DegronMD

Uniprot ID: O94933

Source protein: SLIT and NTRK-like protein 3

Source gene: SLITRK3

Class: DEG_SPOP_SBC_1

Location: 344:348

E3 ligase: SPOP

DEGRON score: 0.5069

ASA_SCORE: 48.6

COIL: 0.8174

CONS_SCORE: 0.6391

DSS_SCORE: 0.8409

HELIX: 0.1252

FCONS_SCORE: 0.9713

RIG_SCORE: 0.551

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P358S	TCGA-18-4083	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.0556
p.P358S	DO26504	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.R340G	TCGA-55-8507	LUAD	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340G	DO45412	LUAD	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340G	SIDM01146	Gastric Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340G	ACH-000932	Gastric Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340G	NCI-SNU-1	stomach	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340L	TCGA-60-2725	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340L	DO26674	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.Y352C	TCGA-96-7545	LUSC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.Y352C	DO26492	LUSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R343M	TCGA-A5-A0G2	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.3056
p.R343M	TCGA-EO-A22U	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.3056
p.R343M	DO41235	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.3056
p.R343M	DO43755	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.3056
p.R340Q	TCGA-AP-A056	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340Q	TCGA-CN-A6V3	HNSC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340Q	TCGA-GF-A6C9	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340Q	DO52050	HNSC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340Q	DO51254	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.R340Q	DO43971	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2222
p.S348F	TCGA-ER-A42L	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	0.7982
p.S348F	DO223910	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	0.7982
p.P345L	TCGA-FI-A2D0	UCEC	TCGA	PPSTS	DEG_SPOP_SBC_1	0.6471
p.P345L	DO43891	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	0.6471
p.P358T	DO222404	BTCA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.0556
p.Q338K	DO228985	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.1667
p.P342Q	DO229022	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.2778
p.T341K	DO229031	LICA	ICGC	PPSTS	DEG_SPOP_SBC_1	0.25
p.S346A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	0.7588
p.S346A	ACH-000920	Leukemia	CCLE	PPSTS	DEG_SPOP_SBC_1	0.7588
p.P335L	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.0833
p.P335L	Calu-3	lung	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.0833
p.Q357K	SIDM00120	Prostate Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	0.0833
p.Q357K	SIDM00507	Other Solid Cancers	GDSC	PPSTS	DEG_SPOP_SBC_1	0.0833
p.Q357K	ACH-000979	Prostate Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.0833
p.Q357K	ACH-001490	Lung Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	0.0833
p.Q357K	COR-L321	NS	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.0833
p.Q357K	DU-145	prostate	COSMIC	PPSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00160	Unconventional myosin-If	DEG_SPOP_SBC_1	984:988	PPSTS	SPOP	0.9842	More...
O14746	Telomerase reverse transcriptase	DEG_SPOP_SBC_1	307:311	PPSTS	SPOP	0.9923	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	904:908	PPSTS	SPOP	0.8193	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	432:436	PPSTS	SPOP	0.9568	More...
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_SPOP_SBC_1	713:717	PPSTS	SPOP	0.8569	More...
O60312	Phospholipid-transporting ATPase VA	DEG_SPOP_SBC_1	959:963	PPSTS	SPOP	0.8225	More...
O75175	CCR4-NOT transcription complex subunit 3	DEG_SPOP_SBC_1	465:469	PPSTS	SPOP	0.8566	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	344:348	PPSTS	SPOP	0.5069	More...
P16150	Leukosialin	DEG_SPOP_SBC_1	66:70	PPSTS	SPOP	0.9993	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	577:581	PPSTS	SPOP	0.9911	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	954:958	PPSTS	SPOP	0.9959	More...
Q12830	Nucleosome-remodeling factor subunit BPTF	DEG_SPOP_SBC_1	84:88	PPSTS	SPOP	0.9962	More...
Q13207	T-box transcription factor TBX2	DEG_SPOP_SBC_1	631:635	PPSTS	SPOP	0.9985	More...
Q14676	Mediator of DNA damage checkpoint protein 1	DEG_SPOP_SBC_1	1374:1378	PPSTS	SPOP	0.9728	More...
Q14938	Nuclear factor 1 X-type	DEG_SPOP_SBC_1	269:273	PPSTS	SPOP	0.9824	More...
Q7Z570	Zinc finger protein 804A	DEG_SPOP_SBC_1	798:802	PPSTS	SPOP	0.9948	More...
Q7Z7A4	PX domain-containing protein kinase-like protein	DEG_SPOP_SBC_1	505:509	PPSTS	SPOP	0.794	More...
Q86TM6	E3 ubiquitin-protein ligase synoviolin	DEG_SPOP_SBC_1	406:410	PPSTS	SPOP	0.9932	More...
Q92918	Mitogen-activated protein kinase kinase kinase kinase 1	DEG_SPOP_SBC_1	442:446	PPSTS	SPOP	0.9477	More...
Q9BQ89	Protein FAM110A	DEG_SPOP_SBC_1	145:149	PPSTS	SPOP	0.8404	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	190:194	PPSTS	SPOP	0.91	More...
Q9NYQ6	Cadherin EGF LAG seven-pass G-type receptor 1	DEG_SPOP_SBC_1	906:910	PPSTS	SPOP	0.9655	More...
Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	DEG_SPOP_SBC_1	765:769	PPSTS	SPOP	0.9907	More...
Q9UMN6	Histone-lysine N-methyltransferase 2B	DEG_SPOP_SBC_1	419:423	PPSTS	SPOP	0.9758	More...
Q9UPN9	E3 ubiquitin-protein ligase TRIM33	DEG_SPOP_SBC_1	742:746	PPSTS	SPOP	0.9525	More...
Q9Y520	Protein PRRC2C	DEG_SPOP_SBC_1	1755:1759	PPSTS	SPOP	0.9881	More...
Q96M27	Protein PRRC1	DEG_SPOP_SBC_1	111:115	PPSTS	SPOP	0.9952	More...
Q5T8I3	Protein FAM102B	DEG_SPOP_SBC_1	152:156	PPSTS	SPOP	0.978	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.5646	More...
Q96KW2	POM121-like protein 2	DEG_SPOP_SBC_1	483:487	PPSTS	SPOP	0.9614	More...
Q8IXP5	Uncharacterized protein C11orf53	DEG_SPOP_SBC_1	130:134	PPSTS	SPOP	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSTS

Degron related mutations and impact score

Drug responses associated with SLITRK3 mutations

All proteins holding degron of PPSTS