DegronMD

Uniprot ID: Q5TEZ5

Source protein: Uncharacterized protein C6orf163

Source gene: C6orf163

Class: DEG_APCC_KENBOX_2

Location: 321:325

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8269

ASA_SCORE: 128.24

COIL: 0.7298

CONS_SCORE: 0.2773

DSS_SCORE: 0.6694

HELIX: 0.2472

FCONS_SCORE: 0.7102

RIG_SCORE: 0.7828

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L319I	TCGA-EO-A3AY	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	0.2778
p.L319I	DO43202	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	0.2778
p.V320L	SIDM00640	Mesothelioma	GDSC	IKENK	DEG_APCC_KENBOX_2	0.3056
p.V320L	ACH-000335	Lung Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60476	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9671	More...
Q6IQ19	Centriole, cilia and spindle-associated protein	DEG_APCC_KENBOX_2	177:181	IKENK	APC,CDC20,FZR1	0.5499	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9324	More...
Q5RHP9	Glutamate-rich protein 3	DEG_APCC_KENBOX_2	445:449	IKENK	APC,CDC20,FZR1	0.8691	More...
Q5JVX7	Uncharacterized protein C1orf141	DEG_APCC_KENBOX_2	150:154	IKENK	APC,CDC20,FZR1	0.9861	More...
Q5TEZ5	Uncharacterized protein C6orf163	DEG_APCC_KENBOX_2	321:325	IKENK	APC,CDC20,FZR1	0.8269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons