DegronMD - Q96M27(PRRC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G103S	TCGA-06-1805	GBM	TCGA	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.G103S	DO11567	GBM	ICGC	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.G6A	TCGA-44-4112	LUAD	TCGA	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.3056
p.G6A	DO26032	LUAD	ICGC	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.3056
p.V45L	TCGA-AL-3467	KIRP	TCGA	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1667
p.P125H	TCGA-AP-A1DK	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.P125H	DO42033	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.G21W	TCGA-AX-A1CE	UCEC	TCGA	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.1389
p.G21W	TCGA-AX-A1CE	UCEC	TCGA	AMSST	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.1944
p.G21W	TCGA-D3-A2J6	SKCM	TCGA	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.1389
p.G21W	TCGA-D3-A2J6	SKCM	TCGA	AMSST	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.1944
p.G21W	DO37901	SKCM	ICGC	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.1389
p.G21W	DO37901	SKCM	ICGC	AMSST	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.1944
p.G21W	DO42280	UCEC	ICGC	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.1389
p.G21W	DO42280	UCEC	ICGC	AMSST	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.1944
p.A123V	TCGA-AX-A2HA	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.A123V	DO42504	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.M2I	TCGA-EE-A20F	SKCM	TCGA	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.1944
p.M2I	DO37961	SKCM	ICGC	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.1944
p.S39Y	TCGA-EI-6917	READ	TCGA	AATSS	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.8231
p.S39Y	DO36881	READ	ICGC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.8231
p.S46T	TCGA-QG-A5Z2	COAD	TCGA	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1389
p.S46T	DO44096	COAD	ICGC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1389
p.S46F	TCGA-YG-AA3O	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1389
p.S46F	DO51299	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.1389
p.A35V	DO228123	EOPC	ICGC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation altering degron motif	0.5825
p.G6V	DO229027	LICA	ICGC	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.3056
p.A116S	DO229041	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.3056
p.G103C	DO229045	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.G103D	DO229054	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1111
p.E3V	DO25104	LUAD	ICGC	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.2222
p.P106S	DO222710	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.P12L	DO50718	ORCA	ICGC	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation altering degron motif	0.6471
p.V32F	DO228181	PBCA	ICGC	AMSST	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.2778
p.V32F	DO228181	PBCA	ICGC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.25
p.S41F	SIDM00562	Breast Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.S41F	SIDM01750	Melanoma	GDSC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.S41F	ACH-000801	Skin Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.S41F	ACH-002163	Breast Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.S41F	MRK-nu-1	breast	COSMIC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2778
p.P31A	SIDM00819	Kidney Carcinoma	GDSC	AMSST	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.3056
p.P31A	SIDM00819	Kidney Carcinoma	GDSC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2222
p.P31A	ACH-002189	Kidney Cancer	CCLE	AMSST	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.3056
p.P31A	ACH-002189	Kidney Cancer	CCLE	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2222
p.P31A	RCC-FG2	kidney	COSMIC	AMSST	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.3056
p.P31A	RCC-FG2	kidney	COSMIC	AATSS	DEG_SPOP_SBC_1	35:39	Mutation rewiring degron network	0.2222
p.P125S	SIDM01770	Gastric Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.G13W	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation altering degron motif	0.6714
p.G13W	ACH-000891	Lung Cancer	CCLE	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation altering degron motif	0.6714
p.G13V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation altering degron motif	0.6421
p.G13V	ACH-000891	Lung Cancer	CCLE	IETTPPGT	DEG_SCF_FBW7_1	7:14	Mutation altering degron motif	0.6421

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRRC1

UniProt ID: Q96M27

Entrez ID: 133619

Protein name: Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRRC1 in