561M	ACH-000299	Leukemia	CCLE	TKENV	DEG_APCC_KENBOX_2	0.6097
p.A550T	CW-2	large_intestine	COSMIC	TKENV	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76070	Gamma-synuclein	DEG_APCC_KENBOX_2	44:48	TKENV	APC,CDC20,FZR1	0.9635	More...
Q8NI27	THO complex subunit 2	DEG_APCC_KENBOX_2	557:561	TKENV	APC,CDC20,FZR1	0.5025	More...
Q9GZU2	Paternally-expressed gene 3 protein	DEG_APCC_KENBOX_2	764:768	TKENV	APC,CDC20,FZR1	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons