DegronMD - O76070(SNCG)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G41R	TCGA-85-8276	LUSC	TCGA	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.25
p.G41R	DO26436	LUSC	ICGC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.25
p.Q50H	TCGA-AP-A1DV	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.2778
p.Q50H	DO43186	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.2778
p.Y39C	TCGA-D1-A15X	UCEC	TCGA	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation blocking phosphorylation signal	0.6389
p.Y39C	DO43274	UCEC	ICGC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation blocking phosphorylation signal	0.6389
p.E57K	TCGA-ND-A4WC	UCS	TCGA	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.0833
p.M38I	DO228952	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.1667
p.M38I	DO229029	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.1667
p.V40L	DO229018	LICA	ICGC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.2222
p.G41E	DO222527	MELA	ICGC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.25
p.E35K	SIDM00336	Melanoma	GDSC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.0833
p.E35K	ACH-000881	Skin Cancer	CCLE	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.0833
p.E35K	MEL-JUSO	skin	COSMIC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.0833
p.V55A	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.1389
p.V49A	ACH-000874	Leukemia	CCLE	TKENV	DEG_APCC_KENBOX_2	44:48	Mutation rewiring degron network	0.3056

Kaplan plot for SNCG in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNCG

UniProt ID: O76070

Entrez ID: 6623

Protein name: Gamma-synuclein (Breast cancer-specific gene 1 protein) (Persyn) (Synoretin) (SR)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SNCG in