DegronMD

Uniprot ID: Q9GZU2

Source protein: Paternally-expressed gene 3 protein

Source gene: PEG3

Class: DEG_APCC_KENBOX_2

Location: 764:768

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9993

ASA_SCORE: 79.44

COIL: 0.9056

CONS_SCORE: 0.247

DSS_SCORE: 0.4639

HELIX: 0.0162

FCONS_SCORE: 0.5308

RIG_SCORE: 0.7697

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y769C	TCGA-55-1596	LUAD	TCGA	TKENV	DEG_APCC_KENBOX_2	0.3056
p.Y769C	DO25481	LUAD	ICGC	TKENV	DEG_APCC_KENBOX_2	0.3056
p.E775D	TCGA-AG-A002	READ	TCGA	TKENV	DEG_APCC_KENBOX_2	0.1389
p.S777Y	TCGA-AP-A1DV	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	0.0833
p.S777Y	DO43186	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.0833
p.S777F	TCGA-AX-A05Z	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	0.0833
p.S777F	DO40884	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.0833
p.S754F	TCGA-CV-6955	HNSC	TCGA	TKENV	DEG_APCC_KENBOX_2	0.0556
p.S754F	DO14338	HNSC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.0556
p.S773L	TCGA-D3-A51G	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	0.1944
p.S773L	TCGA-D3-A5GU	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	0.1944
p.S773L	TCGA-EE-A2GI	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	0.1944
p.S773L	DO37410	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	0.1944
p.S773L	DO47700	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	0.1944
p.S773L	DO47584	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	0.1944
p.P763S	TCGA-DA-A95Z	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	0.3056
p.P763S	DO219481	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	0.3056
p.P763S	ACH-001038	Bone Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	0.3056
p.E766K	TCGA-FW-A3R5	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	0.7022
p.E766K	DO220891	MELA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.7022
p.E766K	DO222908	MELA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.7022
p.E766K	DO229502	SKCA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.7022
p.E766K	DO37406	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	0.7022
p.E758K	TCGA-FW-A3R5	SKCM	TCGA	TKENV	DEG_APCC_KENBOX_2	0.1667
p.E758K	DO37406	SKCM	ICGC	TKENV	DEG_APCC_KENBOX_2	0.1667
p.K761T	TCGA-L5-A8NS	ESCA	TCGA	TKENV	DEG_APCC_KENBOX_2	0.3611
p.K761T	TCGA-VQ-A91Z	STAD	TCGA	TKENV	DEG_APCC_KENBOX_2	0.3611
p.K761T	DO233170	GACA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.3611
p.K761T	DO51792	STAD	ICGC	TKENV	DEG_APCC_KENBOX_2	0.3611
p.K772N	DO222762	COCA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.3333
p.S754P	DO10809	EOPC	ICGC	TKENV	DEG_APCC_KENBOX_2	0.0556
p.K765T	DO234333	ESAD	ICGC	TKENV	DEG_APCC_KENBOX_2	0.7306
p.K761M	DO233698	GACA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.3611
p.P756T	DO229027	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	0.1111
p.K761E	SIDM00216	Colorectal Carcinoma	GDSC	TKENV	DEG_APCC_KENBOX_2	0.3611
p.K761E	ACH-000989	Colon/Colorectal Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	0.3611
p.K761E	SNU-175	large_intestine	COSMIC	TKENV	DEG_APCC_KENBOX_2	0.3611
p.R776M	SIDM00660	Colorectal Carcinoma	GDSC	TKENV	DEG_APCC_KENBOX_2	0.1111
p.R776M	ACH-000985	Colon/Colorectal Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	0.1111
p.R776M	LS-411N	large_intestine	COSMIC	TKENV	DEG_APCC_KENBOX_2	0.1111
p.K777R	SW156	kidney	COSMIC	TKENV	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76070	Gamma-synuclein	DEG_APCC_KENBOX_2	44:48	TKENV	APC,CDC20,FZR1	0.9635	More...
Q8NI27	THO complex subunit 2	DEG_APCC_KENBOX_2	557:561	TKENV	APC,CDC20,FZR1	0.5025	More...
Q9GZU2	Paternally-expressed gene 3 protein	DEG_APCC_KENBOX_2	764:768	TKENV	APC,CDC20,FZR1	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TKENV

Degron related mutations and impact score

Drug responses associated with PEG3 mutations

All proteins holding degron of TKENV