DegronMD

Uniprot ID: Q96M27

Source protein: Protein PRRC1

Source gene: PRRC1

Class: DEG_SCF_FBW7_1

Location: 7:14

E3 ligase: FBXW7

DEGRON score: 0.9733

ASA_SCORE: 89.85

COIL: 0.949

CONS_SCORE: 0.4509

DSS_SCORE: 0.8581

HELIX: 0.0072

FCONS_SCORE: 1.1115

RIG_SCORE: 0.5708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G6A	TCGA-44-4112	LUAD	TCGA	IETTPPGT	DEG_SCF_FBW7_1	0.3056
p.G6A	DO26032	LUAD	ICGC	IETTPPGT	DEG_SCF_FBW7_1	0.3056
p.G21W	TCGA-AX-A1CE	UCEC	TCGA	IETTPPGT	DEG_SCF_FBW7_1	0.1389
p.G21W	TCGA-D3-A2J6	SKCM	TCGA	IETTPPGT	DEG_SCF_FBW7_1	0.1389
p.G21W	DO37901	SKCM	ICGC	IETTPPGT	DEG_SCF_FBW7_1	0.1389
p.G21W	DO42280	UCEC	ICGC	IETTPPGT	DEG_SCF_FBW7_1	0.1389
p.M2I	TCGA-EE-A20F	SKCM	TCGA	IETTPPGT	DEG_SCF_FBW7_1	0.1944
p.M2I	DO37961	SKCM	ICGC	IETTPPGT	DEG_SCF_FBW7_1	0.1944
p.G6V	DO229027	LICA	ICGC	IETTPPGT	DEG_SCF_FBW7_1	0.3056
p.E3V	DO25104	LUAD	ICGC	IETTPPGT	DEG_SCF_FBW7_1	0.2222
p.P12L	DO50718	ORCA	ICGC	IETTPPGT	DEG_SCF_FBW7_1	0.6471
p.G13W	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IETTPPGT	DEG_SCF_FBW7_1	0.6714
p.G13W	ACH-000891	Lung Cancer	CCLE	IETTPPGT	DEG_SCF_FBW7_1	0.6714
p.G13V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	IETTPPGT	DEG_SCF_FBW7_1	0.6421
p.G13V	ACH-000891	Lung Cancer	CCLE	IETTPPGT	DEG_SCF_FBW7_1	0.6421

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96M27	Protein PRRC1	DEG_SCF_FBW7_1	7:14	IETTPPGT	FBXW7	0.9733	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons