DegronMD - O60476(MAN1A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I161V	TCGA-33-6737	LUSC	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1389
p.I161V	DO26866	LUSC	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1389
p.P160R	TCGA-A5-A0G5	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.P160R	DO41416	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.K143N	TCGA-EE-A181	SKCM	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation substituting flanking lysine	0.25
p.K143N	DO37444	SKCM	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation substituting flanking lysine	0.25
p.K143N	SIDM01387	Small Cell Lung Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation substituting flanking lysine	0.25
p.K143N	ACH-000921	Lung Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation substituting flanking lysine	0.25
p.K151Q	TCGA-EO-A22X	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation altering degron motif	0.6944
p.K151Q	DO43907	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation altering degron motif	0.6944
p.E140D	TCGA-EO-A3AY	UCEC	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.0556
p.E140D	DO222762	COCA	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.0556
p.E140D	DO43202	UCEC	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.0556
p.E152K	TCGA-YC-A89H	BLCA	TCGA	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation altering degron motif	0.7022
p.E152K	DO51948	BLCA	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation altering degron motif	0.7022
p.V145I	DO11854	GBM	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1944
p.P158Q	DO229053	LICA	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.2222
p.E147G	DO35242	PACA	ICGC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.25
p.P160S	SIDM00007	Other Solid Cancers	GDSC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.P160S	ACH-001550	Skin Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.P160S	MCC13	skin	COSMIC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.P155A	SIDM00539	Esophageal Carcinoma	GDSC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.3056
p.P155A	ACH-001496	Esophageal Cancer	CCLE	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.3056
p.P155A	ESO26	oesophagus	COSMIC	IKENK	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.3056

Kaplan plot for MAN1A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAN1A2

UniProt ID: O60476

Entrez ID: 10905

Protein name: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB (EC 3.2.1.113) (Mannosidase alpha class 1A member 2) (Processing alpha-1,2-mannosidase IB) (Alpha-1,2-mannosidase IB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAN1A2 in