DegronMD

Uniprot ID: Q6IQ19

Source protein: Centriole, cilia and spindle-associated protein

Source gene: CCSAP

Class: DEG_APCC_KENBOX_2

Location: 177:181

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5499

ASA_SCORE: 109.32

COIL: 0.7506

CONS_SCORE: 0.557

DSS_SCORE: 0.5599

HELIX: 0.1916

FCONS_SCORE: 0.9174

RIG_SCORE: 0.6664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I177R	TCGA-AP-A1DV	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.6991
p.P183L	TCGA-DF-A2KU	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.2778
p.R172I	TCGA-EO-A22R	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.1944
p.R172I	DO42713	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1944
p.S174L	TCGA-GF-A6C9	SKCM	TCGA	IKENK	DEG_APCC_KENBOX_2	0.25
p.S174L	DO51254	SKCM	ICGC	IKENK	DEG_APCC_KENBOX_2	0.25
p.H182N	SIDM00301	Pancreatic Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.3056
p.H182N	ACH-000265	Pancreatic Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	0.3056
p.H182N	KP-4	pancreas	COSMIC	IKENK	DEG_APCC_KENBOX_2	0.3056
p.F184L	SIDM01451	Pancreatic Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.25
p.F184L	ACH-000933	Pancreatic Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60476	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9671	More...
Q6IQ19	Centriole, cilia and spindle-associated protein	DEG_APCC_KENBOX_2	177:181	IKENK	APC,CDC20,FZR1	0.5499	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9324	More...
Q5RHP9	Glutamate-rich protein 3	DEG_APCC_KENBOX_2	445:449	IKENK	APC,CDC20,FZR1	0.8691	More...
Q5JVX7	Uncharacterized protein C1orf141	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9861	More...
Q5TEZ5	Uncharacterized protein C6orf163	DEG_APCC_KENBOX_2	321:325	IKENK	APC,CDC20,FZR1	0.8269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons