DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IKENK
Uniprot ID:
O60476
Source protein:
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
Source gene:
MAN1A2
Class:
DEG_APCC_KENBOX_2
Location:
150:154
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9671
ASA_SCORE:
115.22
COIL:
0.8396
CONS_SCORE:
0.2283
DSS_SCORE:
0.5123
HELIX:
0.1314
FCONS_SCORE:
1.0116
RIG_SCORE:
0.719
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I161V
TCGA-33-6737
LUSC
TCGA
IKENK
DEG_APCC_KENBOX_2
0.1389
p.I161V
DO26866
LUSC
ICGC
IKENK
DEG_APCC_KENBOX_2
0.1389
p.P160R
TCGA-A5-A0G5
UCEC
TCGA
IKENK
DEG_APCC_KENBOX_2
0.1667
p.P160R
DO41416
UCEC
ICGC
IKENK
DEG_APCC_KENBOX_2
0.1667
p.K143N
TCGA-EE-A181
SKCM
TCGA
IKENK
DEG_APCC_KENBOX_2
0.25
p.K143N
DO37444
SKCM
ICGC
IKENK
DEG_APCC_KENBOX_2
0.25
p.K143N
SIDM01387
Small Cell Lung Carcinoma
GDSC
IKENK
DEG_APCC_KENBOX_2
0.25
p.K143N
ACH-000921
Lung Cancer
CCLE
IKENK
DEG_APCC_KENBOX_2
0.25
p.K151Q
TCGA-EO-A22X
UCEC
TCGA
IKENK
DEG_APCC_KENBOX_2
0.6944
p.K151Q
DO43907
UCEC
ICGC
IKENK
DEG_APCC_KENBOX_2
0.6944
p.E140D
TCGA-EO-A3AY
UCEC
TCGA
IKENK
DEG_APCC_KENBOX_2
0.0556
p.E140D
DO222762
COCA
ICGC
IKENK
DEG_APCC_KENBOX_2
0.0556
p.E140D
DO43202
UCEC
ICGC
IKENK
DEG_APCC_KENBOX_2
0.0556
p.E152K
TCGA-YC-A89H
BLCA
TCGA
IKENK
DEG_APCC_KENBOX_2
0.7022
p.E152K
DO51948
BLCA
ICGC
IKENK
DEG_APCC_KENBOX_2
0.7022
p.V145I
DO11854
GBM
ICGC
IKENK
DEG_APCC_KENBOX_2
0.1944
p.P158Q
DO229053
LICA
ICGC
IKENK
DEG_APCC_KENBOX_2
0.2222
p.E147G
DO35242
PACA
ICGC
IKENK
DEG_APCC_KENBOX_2
0.25
p.P160S
SIDM00007
Other Solid Cancers
GDSC
IKENK
DEG_APCC_KENBOX_2
0.1667
p.P160S
ACH-001550
Skin Cancer
CCLE
IKENK
DEG_APCC_KENBOX_2
0.1667
p.P160S
MCC13
skin
COSMIC
IKENK
DEG_APCC_KENBOX_2
0.1667
p.P155A
SIDM00539
Esophageal Carcinoma
GDSC
IKENK
DEG_APCC_KENBOX_2
0.3056
p.P155A
ACH-001496
Esophageal Cancer
CCLE
IKENK
DEG_APCC_KENBOX_2
0.3056
p.P155A
ESO26
oesophagus
COSMIC
IKENK
DEG_APCC_KENBOX_2
0.3056
Drug responses associated with MAN1A2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IKENK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60476
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
DEG_APCC_KENBOX_2
150:154
IKENK
APC,CDC20,FZR1
0.9671
More...
Q6IQ19
Centriole, cilia and spindle-associated protein
DEG_APCC_KENBOX_2
177:181
IKENK
APC,CDC20,FZR1
0.5499
More...
Q9NS91
E3 ubiquitin-protein ligase RAD18
DEG_APCC_KENBOX_2
150:154
IKENK
APC,CDC20,FZR1
0.9324
More...
Q5RHP9
Glutamate-rich protein 3
DEG_APCC_KENBOX_2
445:449
IKENK
APC,CDC20,FZR1
0.8691
More...
Q5JVX7
Uncharacterized protein C1orf141
DEG_APCC_KENBOX_2
150:154
IKENK
APC,CDC20,FZR1
0.9861
More...
Q5TEZ5
Uncharacterized protein C6orf163
DEG_APCC_KENBOX_2
321:325
IKENK
APC,CDC20,FZR1
0.8269
More...