DegronMD

Uniprot ID: O60476

Source protein: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

Source gene: MAN1A2

Class: DEG_APCC_KENBOX_2

Location: 150:154

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9671

ASA_SCORE: 115.22

COIL: 0.8396

CONS_SCORE: 0.2283

DSS_SCORE: 0.5123

HELIX: 0.1314

FCONS_SCORE: 1.0116

RIG_SCORE: 0.719

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E152K	TCGA-YC-A89H	BLCA	TCGA	IKENK	DEG_APCC_KENBOX_2	0.7022
p.E152K	DO51948	BLCA	ICGC	IKENK	DEG_APCC_KENBOX_2	0.7022
p.K151Q	TCGA-EO-A22X	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.6944
p.K151Q	DO43907	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.6944
p.P155A	SIDM00539	Esophageal Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.3056
p.P155A	ACH-001496	Esophageal Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	0.3056
p.P155A	ESO26	oesophagus	COSMIC	IKENK	DEG_APCC_KENBOX_2	0.3056
p.K143N	TCGA-EE-A181	SKCM	TCGA	IKENK	DEG_APCC_KENBOX_2	0.25
p.K143N	DO37444	SKCM	ICGC	IKENK	DEG_APCC_KENBOX_2	0.25
p.K143N	SIDM01387	Small Cell Lung Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.25
p.K143N	ACH-000921	Lung Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	0.25
p.E147G	DO35242	PACA	ICGC	IKENK	DEG_APCC_KENBOX_2	0.25
p.P158Q	DO229053	LICA	ICGC	IKENK	DEG_APCC_KENBOX_2	0.2222
p.V145I	DO11854	GBM	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1944
p.P160R	TCGA-A5-A0G5	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.1667
p.P160R	DO41416	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1667
p.P160S	SIDM00007	Other Solid Cancers	GDSC	IKENK	DEG_APCC_KENBOX_2	0.1667
p.P160S	ACH-001550	Skin Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	0.1667
p.P160S	MCC13	skin	COSMIC	IKENK	DEG_APCC_KENBOX_2	0.1667
p.I161V	TCGA-33-6737	LUSC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.1389
p.I161V	DO26866	LUSC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.1389
p.E140D	TCGA-EO-A3AY	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.0556
p.E140D	DO222762	COCA	ICGC	IKENK	DEG_APCC_KENBOX_2	0.0556
p.E140D	DO43202	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 24 of 24 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IQ19	Centriole, cilia and spindle-associated protein	DEG_APCC_KENBOX_2	177:181	IKENK	APC,CDC20,FZR1	0.5499	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9324	More...
Q5RHP9	Glutamate-rich protein 3	DEG_APCC_KENBOX_2	445:449	IKENK	APC,CDC20,FZR1	0.8691	More...
O60476	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9671	More...
Q5JVX7	Uncharacterized protein C1orf141	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9861	More...
Q5TEZ5	Uncharacterized protein C6orf163	DEG_APCC_KENBOX_2	321:325	IKENK	APC,CDC20,FZR1	0.8269	More...

Showing 1 to 6 of 6 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons