DegronMD

Uniprot ID: Q5RHP9

Source protein: Glutamate-rich protein 3

Source gene: ERICH3

Class: DEG_APCC_KENBOX_2

Location: 445:449

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8691

ASA_SCORE: 119.44

COIL: 0.7506

CONS_SCORE: 0.429

DSS_SCORE: 0.4044

HELIX: 0.2268

FCONS_SCORE: 0.9696

RIG_SCORE: 0.7517

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V438G	SIDM01314	Colorectal Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.1389
p.A458V	SIDM00845	Burkitt's Lymphoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.0833
p.A458V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	IKENK	DEG_APCC_KENBOX_2	0.0833
p.R442I	SIDM00193	Colorectal Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.25
p.R442I	SNU-81	large_intestine	COSMIC	IKENK	DEG_APCC_KENBOX_2	0.25
p.V452L	SIDM00292	Small Cell Lung Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.25
p.V452L	LU-165	lung	COSMIC	IKENK	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60476	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9671	More...
Q6IQ19	Centriole, cilia and spindle-associated protein	DEG_APCC_KENBOX_2	177:181	IKENK	APC,CDC20,FZR1	0.5499	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9324	More...
Q5RHP9	Glutamate-rich protein 3	DEG_APCC_KENBOX_2	445:449	IKENK	APC,CDC20,FZR1	0.8691	More...
Q5JVX7	Uncharacterized protein C1orf141	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9861	More...
Q5TEZ5	Uncharacterized protein C6orf163	DEG_APCC_KENBOX_2	321:325	IKENK	APC,CDC20,FZR1	0.8269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons