DegronMD

Uniprot ID: Q9NS91

Source protein: E3 ubiquitin-protein ligase RAD18

Source gene: RAD18

Class: DEG_SCF_FBW7_1

Location: 116:122

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 79.9857

COIL: 0.7571

CONS_SCORE: 0.3325

DSS_SCORE: 0.311

HELIX: 0.1

FCONS_SCORE: 0.9878

RIG_SCORE: 0.7883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K110N	TCGA-AG-A002	READ	TCGA	VYTPVAS	DEG_SCF_FBW7_1	0.6111
p.K110N	TCGA-DK-A6AW	BLCA	TCGA	VYTPVAS	DEG_SCF_FBW7_1	0.6111
p.K110N	DO48566	BLCA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	0.6111
p.K110N	DO233718	GACA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	0.6111
p.V120L	TCGA-LN-A9FP	ESCA	TCGA	VYTPVAS	DEG_SCF_FBW7_1	0.5654
p.L112F	DO228215	LICA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	0.2222
p.Q124K	DO228974	LICA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	0.2778
p.T118N	DO229026	LICA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	0.8166
p.G129R	DO222662	MELA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	0.1389
p.P117L	DO218874	SKCA	ICGC	VYTPVAS	DEG_SCF_FBW7_1	0.7582
p.A125S	SIDM02039	Colorectal Carcinoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	0.6944
p.K110E	SIDM00967	Ovarian Carcinoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	0.6111
p.Y117C	SIDM00535	Chondrosarcoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	0.5976
p.Y117C	SIDM00293	Small Cell Lung Carcinoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	0.5976
p.Y117C	SIDM00619	Thyroid Gland Carcinoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	0.5976
p.Y117C	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	0.5976
p.Y117C	SIDM00324	Neuroblastoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	0.5976
p.Y117C	SIDM00289	B-Lymphoblastic Leukemia	GDSC	VYTPVAS	DEG_SCF_FBW7_1	0.5976
p.G129E	SIDM00516	Melanoma	GDSC	VYTPVAS	DEG_SCF_FBW7_1	0.1389
p.G129E	ACH-002166	Skin Cancer	CCLE	VYTPVAS	DEG_SCF_FBW7_1	0.1389
p.G129E	MZ7-mel	skin	COSMIC	VYTPVAS	DEG_SCF_FBW7_1	0.1389
p.T118A	ACH-002309	Sarcoma	CCLE	VYTPVAS	DEG_SCF_FBW7_1	0.825
p.T118A	SW684	soft_tissue	COSMIC	VYTPVAS	DEG_SCF_FBW7_1	0.825
p.Y110C	SW684	soft_tissue	COSMIC	VYTPVAS	DEG_SCF_FBW7_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SCF_FBW7_1	116:122	VYTPVAS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons