DegronMD

Uniprot ID: Q6P2E9

Source protein: Enhancer of mRNA-decapping protein 4

Source gene: EDC4

Class: DEG_SPOP_SBC_1

Location: 635:639

E3 ligase: SPOP

DEGRON score: 0.9795

ASA_SCORE: 83.78

COIL: 0.8278

CONS_SCORE: 0.3579

DSS_SCORE: 0.4734

HELIX: 0.1594

FCONS_SCORE: 1.0635

RIG_SCORE: 0.585

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S638N	TCGA-38-4629	LUAD	TCGA	AMSST	DEG_SPOP_SBC_1	0.7069
p.S638N	DO23771	LUAD	ICGC	AMSST	DEG_SPOP_SBC_1	0.7069
p.S626I	TCGA-CV-6955	HNSC	TCGA	AMSST	DEG_SPOP_SBC_1	0.0833
p.S626I	DO14338	HNSC	ICGC	AMSST	DEG_SPOP_SBC_1	0.0833
p.S638I	TCGA-GN-A265	SKCM	TCGA	AMSST	DEG_SPOP_SBC_1	0.7341
p.S638I	DO37491	SKCM	ICGC	AMSST	DEG_SPOP_SBC_1	0.7341
p.T647I	TCGA-XK-AAIW	PRAD	TCGA	AMSST	DEG_SPOP_SBC_1	0.1111
p.T647I	DO51407	PRAD	ICGC	AMSST	DEG_SPOP_SBC_1	0.1111
p.S645C	DO233260	GACA	ICGC	AMSST	DEG_SPOP_SBC_1	0.1667
p.S629F	DO231140	LAML	ICGC	AMSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P2E9	Enhancer of mRNA-decapping protein 4	DEG_SPOP_SBC_1	635:639	AMSST	SPOP	0.9795	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	26:30	AMSST	SPOP	0.9002	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons