DegronMD

Uniprot ID: Q96M27

Source protein: Protein PRRC1

Source gene: PRRC1

Class: DEG_SPOP_SBC_1

Location: 26:30

E3 ligase: SPOP

DEGRON score: 0.9002

ASA_SCORE: 85.14

COIL: 0.932

CONS_SCORE: 0.2407

DSS_SCORE: 0.5087

HELIX: 0.0396

FCONS_SCORE: 0.7266

RIG_SCORE: 0.6643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G21W	TCGA-AX-A1CE	UCEC	TCGA	AMSST	DEG_SPOP_SBC_1	0.1944
p.G21W	TCGA-D3-A2J6	SKCM	TCGA	AMSST	DEG_SPOP_SBC_1	0.1944
p.G21W	DO37901	SKCM	ICGC	AMSST	DEG_SPOP_SBC_1	0.1944
p.G21W	DO42280	UCEC	ICGC	AMSST	DEG_SPOP_SBC_1	0.1944
p.V32F	DO228181	PBCA	ICGC	AMSST	DEG_SPOP_SBC_1	0.2778
p.P31A	SIDM00819	Kidney Carcinoma	GDSC	AMSST	DEG_SPOP_SBC_1	0.3056
p.P31A	ACH-002189	Kidney Cancer	CCLE	AMSST	DEG_SPOP_SBC_1	0.3056
p.P31A	RCC-FG2	kidney	COSMIC	AMSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P2E9	Enhancer of mRNA-decapping protein 4	DEG_SPOP_SBC_1	635:639	AMSST	SPOP	0.9795	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	26:30	AMSST	SPOP	0.9002	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons