DegronMD

Uniprot ID: Q9NS91

Source protein: E3 ubiquitin-protein ligase RAD18

Source gene: RAD18

Class: DEG_APCC_KENBOX_2

Location: 150:154

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9324

ASA_SCORE: 100.14

COIL: 0.5312

CONS_SCORE: 0.3897

DSS_SCORE: 0.5348

HELIX: 0.2588

FCONS_SCORE: 1.0528

RIG_SCORE: 0.7289

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S144F	TCGA-55-A493	LUAD	TCGA	IKENK	DEG_APCC_KENBOX_2	0.6111
p.S144F	DO26328	LUAD	ICGC	IKENK	DEG_APCC_KENBOX_2	0.6111
p.S155R	TCGA-BS-A0UF	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.75
p.S155R	DO41488	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.75
p.E140K	TCGA-EO-A3B0	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.0556
p.E140K	DO219773	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.0556
p.S142R	DO232761	PBCA	ICGC	IKENK	DEG_APCC_KENBOX_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60476	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9671	More...
Q6IQ19	Centriole, cilia and spindle-associated protein	DEG_APCC_KENBOX_2	177:181	IKENK	APC,CDC20,FZR1	0.5499	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9324	More...
Q5RHP9	Glutamate-rich protein 3	DEG_APCC_KENBOX_2	445:449	IKENK	APC,CDC20,FZR1	0.8691	More...
Q5JVX7	Uncharacterized protein C1orf141	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9861	More...
Q5TEZ5	Uncharacterized protein C6orf163	DEG_APCC_KENBOX_2	321:325	IKENK	APC,CDC20,FZR1	0.8269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons