DegronMD - Q9NS91(RAD18)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S444L	TCGA-34-2605	LUSC	TCGA	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0556
p.S444L	TCGA-BR-8678	STAD	TCGA	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0556
p.S444L	DO26471	LUSC	ICGC	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0556
p.S444L	DO47957	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0556
p.S144F	TCGA-55-A493	LUAD	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation blocking phosphorylation signal	0.6111
p.S144F	DO26328	LUAD	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation blocking phosphorylation signal	0.6111
p.V430A	TCGA-A5-A0G2	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.5825
p.V430A	DO41235	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation altering degron motif	0.5825
p.S421Y	TCGA-A5-A2K5	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0833
p.S421Y	DO41379	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.0833
p.K110N	TCGA-AG-A002	READ	TCGA	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation blocking ubiquitination signal	0.6111
p.K110N	TCGA-AG-A002	READ	TCGA	PASSS	DEG_SPOP_SBC_1	104:108	Mutation blocking ubiquitination signal	0.7222
p.K110N	TCGA-DK-A6AW	BLCA	TCGA	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation blocking ubiquitination signal	0.6111
p.K110N	TCGA-DK-A6AW	BLCA	TCGA	PASSS	DEG_SPOP_SBC_1	104:108	Mutation blocking ubiquitination signal	0.7222
p.K110N	DO48566	BLCA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation blocking ubiquitination signal	0.6111
p.K110N	DO48566	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	104:108	Mutation blocking ubiquitination signal	0.7222
p.K110N	DO233718	GACA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation blocking ubiquitination signal	0.6111
p.K110N	DO233718	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	104:108	Mutation blocking ubiquitination signal	0.7222
p.S155R	TCGA-BS-A0UF	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation blocking phosphorylation signal	0.75
p.S155R	DO41488	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation blocking phosphorylation signal	0.75
p.V199A	TCGA-DX-AB2E	SARC	TCGA	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1944
p.V199A	DO220073	SARC	ICGC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1944
p.P182H	TCGA-EB-A299	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.P182H	DO37794	SKCM	ICGC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.1111
p.P100L	TCGA-EE-A2GO	SKCM	TCGA	PASSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.2222
p.P100L	DO37823	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.2222
p.E140K	TCGA-EO-A3B0	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.0556
p.E140K	DO219773	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.0556
p.C439Y	TCGA-EY-A548	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1944
p.C439Y	DO48173	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1944
p.S438L	TCGA-GN-A8LK	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2222
p.S438L	DO51259	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.2222
p.V120L	TCGA-LN-A9FP	ESCA	TCGA	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.5654
p.I427V	TCGA-TS-A8AY	MESO	TCGA	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.25
p.P104H	TCGA-UC-A7PF	CESC	TCGA	PASSS	DEG_SPOP_SBC_1	104:108	Mutation altering degron motif	0.7694
p.P104H	DO49987	CESC	ICGC	PASSS	DEG_SPOP_SBC_1	104:108	Mutation altering degron motif	0.7694
p.L112F	DO228215	LICA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.2222
p.L112F	DO228215	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	104:108	Mutation rewiring degron network	0.2222
p.Q124K	DO228974	LICA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.2778
p.T118N	DO229026	LICA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.8166
p.G129R	DO222662	MELA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1389
p.L196F	DO35654	PBCA	ICGC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation rewiring degron network	0.2778
p.S142R	DO232761	PBCA	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation blocking phosphorylation signal	0.5556
p.S422P	DO229453	SKCA	ICGC	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.1111
p.P117L	DO218874	SKCA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.7582
p.A125S	SIDM02039	Colorectal Carcinoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation blocking phosphorylation signal	0.6944
p.P191L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.6471
p.P191L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.6471
p.P191L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.6471
p.S194F	SIDM00545	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7982
p.S194F	ACH-000987	Skin Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7982
p.S194F	Mewo	skin	COSMIC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation altering degron motif	0.7982
p.Y107D	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PASSS	DEG_SPOP_SBC_1	104:108	Mutation altering degron motif	0.7325
p.K110E	SIDM00967	Ovarian Carcinoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation blocking ubiquitination signal	0.6111
p.K110E	SIDM00967	Ovarian Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	104:108	Mutation blocking ubiquitination signal	0.7222
p.Y117C	SIDM00535	Chondrosarcoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.5976
p.Y117C	SIDM00293	Small Cell Lung Carcinoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.5976
p.Y117C	SIDM00619	Thyroid Gland Carcinoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.5976
p.Y117C	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.5976
p.Y117C	SIDM00324	Neuroblastoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.5976
p.Y117C	SIDM00289	B-Lymphoblastic Leukemia	GDSC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.5976
p.K186N	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation blocking ubiquitination signal	0.6667
p.K186N	ACH-000823	Esophageal Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation blocking ubiquitination signal	0.6667
p.K186N	KYSE-140	oesophagus	COSMIC	PPSTS	DEG_SPOP_SBC_1	190:194	Mutation blocking ubiquitination signal	0.6667
p.I427T	SIDM01114	Non-Cancerous	GDSC	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.25
p.I427T	PWR-1E	prostate	COSMIC	VLSSS	DEG_SPOP_SBC_1	430:434	Mutation rewiring degron network	0.25
p.G129E	SIDM00516	Melanoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1389
p.G129E	ACH-002166	Skin Cancer	CCLE	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1389
p.G129E	MZ7-mel	skin	COSMIC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation rewiring degron network	0.1389
p.T118A	ACH-002309	Sarcoma	CCLE	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.825
p.T118A	SW684	soft tissue	COSMIC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation altering degron motif	0.825
p.Y110C	SW684	soft tissue	COSMIC	VYTPVAS	DEG_SCF_FBW7_1	116:122	Mutation blocking ubiquitination signal	0.6111
p.Y110C	SW684	soft tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	104:108	Mutation blocking ubiquitination signal	0.7222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAD18

UniProt ID: Q9NS91

Entrez ID: 56852

Protein name: E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAD18 in