DegronMD - Q9GZU2(PEG3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y769C	TCGA-55-1596	LUAD	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.3056
p.Y769C	DO25481	LUAD	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.3056
p.E775D	TCGA-AG-A002	READ	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1389
p.S777Y	TCGA-AP-A1DV	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.0833
p.S777Y	DO43186	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.0833
p.S777F	TCGA-AX-A05Z	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.0833
p.S777F	DO40884	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.0833
p.S754F	TCGA-CV-6955	HNSC	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.0556
p.S754F	DO14338	HNSC	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.0556
p.S773L	TCGA-D3-A51G	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1944
p.S773L	TCGA-D3-A5GU	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1944
p.S773L	TCGA-EE-A2GI	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1944
p.S773L	DO37410	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1944
p.S773L	DO47700	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1944
p.S773L	DO47584	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1944
p.P763S	TCGA-DA-A95Z	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.3056
p.P763S	DO219481	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.3056
p.P763S	ACH-001038	Bone Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.3056
p.E766K	TCGA-FW-A3R5	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation altering degron motif	0.7022
p.E766K	DO220891	MELA	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation altering degron motif	0.7022
p.E766K	DO222908	MELA	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation altering degron motif	0.7022
p.E766K	DO229502	SKCA	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation altering degron motif	0.7022
p.E766K	DO37406	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation altering degron motif	0.7022
p.E758K	TCGA-FW-A3R5	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1667
p.E758K	DO37406	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1667
p.K761T	TCGA-L5-A8NS	ESCA	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation substituting flanking lysine	0.3611
p.K761T	TCGA-VQ-A91Z	STAD	TCGA	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation substituting flanking lysine	0.3611
p.K761T	DO233170	GACA	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation substituting flanking lysine	0.3611
p.K761T	DO51792	STAD	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation substituting flanking lysine	0.3611
p.K772N	DO222762	COCA	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation substituting flanking lysine	0.3333
p.S754P	DO10809	EOPC	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.0556
p.K765T	DO234333	ESAD	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation altering degron motif	0.7306
p.K761M	DO233698	GACA	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation substituting flanking lysine	0.3611
p.P756T	DO229027	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1111
p.K761E	SIDM00216	Colorectal Carcinoma	GDSC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation substituting flanking lysine	0.3611
p.K761E	ACH-000989	Colon/Colorectal Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation substituting flanking lysine	0.3611
p.K761E	SNU-175	large intestine	COSMIC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation substituting flanking lysine	0.3611
p.R776M	SIDM00660	Colorectal Carcinoma	GDSC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1111
p.R776M	ACH-000985	Colon/Colorectal Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1111
p.R776M	LS-411N	large intestine	COSMIC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.1111
p.K777R	SW156	kidney	COSMIC	TKENV	DEG_APCC_KENBOX_2	764:768	Mutation rewiring degron network	0.0833

Kaplan plot for PEG3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PEG3

UniProt ID: Q9GZU2

Entrez ID: 5178

Protein name: Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PEG3 in