DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PPSTS
Uniprot ID:
Q96M27
Source protein:
Protein PRRC1
Source gene:
PRRC1
Class:
DEG_SPOP_SBC_1
Location:
111:115
E3 ligase:
SPOP
DEGRON score:
0.9952
ASA_SCORE:
77.14
COIL:
0.9538
CONS_SCORE:
0.338
DSS_SCORE:
0.5431
HELIX:
0.021
FCONS_SCORE:
1.0924
RIG_SCORE:
0.6039
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G103S
TCGA-06-1805
GBM
TCGA
PPSTS
DEG_SPOP_SBC_1
0.1111
p.G103S
DO11567
GBM
ICGC
PPSTS
DEG_SPOP_SBC_1
0.1111
p.P125H
TCGA-AP-A1DK
UCEC
TCGA
PPSTS
DEG_SPOP_SBC_1
0.0556
p.P125H
DO42033
UCEC
ICGC
PPSTS
DEG_SPOP_SBC_1
0.0556
p.A123V
TCGA-AX-A2HA
UCEC
TCGA
PPSTS
DEG_SPOP_SBC_1
0.1111
p.A123V
DO42504
UCEC
ICGC
PPSTS
DEG_SPOP_SBC_1
0.1111
p.A116S
DO229041
LICA
ICGC
PPSTS
DEG_SPOP_SBC_1
0.3056
p.G103C
DO229045
LICA
ICGC
PPSTS
DEG_SPOP_SBC_1
0.1111
p.G103D
DO229054
LICA
ICGC
PPSTS
DEG_SPOP_SBC_1
0.1111
p.P106S
DO222710
MELA
ICGC
PPSTS
DEG_SPOP_SBC_1
0.1944
p.P125S
SIDM01770
Gastric Carcinoma
GDSC
PPSTS
DEG_SPOP_SBC_1
0.0556
Drug responses associated with PRRC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPSTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00160
Unconventional myosin-If
DEG_SPOP_SBC_1
984:988
PPSTS
SPOP
0.9842
More...
O14746
Telomerase reverse transcriptase
DEG_SPOP_SBC_1
307:311
PPSTS
SPOP
0.9923
More...
O15018
PDZ domain-containing protein 2
DEG_SPOP_SBC_1
904:908
PPSTS
SPOP
0.8193
More...
O43516
WAS/WASL-interacting protein family member 1
DEG_SPOP_SBC_1
432:436
PPSTS
SPOP
0.9568
More...
O43526
Potassium voltage-gated channel subfamily KQT member 2
DEG_SPOP_SBC_1
713:717
PPSTS
SPOP
0.8569
More...
O60312
Phospholipid-transporting ATPase VA
DEG_SPOP_SBC_1
959:963
PPSTS
SPOP
0.8225
More...
O75175
CCR4-NOT transcription complex subunit 3
DEG_SPOP_SBC_1
465:469
PPSTS
SPOP
0.8566
More...
O94933
SLIT and NTRK-like protein 3
DEG_SPOP_SBC_1
344:348
PPSTS
SPOP
0.5069
More...
P16150
Leukosialin
DEG_SPOP_SBC_1
66:70
PPSTS
SPOP
0.9993
More...
P35658
Nuclear pore complex protein Nup214
DEG_SPOP_SBC_1
577:581
PPSTS
SPOP
0.9911
More...
Q09472
Histone acetyltransferase p300
DEG_SPOP_SBC_1
954:958
PPSTS
SPOP
0.9959
More...
Q12830
Nucleosome-remodeling factor subunit BPTF
DEG_SPOP_SBC_1
84:88
PPSTS
SPOP
0.9962
More...
Q13207
T-box transcription factor TBX2
DEG_SPOP_SBC_1
631:635
PPSTS
SPOP
0.9985
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1374:1378
PPSTS
SPOP
0.9728
More...
Q14938
Nuclear factor 1 X-type
DEG_SPOP_SBC_1
269:273
PPSTS
SPOP
0.9824
More...
Q7Z570
Zinc finger protein 804A
DEG_SPOP_SBC_1
798:802
PPSTS
SPOP
0.9948
More...
Q7Z7A4
PX domain-containing protein kinase-like protein
DEG_SPOP_SBC_1
505:509
PPSTS
SPOP
0.794
More...
Q86TM6
E3 ubiquitin-protein ligase synoviolin
DEG_SPOP_SBC_1
406:410
PPSTS
SPOP
0.9932
More...
Q92918
Mitogen-activated protein kinase kinase kinase kinase 1
DEG_SPOP_SBC_1
442:446
PPSTS
SPOP
0.9477
More...
Q9BQ89
Protein FAM110A
DEG_SPOP_SBC_1
145:149
PPSTS
SPOP
0.8404
More...
Q9NS91
E3 ubiquitin-protein ligase RAD18
DEG_SPOP_SBC_1
190:194
PPSTS
SPOP
0.91
More...
Q9NYQ6
Cadherin EGF LAG seven-pass G-type receptor 1
DEG_SPOP_SBC_1
906:910
PPSTS
SPOP
0.9655
More...
Q9UHV7
Mediator of RNA polymerase II transcription subunit 13
DEG_SPOP_SBC_1
765:769
PPSTS
SPOP
0.9907
More...
Q9UMN6
Histone-lysine N-methyltransferase 2B
DEG_SPOP_SBC_1
419:423
PPSTS
SPOP
0.9758
More...
Q9UPN9
E3 ubiquitin-protein ligase TRIM33
DEG_SPOP_SBC_1
742:746
PPSTS
SPOP
0.9525
More...
Q9Y520
Protein PRRC2C
DEG_SPOP_SBC_1
1755:1759
PPSTS
SPOP
0.9881
More...
Q96M27
Protein PRRC1
DEG_SPOP_SBC_1
111:115
PPSTS
SPOP
0.9952
More...
Q5T8I3
Protein FAM102B
DEG_SPOP_SBC_1
152:156
PPSTS
SPOP
0.978
More...
Q96KW2
POM121-like protein 2
DEG_SPOP_SBC_1
130:134
PPSTS
SPOP
0.5646
More...
Q96KW2
POM121-like protein 2
DEG_SPOP_SBC_1
483:487
PPSTS
SPOP
0.9614
More...
Q8IXP5
Uncharacterized protein C11orf53
DEG_SPOP_SBC_1
130:134
PPSTS
SPOP
0.9669
More...