DegronMD - Q6P2E9(EDC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S638N	TCGA-38-4629	LUAD	TCGA	AMSST	DEG_SPOP_SBC_1	635:639	Mutation altering degron motif	0.7069
p.S638N	DO23771	LUAD	ICGC	AMSST	DEG_SPOP_SBC_1	635:639	Mutation altering degron motif	0.7069
p.Q607H	TCGA-AA-3672	COAD	TCGA	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation rewiring degron network	0.25
p.Q607H	TCGA-AA-3672	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	612:616	Mutation rewiring degron network	0.1944
p.Q607H	DO9010	COAD	ICGC	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation rewiring degron network	0.25
p.Q607H	DO9010	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	612:616	Mutation rewiring degron network	0.1944
p.R678S	TCGA-AA-A01P	COAD	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.7427
p.R678S	DO8642	COAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.7427
p.A597T	TCGA-AX-A1C5	UCEC	TCGA	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation rewiring degron network	0.2778
p.A597T	DO228138	PBCA	ICGC	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation rewiring degron network	0.2778
p.A597T	DO41422	UCEC	ICGC	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation rewiring degron network	0.2778
p.A597T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation rewiring degron network	0.2778
p.A597T	ACH-001127	Leukemia	CCLE	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation rewiring degron network	0.2778
p.A597T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation rewiring degron network	0.2778
p.S668G	TCGA-BR-4361	STAD	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.0833
p.S668G	DO38887	STAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.0833
p.A687T	TCGA-CG-5723	STAD	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.2778
p.A687T	DO38376	STAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.2778
p.S626I	TCGA-CV-6955	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	612:616	Mutation rewiring degron network	0.0556
p.S626I	TCGA-CV-6955	HNSC	TCGA	AMSST	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.0833
p.S626I	DO14338	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	612:616	Mutation rewiring degron network	0.0556
p.S626I	DO14338	HNSC	ICGC	AMSST	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.0833
p.P682S	TCGA-D5-6530	COAD	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.5641
p.P682S	DO8312	COAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.5641
p.P686S	TCGA-EE-A2GO	SKCM	TCGA	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.3056
p.P686S	DO37823	SKCM	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.3056
p.S638I	TCGA-GN-A265	SKCM	TCGA	AMSST	DEG_SPOP_SBC_1	635:639	Mutation altering degron motif	0.7341
p.S638I	DO37491	SKCM	ICGC	AMSST	DEG_SPOP_SBC_1	635:639	Mutation altering degron motif	0.7341
p.T647I	TCGA-XK-AAIW	PRAD	TCGA	AMSST	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1111
p.T647I	DO51407	PRAD	ICGC	AMSST	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1111
p.S1091F	TCGA-YD-A9TA	SKCM	TCGA	MKENI	DEG_APCC_KENBOX_2	1081:1085	Mutation rewiring degron network	0.1667
p.S1091F	DO219503	SKCM	ICGC	MKENI	DEG_APCC_KENBOX_2	1081:1085	Mutation rewiring degron network	0.1667
p.S670N	DO234462	ESAD	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.1389
p.S645C	DO233260	GACA	ICGC	AMSST	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1667
p.S629F	DO231140	LAML	ICGC	AMSST	DEG_SPOP_SBC_1	635:639	Mutation rewiring degron network	0.1667
p.A1071S	DO229018	LICA	ICGC	MKENI	DEG_APCC_KENBOX_2	1081:1085	Mutation rewiring degron network	0.0556
p.L605F	DO229032	LICA	ICGC	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation rewiring degron network	0.3056
p.L605F	DO229032	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	612:616	Mutation rewiring degron network	0.1389
p.A675G	DO230950	LUSC	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.2778
p.A675G	DO224638	LUSC	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.2778
p.L684P	DO229268	THCA	ICGC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation altering degron motif	0.7582
p.A1071T	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	MKENI	DEG_APCC_KENBOX_2	1081:1085	Mutation rewiring degron network	0.0556
p.A1071T	SIDM00449	B-Lymphoblastic Leukemia	GDSC	MKENI	DEG_APCC_KENBOX_2	1081:1085	Mutation rewiring degron network	0.0556
p.P688A	SIDM01126	Small Cell Lung Carcinoma	GDSC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.25
p.P688A	NCI-H64	lung	COSMIC	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.25
p.A603T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation altering degron motif	0.6028
p.A603T	ACH-001127	Leukemia	CCLE	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation altering degron motif	0.6028
p.A603T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	MTPSAS	DEG_SCF_FBW7_1	599:604	Mutation altering degron motif	0.6028
p.S620G	ACH-000623	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	612:616	Mutation rewiring degron network	0.2222
p.S622N	ACH-000890	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	612:616	Mutation blocking phosphorylation signal	0.6111
p.S624N	ACH-000952	Prostate Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	612:616	Mutation blocking phosphorylation signal	0.5556
p.G618S	ACH-000955	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	612:616	Mutation rewiring degron network	0.2778
p.A675E	ACH-001645	Skin Cancer	CCLE	PRGLLPGLL	DEG_APCC_DBOX_1	677:685	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EDC4

UniProt ID: Q6P2E9

Entrez ID: 23644

Protein name: Enhancer of mRNA-decapping protein 4 (Autoantigen Ge-1) (Autoantigen RCD-8) (Human enhancer of decapping large subunit) (Hedls)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EDC4 in