DegronMD

Uniprot ID: Q6P2E9

Source protein: Enhancer of mRNA-decapping protein 4

Source gene: EDC4

Class: DEG_SCF_FBW7_1

Location: 599:604

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 71.4667

COIL: 0.8192

CONS_SCORE: 0.2978

DSS_SCORE: 0.5294

HELIX: 0.143

FCONS_SCORE: 0.99

RIG_SCORE: 0.7241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q607H	TCGA-AA-3672	COAD	TCGA	MTPSAS	DEG_SCF_FBW7_1	0.25
p.Q607H	DO9010	COAD	ICGC	MTPSAS	DEG_SCF_FBW7_1	0.25
p.A597T	TCGA-AX-A1C5	UCEC	TCGA	MTPSAS	DEG_SCF_FBW7_1	0.2778
p.A597T	DO228138	PBCA	ICGC	MTPSAS	DEG_SCF_FBW7_1	0.2778
p.A597T	DO41422	UCEC	ICGC	MTPSAS	DEG_SCF_FBW7_1	0.2778
p.A597T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	MTPSAS	DEG_SCF_FBW7_1	0.2778
p.A597T	ACH-001127	Leukemia	CCLE	MTPSAS	DEG_SCF_FBW7_1	0.2778
p.A597T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	MTPSAS	DEG_SCF_FBW7_1	0.2778
p.L605F	DO229032	LICA	ICGC	MTPSAS	DEG_SCF_FBW7_1	0.3056
p.A603T	SIDM00145	T-Lymphoblastic Leukemia	GDSC	MTPSAS	DEG_SCF_FBW7_1	0.6028
p.A603T	ACH-001127	Leukemia	CCLE	MTPSAS	DEG_SCF_FBW7_1	0.6028
p.A603T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	MTPSAS	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P2E9	Enhancer of mRNA-decapping protein 4	DEG_SCF_FBW7_1	599:604	MTPSAS	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons