DegronMD

Uniprot ID: O76070

Source protein: Gamma-synuclein

Source gene: SNCG

Class: DEG_APCC_KENBOX_2

Location: 44:48

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9635

ASA_SCORE: 84.22

COIL: 0.677

CONS_SCORE: 0.8931

DSS_SCORE: 0.3016

HELIX: 0.2

FCONS_SCORE: 0.987

RIG_SCORE: 0.7942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G41R	TCGA-85-8276	LUSC	TCGA	TKENV	DEG_APCC_KENBOX_2	0.25
p.G41R	DO26436	LUSC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.25
p.Q50H	TCGA-AP-A1DV	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	0.2778
p.Q50H	DO43186	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.2778
p.Y39C	TCGA-D1-A15X	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	0.6389
p.Y39C	DO43274	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.6389
p.E57K	TCGA-ND-A4WC	UCS	TCGA	TKENV	DEG_APCC_KENBOX_2	0.0833
p.M38I	DO228952	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.1667
p.M38I	DO229029	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.1667
p.V40L	DO229018	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.2222
p.G41E	DO222527	MELA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.25
p.E35K	SIDM00336	Melanoma	GDSC	TKENV	DEG_APCC_KENBOX_2	0.0833
p.E35K	ACH-000881	Skin Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	0.0833
p.E35K	MEL-JUSO	skin	COSMIC	TKENV	DEG_APCC_KENBOX_2	0.0833
p.V55A	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	TKENV	DEG_APCC_KENBOX_2	0.1389
p.V49A	ACH-000874	Leukemia	CCLE	TKENV	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76070	Gamma-synuclein	DEG_APCC_KENBOX_2	44:48	TKENV	APC,CDC20,FZR1	0.9635	More...
Q8NI27	THO complex subunit 2	DEG_APCC_KENBOX_2	557:561	TKENV	APC,CDC20,FZR1	0.5025	More...
Q9GZU2	Paternally-expressed gene 3 protein	DEG_APCC_KENBOX_2	764:768	TKENV	APC,CDC20,FZR1	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons